Catalytic CH Bond Activation Reactions

Oxidative Coupling – Bonding between Two Nucleophiles

“…However, this bond formation mode does not meet the requirement of modern sustainable chemistry [11], since the organometallic reagents need to be derived from the corresponding hydrocarbons. In the following several years, replacing the organometallic reagents with various C-H or X-H nucleophiles to achieve greener oxidative couplings such as R 1 -H/R 2 -M 2 and R 1 -H/R 2 -H dominated the research area, in which numerous outstanding works have been reported [12][13][14][15]. Especially, transition-metal-catalyzed oxidative R 1 -H/R 2 -H coupling with air or O 2 as the oxidant is no doubt an ideal approach for bond formations [16,17].…”

Iodine-Mediated α-Acetoxylation of 2,3-Disubstituted Indoles

“…However, these methods often involve unavoidable problems such as a relatively narrow scope of substrates, harsh reaction conditions, and the use of hazardous reagents. Recently, useful C–H functionalization reactions that can provide a shortcut to complex molecules from easily available materials have attracted much interest, and development of practical methods for C–H functionalization of side chains of indoles is also among these important subjects …”