A first
approach toward understanding the targeted design of molecular
photoacoustic contrast agents (MPACs) is presented. Optical and photoacoustic
Z-scan spectroscopy was used to identify how nonlinear (excited-state)
absorption contributes to enhancing the photoacoustic emission of
the curcuminBF2 and bis-styryl (MeOPh)2BODIPY dyes relative to Cy3.
Spectroscopic and in cellulo studies are here reported on the very first BODIPY-luminol chemiluminescent resonance energy-transfer (CRET) cassette where the luminol CL agent is covalently linked to the BODIPY energy-transfer acceptor in a molecular dyad. The efficiency of intramolecular CRET investigated for the BODIPY-luminol dyad was found to be 64% resulting in a dual emissive response. Successful in cellulo biochemiluminescence via CRET was achieved in PMA activated splenocytes.
With the aim of developing potential antifungals, a series of chalcones incorporating sulfur either as part of a heteroaromatic ring (thiophene) or as a side chain (thiomethyl group) were synthesized and tested for their in vitro activity. Some of the compounds showed appreciable activity against a fluconazole-resistant strain, and could act as new hits for the design of better analogs.
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