Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents

Abstract

and obtained her degree in Pharmacology in 1999. She has received her Ph.D. degree in Chemistry from the A. N. Nesmeyanov Institute of Organoelement Compounds, Moscow, Russia, with Professor Yuri N. Belokon'. She had a predoctoral stay at the Institute of Organic Chemistry, Polish Academy of Sciences with Dr. C. Grela. After receiving her Ph.D. in 2003, she joined the group of Professor Ben L. Feringa at the University of Groningen as a postdoc. Her work was focused on enantioselective catalysis, mechanistic studies, and total synthesis, in particular using asymmetric conjugate addition. In 2007 she obtained the position of research scientist at Tibotec BVBA, a division of Johnson & Johnson in Belgium. Tim den Hartog was born in 1982, and he studied at the University of Amsterdam, The Netherlands, to obtain his degree in Organic Chemistry in 2005. He is currently performing his graduate studies in the Feringa Group at the University of Groningen in the field of asymmetric catalysis. His research focuses primarily on asymmetric conjugate addition. Koen Geurts was born in 1975, and he studied at the University of Groningen, The Netherlands, and obtained his degree in Organic Chemistry in 2002. He is currently finishing his graduate studies in the Feringa Group at the University of Groningen in the field of asymmetric catalysis. His thesis focuses primarily on asymmetric allylic alkylation. He has recently accepted a position as a chemical development engineer within SABIC Europe.

Phosphoramidite: privilegierte Liganden in der asymmetrischen Katalyse

“…[31,32] Frühere Entwicklungen der asymmetrischen konjugierten Addition in Gegenwart von Phosphoramiditen sind Gegenstand mehrerer Übersichten, [26,[110][111][112][113][114][115][116][120][121][122][123][124] daher liegt der Schwerpunkt der folgenden Abschnitte auf den Fortschritten, die seit 2002 auf diesem Gebiet erzielt wurden.…”

Catalytic asymmetric alkylation of ketones using organometallic reagents

“…4a) [41]. The results demonstrated that the longstanding paradigm of Cu(I) based catalysts favoring 1,4-selectivity over 1,2-selectivity in the addition of organometallic reagents, known since 1941, is not fully justified [3,[42][43][44]. It was shown that the a-substituent and the presence of a double bond in the substrate play a crucial role in obtaining high regio-and enantioselectivity and that highest enantioselectivities are obtained with branched, so bulky, Grignard reagents.…”

Combination of NH2OH·HCl and NaIO4: a new and mild reagent for the synthesis of vicinal diiodo carbonyl compounds

“…Organic haloalkanes are extensively used for carbon-heteroatom bond forming reactions 1 as well as the carbon-metal atom bond formation such as Grignard's reagent, [2][3][4][5] carbenoids [6][7] etc. Specifically, carbenoids are preferentially prepared from iodoalkanes since they are more reactive than other haloalkanes.…”