Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)

Oliveira, Luciana de; Cunha, Alexandra Olímpio Siqueira; Mortari, Márcia Renata; Coimbra, Norberto Cysne; Santos, Wagner Ferreira dos

doi:10.1016/j.pnpbp.2005.10.016

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…The most widely used model to study the EPSE is the triggering of catalepsy [18]. 7 has the lowest ED 50 from the azecine derivatives; it is still below the value of the effective dose for the inhibition of CAR (▶table 3).…”

Section: Catalepsymentioning

confidence: 99%

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Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics

et al. 2017

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Dibenzo- and benzindolo-azecines represent a class of potential neuroleptics. To characterize the effectiveness at the dopamine and 5-HT-receptor representative structures were synthesized and tested by radio ligand binding studies, in vivo and in vitro studies.Neuroleptic potency and the risk of side effects of the prodrug 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl isobutyrate, an ester derivative of the most promising azecine 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol (LE404), was tested in vivo concerning conditioned avoidance response inhibition, locomotor activity and triggering of catalepsy vs. haloperidol as a reference. Also ester hydrolysis was examined using porcine liver esterase to thereby obtain an indication of the stability of the prodrug in vivo. An HPLC method was developed for purity control and determination of octanol/water-distribution coefficients.It has been shown that the tested substances in their efficacy are comparable to haloperidol and risperidone, but the therapeutic index in most cases is larger. Esterification as a prodrug principle leads to significantly prolonged effectiveness.

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Section: Catalepsymentioning

confidence: 99%

“…After 240 min throughout the test (jumps [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], no significant (p ≤ 0.05) difference was visible between reaction times of the con-trol group and the treatment group. After 60 and 150 min, all reaction times of jumps 6-15 are significantly different from the control value.…”

Section: Durations Of Action Ofmentioning

confidence: 99%

Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics

et al. 2017

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“…The neurobiological activity of the venom of A. vicina, was investigated. Oliveira and colleagues [125] showed that the central injection of the non-enzymatic fraction of the venom induced catalepsy in Wistar compared to the neuroleptic drug haloperidol, a nonselective D2 dopamine antagonist. This effect was reversed by the injection of theophylline or ketamine.…”

Section: Actions On Mood Disordersmentioning

confidence: 99%

New Perspectives in Drug Discovery Using Neuroactive Molecules From the Venom of Arthropods

Mortari¹,

Cunha²

2013

An Integrated View of the Molecular Recognition and Toxinology - From Analytical Procedures to Biomedical Applications

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“…Besides, these peptides are assumed to trigger histamine release via G-protein coupled receptor cascades; additionally, regarding the venom proteome, mastoparans are thought to regulate some venom enzymes (12,60,61). It is known that some mastoparans bind to G-protein coupled receptors (GPCRs) that are involved in the activation of different types of basophils, chemotaxis of leukocytes, and neurotoxicity (62,63). Several mastoparan and protonectin homologues have been sequenced from different wasp species using Edman degradation and tandem mass spectrometry (MS/MS) (6,59).…”

Section: Peptidesmentioning

confidence: 99%

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Santos

Pieroni

Menegasso

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis.

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Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from 2000 to the present about the new scenario of Hymenoptera venom composition. On account of new technologies in the proteomic approach, which presents high resolution and sensitivity, the combination of developments in new instruments, fragmentation methods, strategic analysis, and mass spectrometry have become indispensable tools for interrogation of protein expression, molecule interaction, and post-translational modifications. Thus, the biochemical characterization of Hymenoptera venom has become a major subject of research in the area of allergy and immunology, in which proteomics has been an excellent alternative to assist the development of more specific extracts for diagnosis and treatment of hypersensitive patients to Hymenoptera venoms.

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Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)

Cited by 10 publications

References 30 publications

Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics

Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics

New Perspectives in Drug Discovery Using Neuroactive Molecules From the Venom of Arthropods

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