A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Mikumo, Hironori; Hamada, Naoki; Harada, Eiji; Yanagihara, Toyoshi; Ogata, Saiko; Yabuuchi, Hidetake; Ijichi, Kayo; Takayama, K.; Nakanishi, Yoichi

doi:10.1016/j.rmcr.2017.03.023

Cited by 2 publications

(2 citation statements)

References 11 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Excessive expression of RANKL was also reported in lymphoma [12], adult T cell leukemia [13], and chronic lymphocytic leukemia [14]. In IgG4RD, there are a number of reports which described an elevation of serum IL-6 [15][16][17]. However, an abnormality of serum Ca concentration was not reported.…”

Section: Discussionmentioning

confidence: 99%

A case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure

et al. 2018

View full text Add to dashboard Cite

A 40-year-old male was hospitalized with renal impairment and severe hypercalcemia. His concentration of serum IgG4 was high, but serum whole PTH, 1-25(OH) vitamin D3 and PTHrP were not elevated. Computed tomography showed swelling of the bilateral lacrimal glands and systemic lymphadenopathy. The histological findings of lacrimal gland biopsy fulfilled the diagnostic criteria of IgG4-related ophthalmic disease (IgG4ROD). Bone scintigraphy showed increased ectopic uptake in the stomach, heart, lungs, and kidneys. He died on day 16 of admission, although the therapies for hypercalcemia were continued. Autopsy results showed an increase of osteoclasts in the bone marrow and metastatic calcification in multiple organs, and excluded from the differential diagnosis other disorders which present lymph-node swelling and hypercalcemia such as cancer, lymphoma, Castleman's disease, and sarcoidosis. He was given a diagnosis of IgG4ROD with osteolytic hypercalcemia.

show abstract

Section: Discussionmentioning

confidence: 99%

A case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A patient who conforms to all above four criteria can be diagnosed as IgG4-RD, those who conform to three of above four criteria can be diagnosed as IgG4-RD probable, and any who conform to the above two of above four criteria can be diagnosed as IgG4-RD suspicious[ 4 , 12 , 13 ]. In the same year at the “IgG4-RD” international conference held in the United States, researchers reached a consensus that the diagnosis of IgG4-RD should primarily rely on pathological features rather than IgG-positive plasma cell count and ratio, although they are an essential condition of diagnosis[ 14 ]. In this case, the patient at least fulfills two of above criteria: (1) one or more organs experience diffuse/focal swelling; and (2) serum IgG4 > 135 mg /dL, and therefore was diagnosis as diagnosed as IgG4-RD suspicious.…”

Section: Discussionmentioning

confidence: 99%

Highlighting the importance of early diagnosis in progressive multi-organ involvement of IgG4-related disease: A case report and review of literature

Xue

Wang

et al. 2018

WJCC

View full text Add to dashboard Cite

IgG4-related disease (IgG4-RD) is an increasingly recognized pathological entity that tends to involve multiple organs with an elevated level of serum IgG4, which is easily misdiagnosed owing to sharing common clinical features with a variety of other diseases. Here, we report an interesting IgG4-RD case of a woman with progressive multi-organ involvement for over 19 years, started with swollen eyelids, dry eye and mouth, and polydipsia and hydruria. Imaging diagnosis revealed diffuse enlargement of the parotid glands, enlargement of the head of the pancreas, pulmonary infection and interstitial lung. Serological tests showed a remarkable elevation of the serum IgG4, and cytological analysis further revealed a large amount of lymphoplasmacytic infiltration into the focal lobule, and IgG4-positive cell infiltration in bladder mucosa. Therapeutically, the patient responded well to steroid therapy, and thus, she was diagnosed as IgG4-RD suspicious. This report highlights the importance of an early diagnosis in this autoimmune disease and suggests that patients with a clinically unclear cause of inflammation, swelling and refractory glands, rhinitis, pancreatitis, hypophysitis, and/or interstitial pneumonia should be considered for IgG4-RD. The plasma IgG4 level and lymphoplasmacytic infiltration may be useful indexes for screening, and a low dose of steroid maintaining therapy may offer benefits for patients with IgG4-RD.

show abstract

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Cited by 2 publications

References 11 publications

A case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure

A case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure

Highlighting the importance of early diagnosis in progressive multi-organ involvement of IgG4-related disease: A case report and review of literature

Contact Info

Product

Resources

About