Introduction::
In this investigation, we employed a continuous flow reactor to synthesize
nickel (Ni) nanoparticles exhibiting uniform size distribution and excellent stability. Our focus centered
on exploring the impact of reactant dilution and flow rate on the synthesis process.
Result::
It was observed that the optimization of these parameters played a pivotal role in obtaining
small-sized Ni nanoparticles. Specifically, we achieved successful synthesis using a solution of
0.00025 M NiCl2·6H2O and 0.002 M NaBH4, with a flow rate of 25 mL/h. The resulting Ni nanoparticles
were effectively coated with the CTAB surfactant, as confirmed through thorough analysis
using TEM and PSD techniques. Additionally, the interaction between the surfactant and nanoparticles
was verified via FTIR analysis. We subjected them to high-pressure alkene hydrogenation to
assess the catalytic activity of the synthesized Ni nanoparticles.
Method::
Encouragingly, the Ni nanoparticles exhibited excellent performance, producing hydrogenated
products with high yields. Moreover, we capitalized on Ni nanoparticles' catalytic effect for
synthesizing two natural compounds, brittonin A and dehydrobrittonin A. Remarkably, both compounds
were successfully isolated in quantifiable yields. This synthesis protocol boasted several advantages,
including low catalyst loading, omission of additives, broad substrate scope, straightforward
product separation, and the ability to recover the catalyst up to eight times. In summary, this
study effectively showcased the potential of continuous flow reactor technology in synthesizing stable
and uniformly distributed nanoparticles.
Conclusion::
Additionally, it highlighted the effectiveness of Ni nanoparticles as catalysts in various
chemical reactions. The findings from this study hold significant implications for developing more
efficient and sustainable chemical synthesis protocols.