Untitled

Abstract

Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from 2000 to the present about the new scenario of Hymenoptera venom composition. On account of new technologies in the proteomic approach, which presents high resolution and sensitivity, the combination of developments in new instruments, fragmentation methods, strategic analysis, and mass spectrometry have become indispensable tools for interrogation of protein expression, molecule interaction, and post-translational modifications. Thus, the biochemical characterization of Hymenoptera venom has become a major subject of research in the area of allergy and immunology, in which proteomics has been an excellent alternative to assist the development of more specific extracts for diagnosis and treatment of hypersensitive patients to Hymenoptera venoms.

Natural products in neuroprotective therapies: Experimental and cheminformatics approaches to manage neurological disorders

“…Recent research has further explored the potential of natural products in treating NDs. Bee and wasp venoms have been found to contain cocktails of peptides and proteins, enzymes, biogenic amines, and nitrogencontaining compounds that have been used successfully for centuries to treat inflammatory diseases, including NDs [109] . The neuroprotective effects of bee venom have been investigated in treating conditions such as PD and multiple sclerosis (MS), with results showing the potential to prevent the loss of dopaminergic neurons, reduce neuroinflammation, and inhibit apoptosis [110][111][112] .…”