Catalytic immunotherapy-photothermal therapy combination for melanoma by ferroptosis-activating vaccine based on artificial nanoenzyme

Fang, Tianxu; Ma, Siyu; Wei, Yi; Yang, Jiahong; Zhang, J.; Shen, Qi

doi:10.1016/j.mtchem.2022.101308

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…The types of nanocatalysts, reaction substrates, catalytic mechanisms and catalytic immunomodulation on antitumor immunity are listed in detail in Table 1. [471][472][473][474][475][476][477][478][479][480][481][482][483][484][485][486] Despite the tremendous progress of catalytic nanomedicines over recent years, their further development and clinical transformation still suffer from a number of challenges, which can be summarized as follows.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Wu,

Li,

Wen

et al. 2024

Chem. Soc. Rev.

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Section: Conclusion and Perspectivementioning

confidence: 99%

“…The types of nanocatalysts, reaction substrates, catalytic mechanisms and catalytic immunomodulation on antitumor immunity are listed in detail in Table 1. 471–486…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Wu,

Li,

Wen

et al. 2024

Chem. Soc. Rev.

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“…Iron can enter the cell through different routes depending on its source (Ma S. et al, 2023). In the ferric form (Fe3+), iron from dietary sources is converted to ferrous iron (Fe2+) by the action of duodenal cytochrome B (DyctB) and then transported into the cell via the divalent metal transporter 1 (DMT1) (Ma X. et al, 2023;Crescenzi et al, 2023).…”

Section: Iron Metabolism Accumulation and Regulationmentioning

confidence: 99%

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Adzavon,

Zhao,

et al. 2024

Front. Pharmacol.

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Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. Ferroptosis is currently proposed as one of the most promising means of combating tumor resistance. Nevertheless, the problem of ferroptosis resistance in certain cancer cells has been identified. This review first, investigates the mechanisms of ferroptosis induction in cancer cells. Next, the problem of cancer cell resistance to ferroptosis, as well as the underlying mechanisms is discussed. Recently discovered ferroptosis-suppressing biomarkers have been described. The various types of nanoparticles that can induce ferroptosis are also discussed. Given the ability of nanoparticles to combine multiple agents, this review proposes nanoparticle-based ferroptosis cell death as a viable method of circumventing this resistance. This review suggests combining ferroptosis with other forms of cell death, such as apoptosis, cuproptosis and autophagy. It also suggests combining ferroptosis with immunotherapy.

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“…Under laser irradiation, there was a significant increase in temperature and production of ROS. In addition, B16-OVA cells produced an abundance of ATP and HMGB-1, which effectively stimulated the immune system and enhanced the anti-tumor treatment [ 153 ]. CuTe NPs anti-tumor therapy research in PTT/PDT has received less attention and requires further development and investigation.…”

Section: Application Of Different Kinds Of Cu-based Nms In Ptt/pdtmentioning

confidence: 99%

Recent Progress of Copper-Based Nanomaterials in Tumor-Targeted Photothermal Therapy/Photodynamic Therapy

Zhuo,

Liu,

Aishajiang

et al. 2023

Pharmaceutics

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Nanotechnology, an emerging and promising therapeutic tool, may improve the effectiveness of phototherapy (PT) in antitumor therapy because of the development of nanomaterials (NMs) with light-absorbing properties. The tumor-targeted PTs, such as photothermal therapy (PTT) and photodynamic therapy (PDT), transform light energy into heat and produce reactive oxygen species (ROS) that accumulate at the tumor site. The increase in ROS levels induces oxidative stress (OS) during carcinogenesis and disease development. Because of the localized surface plasmon resonance (LSPR) feature of copper (Cu), a vital trace element in the human body, Cu-based NMs can exhibit good near-infrared (NIR) absorption and excellent photothermal properties. In the tumor microenvironment (TME), Cu2+ combines with H2O2 to produce O2 that is reduced to Cu1+ by glutathione (GSH), causing a Fenton-like reaction that reduces tumor hypoxia and simultaneously generates ROS to eliminate tumor cells in conjunction with PTT/PDT. Compared with other therapeutic modalities, PTT/PDT can precisely target tumor location to kill tumor cells. Moreover, multiple treatment modalities can be combined with PTT/PDT to treat a tumor using Cu-based NMs. Herein, we reviewed and briefly summarized the mechanisms of actions of tumor-targeted PTT/PDT and the role of Cu, generated from Cu-based NMs, in PTs. Furthermore, we described the Cu-based NMs used in PTT/PDT applications.

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Catalytic immunotherapy-photothermal therapy combination for melanoma by ferroptosis-activating vaccine based on artificial nanoenzyme

Cited by 5 publications

References 36 publications

Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Recent Progress of Copper-Based Nanomaterials in Tumor-Targeted Photothermal Therapy/Photodynamic Therapy

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