Catalytic nucleophilic addition of terminal alkynes to α,β-unsaturated-γ-lactams

Photocatalyst-Free, Visible-Light-Mediated C(sp3)–H Arylation of Amides via a Solvent-Caged EDA Complex

“…An alternative, valuable approach is the functionalization of existing simple amides. New synthetic opportunities for the direct C­(sp 3 )–H functionalization of simple amides have emerged, such as (i) radical chemistry using transition metal catalysis − and (ii) transition-metal-free, nonradical pathways using Lewis or Brønsted acid or base catalyzed chemistry, the latter of which is an active research area of our group and others …”