Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils

Liu, Yanru; Li, Pengwei; Suo, Jian-jun; Sun, Yan; Zhang, Boai; Lü, Hong; Zhu, Hua; Zhang, Guobin

doi:10.1111/jphp.12261

Cited by 31 publications

(18 citation statements)

References 24 publications

(24 reference statements)

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“…Catalpol, a major bioactive compound enriched by the dried root of R. glutinosa with the chemical structure previously shown [30], has been found to demonstrate broad and diverse bioactivities including neuroprotection, ameliorating cognition deficits and diabetic encephalopathy, potentially attenuating inflammation-related neurodegenerative diseases, protection against cerebral and cardiac ischemia/reperfusion injury, hepatoprotection, and radioprotection [31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Wang

Yang

Zhang

et al. 2015

Physiology & Behavior

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Section: Introductionmentioning

confidence: 99%

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Wang

Yang

Zhang

et al. 2015

Physiology & Behavior

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“…It has been reported that catalpol, an iridous glycoside, has neuroprotective [13] and cerebroprotective effects [18][19][20]. Catalpol attenuated LPS-induced microglial activation and the expression of ROS, iNOS, NO, and TNF-α [21][22][23]. Catalpol inhibited ischemia-induced apoptosis by modulating Bcl-2 and BAX, increasing the activities of SOD and GSH-Px, and inhibiting the activation of caspase-3 [24][25][26].…”

mentioning

confidence: 99%

Amelioration by Catalpol of Atherosclerotic Lesions in Hypercholesterolemic Rabbits

Liu

Zhang

2015

Planta Med

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The aim of the present study was to evaluate the effects of catalpol administration on atherosclerosis. Atherogenesis was induced by a high-cholesterol chow in male New Zealand White rabbits that were randomly assigned to receive atorvastatin (5 mg/kg/day), catalpol (5 mg/kg/day), or vehicle by oral gavage for 12 weeks. The rabbits were sacrificed after 12 weeks, and the thoracic aorta and serum were collected for further pathological and molecular biological analysis. Catalpol administration resulted in significantly attenuated atherosclerotic lesions. Total cholesterol, triglycerides, and low-density lipoprotein cholesterol were remarkably reduced, and high-density lipid cholesterol was elevated in the catalpol-treated group. Catalpol reduced the levels of tumor necrosis factor-α, interleukin-6, monocyte chemoattractant protein-1, soluble vascular cell adhesion molecule-1, and soluble intercellular adhesion molecule-1 in the serum, as well as vascular cell adhesion molecule-1, monocyte chemoattractant protein-1, tumor necrosis factor-α protein, inducible nitric oxide synthase, matrix metalloproteinases-9, and nuclear factor-κB protein65 in the aortic arch. In addition, catalpol treatment reduced the lipid peroxidation levels, while elevating antioxidant capacity. Catolpol pretreatment inhibited the nuclear translocation and DNA binding activity of nuclear factor-κB protein in oxygenized low-density lipoprotein-stimulated EA.hy926 cells. Furthermore, catolpol pretreatment activated nuclear factor erythroid 2-related factor 2 and upregulated the expression of its downstream antioxidant enzyme heme oxygenase. In summary, catalpol attenuated atherosclerotic lesions by the inhibition of inflammatory cytokines and oxidative stress status in a rabbit atherosclerotic model and enhanced the antioxidant capacity in oxygenized low-density lipoprotein-stimulated EA.hy926 cells. These results suggest that catalpol may be used to prevent and attenuate atherosclerosis.

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“…This iridoid is the main bioactive compound in the dried root of Rehmannia glutinosa, and has been found to have broad and diverse pharmacological activities that include neuroprotection, alleviation of cognitive deficits and diabetic encephalopathy (Jiang et al, 2015). Catalpol potentially attenuates inflammation-related neurodegenerative diseases and offers protection against cerebral and cardiac ischemia/reperfusion injury, as well as hepatoprotection and radioprotection Fu et al, 2014;Huang et al, 2013;Liu et al, 2014;Wang et al, 2010;Zhang et al, 2013Zhang et al, , 2007. In addition, Dong and Chen, (Dong and Chen, 2013), reported that catalpol reduces the kidney weight index, improves kidney function and pathological change, reducing the tissue level of angiotensin II, TGF-1, connective tissue growth factor, fibronectin, and collagen type IV.…”

Section: Iridoid Glycosidesmentioning

confidence: 99%

Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

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Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and antiinflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds.

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Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils

Abstract: These data suggested that the efficacy of catalpol pretreatment on CI/R injury may be attributed to reduction of free radicals and inhibition of lipid peroxidation and ET-1 production.

Cited by 31 publications

References 24 publications

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Amelioration by Catalpol of Atherosclerotic Lesions in Hypercholesterolemic Rabbits

Monoterpenes modulating cytokines - A review

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