Cat-Scratch Disease and Bone Scintigraphy

Ismaili-Alaoui, Nadia; Vuong, V.; Marcu-Marin, M.; Sergent-Alaoui, A.; Chevallier, Bertrand; Labriolle-Vaylet, Claire de

doi:10.1097/rlu.0b013e31824d252f

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…Of the three organisms infecting this patient, B. henselae alone, or in combination with the two other intravascular bacteria may have contributed to the headaches, neurocognitive abnormalities and seizures reported in this patient. The osteolytic bone lesions documented in this patient just prior to initiation of antibiotics are also consistent with lesions that have been increasingly described in immunocompromised HIV-infected patients and in children with cat scratch disease [37,38]. Despite the use of different combinations of anticonvulsant and antidepressant medications, effective control of the headaches and seizures was never achieved until treatment with doxycycline was instituted.…”

Section: Resultssupporting

confidence: 79%

Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian

et al. 2013

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BackgroundDuring a two year period, a 27-year-old female veterinarian experienced migraine headaches, seizures, including status epilepticus, and other neurological and neurocognitive abnormalities. Prior to and during her illness, she had been actively involved in hospital-based work treating domestic animals, primarily cats and dogs, in Grenada and Ireland and anatomical research requiring the dissection of wild animals (including lions, giraffe, rabbits, mongoose, and other animals), mostly in South Africa. The woman reported contact with fleas, ticks, lice, biting flies, mosquitoes, spiders and mites and had also been scratched or bitten by dogs, cats, birds, horses, reptiles, rabbits and rodents. Prior diagnostic testing resulted in findings that were inconclusive or within normal reference ranges and no etiological diagnosis had been obtained to explain the patient’s symptoms.MethodsPCR assays targeting Anaplasma spp. Bartonella spp. and hemotopic Mycoplasma spp. were used to test patient blood samples. PCR positive amplicons were sequenced directly and compared to GenBank sequences. In addition, Bartonella alpha Proteobacteria growth medium (BAPGM) enrichment blood culture was used to facilitate bacterial growth and Bartonella spp. serology was performed by indirect fluorescent antibody testing.ResultsAnaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum DNA was amplified and sequenced from the woman’s blood, serum or blood culture samples. Her serum was variably seroreactive to several Bartonella sp. antigens. Despite symptomatic improvement, six months of doxycycline most likely failed to eliminate the B. henselae infection, whereas A. platys and Candidatus M. haematoparvum DNA was no longer amplified from post-treatment samples.ConclusionsAs is typical of many veterinary professionals, this individual had frequent exposure to arthropod vectors and near daily contact with persistently bacteremic reservoir hosts, including cats, the primary reservoir host for B. henselae, and dogs, the presumed primary reservoir host for A. platys and Candidatus Mycoplasma haematoparvum. Physicians caring for veterinarians should be aware of the occupational zoonotic risks associated with the daily activities of these animal health professionals.

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Section: Resultssupporting

confidence: 79%

Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian

et al. 2013

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“…According to the present case report, combination of both serologic tests with histopathologic examination with or without Polymerase chain reaction test (PCR) in the tissue specimen must to be considered for the Cat-scratch disease diagnosis in adult patients presenting prolonged-fever, weight loss and multiple adenopathies, as the presence of these symptoms has been previously described in this pathology [10, 11, 16-19]. The bone involvement of Bartonella henselae is rare and revealed the possibility of a systemic form of the disease, which could mimic a splenic lymphoma [11, 18, 20, 21]. …”

Section: Discussionmentioning

confidence: 99%

Cat-Scratch Disease In Adult Hospitalized For Prolonged-Fever Associated With Multiple Lymphadenopathies and Weight Loss

Guiyedi¹,

Haddad²,

Okome-Nkoumou³

et al. 2013

TOMICROJ

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We report a 19-year-old patient with a Cat-scratch disease presenting three months continuous alteration of the general condition, including prolonged-fever, anorexia, asthenia, weight loss associated with adenitis and multiple thoracic-abdominal adenopathies, leukocytosis with neutrophil polynuclear predominance, and increased of C-reactive protein. The serologies of toxoplasmosis, infectious mononucleosis, human immunodeficiency virus, Brucellosis, Bartonellosis and the tuberculosis research by tuberculin reaction test and Ziehl acid-alcohol resistant bacilli direct examination were negatives. The cytomegalovirus and Epstein-Barr virus serologies were positives only for immunoglobulin-G. The Bartonella henselae diagnosis was made with the analysis of histopathological specimens. The clinical and biological symptoms regressed following eight weeks of azithromycin's treatment.According to this observation, the cat-scratch disease should be considered in differential diagnosis of patients presenting prolonged-fever associated with multiple lymphadenopathies and weight loss. The azithromycin would be an alternative therapeutic issue for this pathology in case of confirmed efficacy by studies in a large patient population.

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“…On the other hand, atypical symptoms, observed in 5%–9% of cases, may involve Parinaud’s oculoglandular syndrome, encephalitis, endocarditis, haemolytic anaemia, hepatosplenomegaly, glomerulonephritis, pneumonia, recurrent bacteraemia and osteomyelitis 5. Instances of CSD presenting with cough6 and tonsillitis7 have also been documented. Furthermore, diverse rash types are reported, with maculopapular rashes like those in the current case occurring in 5%–13% of patients 8…”

Section: Descriptionmentioning

confidence: 99%

Atypical presentation of severe cat scratch disease: suspected from patient history and physical findings

Takeda,

Kobayashi,

Kubotsu

et al. 2024

BMJ Case Rep

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Cat-Scratch Disease and Bone Scintigraphy

Cited by 7 publications

References 10 publications

Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian

Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian

Cat-Scratch Disease In Adult Hospitalized For Prolonged-Fever Associated With Multiple Lymphadenopathies and Weight Loss

Atypical presentation of severe cat scratch disease: suspected from patient history and physical findings

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