Castleman's disease of the lung: radiographic, high-resolution CT, and pathologic findings.

Barrie, James R.; English, John; Müller, Néstor L.

doi:10.2214/ajr.166.5.8615241

Cited by 33 publications

(27 citation statements)

References 6 publications

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“…To our knowledge, isolated parenchymal pulmonary involvement is very rare in CD; a handful of cases have previously been reported. Usually, the disease manifests as a solitary pulmonary nodule [2,6,7,8,9,10,11]. Intrafissural development, as observed in our patient, is an original observation; review of published literature revealed a unique similar case report [12].…”

Section: Discussionmentioning

confidence: 64%

Castleman's Disease: An Intrapulmonary Form with Intrafissural Development

Racil

Rouhou

Ismail

et al. 2009

The Scientific World JOURNAL

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Castleman's disease (CD) is an uncommon, mainly benign, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is exceedingly rare. We describe a case of CD in a 23-year-old woman with a 4-year history of recurring dyspnea and nonproductive cough, whose chest X-ray showed an abnormal shadow of the right hilum. Chest computed tomography confirmed the presence of a tissue-density mass of the right lower lobe, demonstrating poor contrast enhancement, associated with multiple laterotracheal and mediastinal lymphadenopathies. The patient underwent curative surgery, revealing a right hilar compressive mass, with an intrafissural development between the superior and middle lobes. Pneumonectomy was performed due to profuse bleeding. This case of CD is particular because of its unusual intrapulmonary location and its intrafissural development. Poor contrast enhancement is atypical in CD.

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Section: Discussionmentioning

confidence: 64%

Castleman's Disease: An Intrapulmonary Form with Intrafissural Development

Racil

Rouhou

Ismail

et al. 2009

The Scientific World JOURNAL

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“…Interleukin-6 (IL-6) is implicated in CD pathogenesis, inducing B-cell proliferation, hypergammaglobulinanemia, and acute phase responses 1 . Mediastinal lymphadenopathy is common but other pulmonary manifestations are infrequent 2,3 . Multiple treatments have been reported 1 ; unsurprisingly an evolving role of biological therapies is emerging.…”

Section: Title: Castleman Disease and Lymphocytic Interstitial Pneumomentioning

confidence: 99%

Castleman disease and lymphocytic interstitial pneumonia: a complex diagnostic and management challenge

2016

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“…Although the disease is commonly localized, MCD has been recognized (7). MCD occasionally manifests interstitial pulmonary involvement (8,9)…”

Section: Case Reportmentioning

confidence: 99%

“…These lesions are pathologically characterized by dense lymphoplasmacytic infiltration (8,9 (6). Death in MCD is either caused by sepsis, systemic inflammation leading to multi-organ system failure, or the development of malignancy (6).…”

Section: Dmentioning

confidence: 99%