Cat scratch disease causing encephalitis

Fan, Jerry; Ali, Hameed

doi:10.1080/08998280.2020.1756141

Cited by 7 publications

(8 citation statements)

References 10 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the clear advantage of augmentation with Minocycline in psychosis, this may in a similar way act on the CNS inflammation by improving microglia function; but also, it may be that the effect of Minocycline is related to antibiotic effects on an as yet unidentified bacteria that plays a role in the development or the persistence of schizophrenia-like psychotic symptoms. Although epidemiological associations between schizophrenia and exposure to infectious agents including Toxoplasmosis and cat scratch disease have been found, a causal link has remained elusive ( Endres et al, 2020 , 2022 ; Fan and Ali, 2020 ; Fuglewicz et al, 2017 ). There may also be effects on translocation of bacteria across the gut wall, thus influencing the brain-gut axis ( Nemani et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Fitton

Sweetman

Heseltine-Carp

2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Fitton

Sweetman

Heseltine-Carp

2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

“…Bartonella spp. can also induce encephalitis and microvascular injury, or could precipitate an autoimmune process, any of which could contribute to pathogenesis of neuropsychiatric symptoms (Scheidegger et al 2011, Fan and Ali 2020, Tsukamoto et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Schizophrenia and Bartonella spp. Infection: A Pilot Case–Control Study

Lashnits

Maggi

Jarskog

et al. 2021

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

Recently, infections with emerging zoonotic bacteria of the genus Bartonella have been reported in association with a range of central nervous system (CNS) symptoms. Currently, it remains unknown if Bartonella spp. infection is associated with symptoms of schizophrenia/schizoaffective disorder (SCZ/SAD). The objective of this study was to determine if there is an association between Bartonella species infection and SCZ/SAD. A secondary objective was to determine if SCZ/SAD symptoms were more severe among participants with documented Bartonella spp. infection. Using a case-control study design, 17 cases and 13 controls were evaluated with a series of clinical and cognitive assessments. Blood samples were collected and tested for Bartonella spp. infection using serological, microbiological, and molecular techniques. People with SCZ/SAD were more likely than healthy volunteers to have Bartonella spp. DNA in their bloodstream, with 11 of 17 cases (65%) positive by Bartonella spp. droplet digital PCR (ddPCR). In comparison, only one healthy volunteer was Bartonella spp. ddPCR positive (8%, p = 0.0024). Based on serology, Bartonella spp. exposure was common among people with SCZ/SAD (12 of 17) as well as among healthy volunteers (12 of 13), with no significant difference between the groups ( p = 0.196). Within the case group of people with SCZ/SAD, there was no significant difference in SCZ/SAD severity scores between people with and without ddPCR evidence of Bartonella spp. infection. This pilot study provides preliminary evidence in support of future investigations that should examine a potential contribution of Bartonella spp. infection to SCZ/SAD.

show abstract

“…Cat scratch encephalopathy most commonly presents with seizures. Other CNS manifestations of B. henselae include encephalitis, aseptic meningitis, status epilepticus, transverse myelitis, and radiculitis 43,44 . It can also present with dementia in HIV patients 45 .…”

Section: Final Diagnosis: Brain Abscess Due To B Henselaementioning

confidence: 99%

“…Other CNS manifestations of B. henselae include encephalitis, aseptic meningitis, status epilepticus, transverse myelitis, and radiculitis. 43,44 It can also present with dementia in HIV patients. 45 Although a case of brain granulomatous process involving the right thalamus and surrounding tissues associated with B. henselae infection has been reported in the literature, 44 to our knowledge, multiple brain abscesses have not been reported before.…”

Section: Final Diagnosis: Brain Abscess Due To B Henselaementioning

confidence: 99%

Into the unknown: Diagnosing mysterious brain lesions

Kassab

Isada

Azar

et al. 2022

Transplant Infectious Dis

View full text Add to dashboard Cite

In this inaugural clinicopathological conference, the invited experts discussed the diagnostic approach to central nervous system infections in immunocompromised hosts.The case presented involved a pancreas-kidney transplant recipient with multiple brain abscesses caused by Bartonella henselae. CSF metagenomic next-generation sequencing played a significant role in the diagnosis. Bartonella henselae is a gramnegative zoonotic pathogen that causes cat-scratch disease, which can be transmitted to humans through cat bites or scratches. Symptoms can vary in severity, correlating with the patient's immune status. Visceral organ involvement, ocular involvement, and neurological manifestations have been reported in immunocompromised patients, but brain abscesses are rare.

show abstract

Cat scratch disease causing encephalitis

Cited by 7 publications

References 10 publications

Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Schizophrenia and Bartonella spp. Infection: A Pilot Case–Control Study

Into the unknown: Diagnosing mysterious brain lesions

Contact Info

Product

Resources

About