Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines

Catalytic asymmetric alkylation of ketones using organometallic reagents

“…These discoveries have permitted the development of an array of methods for the addition of organozinc reagents to aromatic ketones, enones and ketoesters [12,13,32]. Nevertheless, diorganozinc reagents have an inherent drawback crucial to practical applications [33,34].…”

Ruthenium-Catalyzed Transfer Hydrogenation for C–C Bond Formation: Hydrohydroxyalkylation and Hydroaminoalkylation via Reactant Redox Pairs

“…49 In this way, alkynes serve as chiral allylmetal equivalents. [50][51][52][53][54][55][56][57] A third mechanism for the coupling of primary alcohols with alkynes becomes operative when these conditions are applied to the propargyl ether, MeC≡CCH 2 OTIPS (TIPS = triisopropylsilyl) (Scheme 8). 58 Unlike closely related ruthenium catalyzed alkyne-alcohol C-C couplings, deuterium labeling studies corroborate a novel 1,2-hydride shift mechanism that converts metal-bound alkynes to vinyl carbenes that protonate to form siloxy-π-allylruthenium nucleophiles in the absence of intervening allenes.…”

<strong>New approach for the synthesis of pinane derived bisphosphines</strong>

“…Many research programs are carried out to develop new chiral reagents, ligands and catalysts. Currently, catalytic reactions have become one of the most important areas of organic chemistry, therefore the search for new chiral catalysts is now widely explored and developed [1]. One of the directions of research is the use of chiral natural compounds as substrates because they are readily available, cheap, and in many cases enantiomerically pure compounds.…”