A case report of retroperitoneal pararenal Castleman’s disease associated with myasthenia gravis

Abstract

BackgroundCastleman’s disease (CD) is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue. The combination of an occurrence of retroperitoneal pararenal CD with myasthenia gravis (MG) is extremely rare.Case presentationThe patient was admitted to our hospital for investigation of a retroperitoneal pararenal tumor which had been coincidentally diagnosed at a local hospital where he was admitted because of MG. The patient subsequently underwent an exploratory laparotomy and suffered from postoperative myasthenic crisis. Pathological examination revealed a left retroperitoneal mass of CD (hyaline vascular type). There was no recurrence of disease found after 7 months.ConclusionsCD with MG is a rare condition. Postoperative myasthenic crisis is a severe complication. The possibility of its occurrence must be in physicians’ minds and the risk of postoperative myasthenic crisis must be carefully considered when evaluating MG patients undergoing surgery.

An Autopsy Case of TAFRO Syndrome with Type II Respiratory Failure

“…He was discharged on day 442, since his general condition (other than respiratory status) was satisfactory. While previous studies reported that respiratory failure was related to myasthenia gravis in some cases of Castleman’s disease [ 6 , 7 ], anti-acetylcholine receptor antibodies were negative in our patient. A previous nerve conduction study of our patient [ 5 ] revealed axonal involvement and demyelination changes, leading us to suspect peripheral nerve disorder.…”

Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure

“…However, the type II respiratory failure persisted. Although some patients with Castleman's disease have been reported to be complicated by myasthenia gravis with respiratory failure ( 7 , 8 ), the patient was negative for anti-acetylcholine receptor antibodies. A nerve conduction study showed axonal involvement demyelination changes ( Table 2 ), and peripheral nerve involvement was suspected.…”

Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review

“…only one such case of MCD (Table 1). [3][4][5][6][7][8][9][10][11][12][13][14] Of the 12 UCD cases, 10 (83%) involve the hyaline vascular subtype of UCD, while the other 2 involve the mixed-cell variety. Eight cases (67%) presented with symptoms of MG, three (25%) presented with erosive skin and mucosal lesions of pemphigus before MG symptoms developed, and one (8%) presented as an acute abdomen.…”

“…Myasthenia gravis (MG) has been reported in 11 previous cases of UCD and one case of MCD, while optic disc edema initially described as pseudotumour cerebri (PTC) has been noted in five cases of MCD. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] To our knowledge, there have been no cases published that involve all three of these disorders. We describe the case of a young female patient who developed PTC and MG in the context of UCD, and provide a review of the literature involving the intersection of these disorders.…”