Castleman's Disease with Myasthenia Gravis

Lee, Sang-Kwon; Kim, Do-Hyung; Son, Bong Soo

doi:10.5090/kjtcs.2012.45.3.199

Cited by 10 publications

(19 citation statements)

References 6 publications

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“…Although we identified several reports of patients with Castleman's disease complicated by lung damage ( 14 - 16 ), each of the cases involved abnormalities of the lung parenchyma, indicating that the mechanism was different from that of our patient. Cases of Castleman's disease complicated by myasthenia gravis have been reported ( 7 , 17 , 18 ); however, the fact that our patient was negative for anti-AChR antibodies as well as other symptoms was inconsistent with myasthenia gravis. We confirmed a peripheral nerve disorder in our patient, which could have been involved in the type II respiratory failure.…”

Section: Discussioncontrasting

confidence: 66%

Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure

et al. 2017

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A 66-year-old man with a several year history of thrombocytopenia, pleural effusion and ascites, anasarca, and organomegaly presented with general fatigue, appetite loss, dyspnea with type II respiratory failure. The precise history of the patient and the re-evaluation of lymph node and bone marrow biopsies conducted by the previous physician indicated TAFRO syndrome. The patient's laboratory data improved for a year with tocilizumab, but then worsened to the point that the patient required artificial ventilation due to the deterioration of type II respiratory failure. The replacement of tocilizumab with rituximab yielded a steady improvement, but it was necessary to address the patient's persistent respiratory failure. Peripheral nerve disorder might have been involved with the patient's respiratory failure.

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Section: Discussioncontrasting

confidence: 66%

Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure

et al. 2017

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“…Less than 10 previous cases of CD associated with MG have been reported in the world literature with no evidence of hyperplasia or malignancy of the thymus in any of the cases. Only three of the cases have reported that the mass located in the retroperitoneum [ 3 , 5 , 13 ] and myasthenic crisis occurred in two [ 3 , 13 ] out of the three, which means our case is the third one to date.…”

Section: Discussionmentioning

confidence: 95%

A case report of retroperitoneal pararenal Castleman’s disease associated with myasthenia gravis

et al. 2014

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BackgroundCastleman’s disease (CD) is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue. The combination of an occurrence of retroperitoneal pararenal CD with myasthenia gravis (MG) is extremely rare.Case presentationThe patient was admitted to our hospital for investigation of a retroperitoneal pararenal tumor which had been coincidentally diagnosed at a local hospital where he was admitted because of MG. The patient subsequently underwent an exploratory laparotomy and suffered from postoperative myasthenic crisis. Pathological examination revealed a left retroperitoneal mass of CD (hyaline vascular type). There was no recurrence of disease found after 7 months.ConclusionsCD with MG is a rare condition. Postoperative myasthenic crisis is a severe complication. The possibility of its occurrence must be in physicians’ minds and the risk of postoperative myasthenic crisis must be carefully considered when evaluating MG patients undergoing surgery.

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“…It was suggested that the MuSK may function via an alternative pathway linked to myasthenic syndrome that is different from the pathway of the acetylcholine receptor antibody. 7) Seven previous cases of Castleman's disease associated with myasthenia gravis, along with myasthenic crisis, which is one of the most serious postoperative complications of Castleman's disease, have been reported in the literature ( Table 1), [8][9][10][11][12][13][14] In one study, 11 (5.4%) of a total of 204 patients with surgically treated thymic epithelial tumors experienced postoperative myasthenic crisis. 15) Of the eight patients described in the literature with Castleman's disease and myasthenia gravis (including the present patient), three patients (37.5%) experienced postoperative myasthenic crisis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Castleman's Disease with Myasthenia Gravis

Ishikawa

Kato

Aragaki

et al. 2014

ATCS

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A rare case of Castleman's disease with myasthenia gravis is reported. A 55-year-old woman with bilateral ptosis, speech impairment, and severe dyspnea had been previously diagnosed with myasthenia gravis. Computed tomography showed a 5 cm × 3 cm paratracheal mass in the mediastinum, thought to be an ectopic thymoma. Two days after surgical resection, the patient suddenly developed dyspnea. Postoperative myasthenic crisis was diagnosed, and plasmapheresis was performed. Her general condition improved, and her subsequent course was uneventful. The final pathological diagnosis was mediastinal solitary Castleman's disease, hyaline vascular type. Castleman's disease with myasthenia gravis is especially rare. One of the serious complications is postoperative myasthenic crisis. For patients with myasthenia gravis, the rate of postoperative myasthenic crisis seems significantly higher in Castleman's disease patients than in patients with thymic epithelial tumors. Castleman's disease with myasthenia gravis is discussed along with a review of the literature.

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Castleman's Disease with Myasthenia Gravis

Cited by 10 publications

References 6 publications

Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure

Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure

A case report of retroperitoneal pararenal Castleman’s disease associated with myasthenia gravis

A Case of Castleman's Disease with Myasthenia Gravis

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