Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Fitton, Rebecca; Sweetman, Jennifer; Heseltine-Carp, William

doi:10.1016/j.bbih.2022.100518

Cited by 24 publications

(16 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors believe that females may be at higher risk at persistent low‐grade inflammation compared to males. There have been previous findings of systemic low‐grade inflammation in psychiatric disorders in the literature, 9 which has various implications for treatment and clinical outcomes 10,11 . Furthermore, we have also corroborated the evidence from previous work 5 that female patients are significantly more likely to report neuropsychiatric symptoms in the post‐COVID‐19 period, as in this study anxiety and myalgia were significantly more common in females.…”

Section: Discussionsupporting

confidence: 90%

Examining the relationship between inflammatory biomarkers during COVID‐19 hospitalization and subsequent long‐COVID symptoms: A longitudinal and retrospective study

Sykes,

Van der Feltz‐Cornelis,

Holdsworth

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

IntroductionLong‐COVID is a heterogeneous condition with a litany of physical and neuropsychiatric presentations and its pathophysiology remains unclear. Little is known about the association between inflammatory biomarkers, such as interleukin‐6 (IL‐6) and C‐reactive protein (CRP) in the acute phase, and persistent symptoms after hospitalization in COVID‐19 patients.MethodsIL‐6, CRP, troponin‐T, and ferritin were analyzed at admission for all patients with COVID‐19 between September 1, 2020 to January 10, 2021. Survivors were followed up 3‐months following hospital discharge and were asked to report persistent symptoms they experienced. Admission data were retrospectively collected. Independent t‐tests and Mann–Whitney U tests were performed.ResultsIn a sample of 144 patients (62.5% male, mean Age 62 years [SD = 13.6]) followed up 3 months after hospital discharge, the commonest symptoms reported were fatigue (54.2%), breathlessness (52.8%), and sleep disturbance (37.5%). In this sample, admission levels of IL‐6, CRP and ferritin were elevated. However, those reporting myalgia, low mood, and anxiety at follow‐up had lower admission levels of IL‐6 (34.9 vs. 52.0 pg/mL, p = .043), CRP (83 vs. 105 mg/L, p = .048), and ferritin (357 vs. 568 ug/L, p = .01) respectively, compared with those who did not report these symptoms. Multivariate regression analysis showed that these associations were confounded by gender, as female patients had significantly lower levels of IL‐6 and ferritin on admission (29.5 vs. 56.1, p = .03 and 421.5 vs. 589, p = .001, respectively) and were more likely to report myalgia, low mood and anxiety, when compared to males.ConclusionsOur data demonstrate that female patients present more often with lower levels of inflammatory biomarkers on admission which are subsequently associated with long‐term post‐COVID symptoms, such as myalgia and anxiety, in those discharged from hospital with severe COVID‐19. Further research is needed into the role of serum biomarkers in post‐COVID prognostication.

show abstract

Section: Discussionsupporting

confidence: 90%

Examining the relationship between inflammatory biomarkers during COVID‐19 hospitalization and subsequent long‐COVID symptoms: A longitudinal and retrospective study

Sykes,

Van der Feltz‐Cornelis,

Holdsworth

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…As immune-inflammation response is an essential component of multifactorial disease pathogenesis ( 3 ), alterations in immune-inflammation response across the course of these two major psychiatric disorders have become critical. This is further supported by the accumulating evidence for the differential effects of anti-inflammatory medications on the treatment of mental disorders ( 4 ). Thus, the present Research Topic aims to examine the aspects of the immune-inflammation response conditions altered in the patients of SCZ and BD.…”

mentioning

confidence: 70%

Editorial: The inflammation markers in schizophrenia and bipolar disorder: Do we have promising results?

2023

View full text Add to dashboard Cite

show abstract

“…(20)(21)(22)(23) And this has implications for treatment and treatment outcomes in a variety of mental disorders . (24,25) Persistent neuropsychiatric symptoms are commonly reported in those with Long-COVID. Meta-analysis data show the commonest symptoms to be sleep disturbance, anxiety, objective cognitive impairments, and fatigue.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Biomarkers as Predictors of Mortality and Persistent Symptoms at Follow-up in Patients with Severe COVID-19

Sykes

Feltz-Cornelis

Holdsworth

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Serum inflammatory biomarkers such as C-reactive protein (CRP) are an established tool for predicting mortality in COVID-19 patients. Data have also suggested that such biomarkers are persistently elevated in patients with Long-COVID. In this study we aimed to assess the relationship between a panel of serum biomarkers (CRP, IL-6, troponin-T, and ferritin), inpatient mortality, and persistent symptoms post-discharge in COVID-19 survivors. Methods Data were collected retrospectively for all patients with COVID-19 admitted between 1st September 2020 and 10th January 2021. Admission CRP, IL-6, ferritin, and troponin-T were collected alongside routinely collected clinical data. A standardised dataset was collected for survivors when they attended clinical follow-up with the local post-hospitalisation COVID-19 follow-up service. Results A total of 626 patients (mean age 70.1 [SD=15.8], 55% male) had all biomarkers recorded. The overall mortality rate in this cohort was 28.4%. Higher levels of IL-6 (p<0.001) and troponin-T (p<0.001) were associated with a significantly higher risk of inpatient mortality. A total of 144 patients received 3-month follow-up, the commonest reported symptoms were fatigue (54.2%), breathlessness (52.8%), and sleep disturbance (37.5%). Patients who reported myalgia, low mood, and anxiety were found to have lower median levels of IL-6, CRP, and ferritin, respectively. Conclusions Raised levels of IL-6 and TT on admission are associated with a significantly increased risk of inpatient mortality in those hospitalised with COVID-19, however, raised inflammatory markers at the time of hospital admission show no association with residual symptom burden at 3-month follow-up in surviving patients.

show abstract

Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Cited by 24 publications

References 101 publications

Examining the relationship between inflammatory biomarkers during COVID‐19 hospitalization and subsequent long‐COVID symptoms: A longitudinal and retrospective study

Examining the relationship between inflammatory biomarkers during COVID‐19 hospitalization and subsequent long‐COVID symptoms: A longitudinal and retrospective study

Editorial: The inflammation markers in schizophrenia and bipolar disorder: Do we have promising results?

Inflammatory Biomarkers as Predictors of Mortality and Persistent Symptoms at Follow-up in Patients with Severe COVID-19

Contact Info

Product

Resources

About