A Case of IgG4-related Lung Disease Associated with Multicentric Castleman's Disease and Lung Cancer

Ikari, Jun; Kojima, Masaru; Tomita, Kazuhiro; Nakamura, Tõru; Toyoda, Futoru; Otsuki, Yoshiro; Shimizu, Satoru; Kobayashi, Hiroshi; Nakamura, Hidenori

doi:10.2169/internalmedicine.49.3176

Cited by 18 publications

(8 citation statements)

References 18 publications

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“…Usually, causes of mortality of MCD include respiratory failure , renal failure, complication of infections, and progression to malignant lymphoma [11] . Previous reports have stated that IgG4-RD may develop as a complication of MCD in some cases, whereas both diseases may develop at the same time in some cases; therefore, discriminating one from the other has not been always easy [13] , [14] , [15] . The clinical picture of multicentric Castleman's disease (MCD) is characterized by various observations, such as fever due to excessive IL-6 production, high C-reactive protein (CRP) level, low albumin (Alb) level, and anemia; therefore, the effects of steroid monotherapy in patients with MCD are limited.…”

Section: Discussionmentioning

confidence: 99%

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Mikumo

Hamada

Harada

et al. 2017

Respiratory Medicine Case Reports

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A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S6 biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.

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Section: Discussionmentioning

confidence: 99%

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Mikumo

Hamada

Harada

et al. 2017

Respiratory Medicine Case Reports

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“…A limited number of studies on the serum IL-6 levels in IgG4-RD have been published (23)(24)(25)(26). Yamamoto et al reported that 5 of 27 patients (19%) with systemic IgG4-RD presented with elevated serum levels of IL-6, however, the clinical features of such patients were unclear (23).…”

Section: Discussionmentioning

confidence: 99%

IgG4-related Disease Involving Multiple Organs with Elevated Serum Interleukin-6 Levels

et al. 2016

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A 63-year-old woman presented to our hospital with elevated levels of serum IgG4, marked wall thickening of the gallbladder, hepatomegaly, and abdominal lymphadenopathy. She experienced a recurrent fever and leg edema. Her laboratory data demonstrated anemia, hypoalbuminemia, and elevated serum levels of interleukin-6 and C-reactive protein. The patient was eventually diagnosed with IgG4-related disease according to the comprehensive diagnostic criteria, although the patient exhibited common clinical manifestations of multicentric Castleman disease such as a fever, anemia, lymphadenopathy, and elevated levels of serum interleukin-6 and C-reactive protein. This case report highlights the difficulties in differentiating between these two diseases.

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“…Anecdotal coincidences of CD with lymphomas, B-cell non-Hodgkin, and Hodgkin lymphomas and with multiple myeloma were reported [18, 19]. A few reports described co-existence of CD (frequently unicentric and HV type) and solid neoplasms including ovarian, colorectal, bladder, renal, lung and tongue cancer, hepatocellular carcinoma, and retroperitoneal leiomyosarcoma, diagnosed in both early or advanced stages of disease [17, 20–25]. …”

Section: Discussionmentioning

confidence: 99%

Castleman’s disease mimicking lymph node metastases in a young woman with laryngeal cancer

Serkies¹,

Łazar-Poniatowska²,

Seredyńska³

et al. 2016

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Laryngeal cancer occurs rarely in adolescents and young people. Castleman’s disease is a rare lymphoproliferative disorder of uncertain etiopathogenesis and heterogeneous clinicopathological forms. Involved lymph nodes and extranodal lesions in the course of Castleman’s disease may mimic malignant involvement. We report a case of an 18-year-old woman with T2N0M0 laryngeal glottis cancer treated with definitive radiotherapy. During the irradiation, the patient underwent an excision of incidentally discovered left-sided enlarged cervical lymph nodes located outside the irradiated area. Coincidental hyaline vascular type of Castleman’s disease was diagnosed. During six-year follow-up she has been free of cancer relapse and Castleman’s disease symptoms.

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A Case of IgG4-related Lung Disease Associated with Multicentric Castleman's Disease and Lung Cancer

Abstract: Abstract

Cited by 18 publications

References 18 publications

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

IgG4-related Disease Involving Multiple Organs with Elevated Serum Interleukin-6 Levels

Castleman’s disease mimicking lymph node metastases in a young woman with laryngeal cancer

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