Castleman’s disease of the head and neck

Song, Jae Jun; Jung, Myung Ho; Woo, Jeong Soo; Chae, Sung Won; Hwang, Soon Jae; Lee, Heung Man

doi:10.1007/s00405-005-0963-9

Cited by 24 publications

(19 citation statements)

References 14 publications

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“…In this report, we have reviewed the literature regarding patients with parotid gland involvement in CD and analyzed the clinical characteristics of their cases (Table 1). 3,4,7,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] In our review,…”

Section: Discussionmentioning

confidence: 99%

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Castleman Disease of the Parotid Gland: A Case Report

Liu¹,

Wang²,

Wei-Xian³

2020

Journal of Oral and Maxillofacial Surgery

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Castleman disease is a rare lymphoproliferative disorder characterized by the formation of painless hyperplastic lymph nodes. It can affect any lymph nodes of the body but rarely affects the salivary gland. We describe a patient with unicentric Castleman disease presenting as a parotid tumor and discuss the diagnosis and treatment of Castleman disease. A 39-year-old man had a painless lump on the right side of his face for 1 year. A computed tomography scan showed a well-defined, homogeneous mass in the right parotid gland. The patient underwent a right-sided superficial parotidectomy with preservation of the facial nerve. Histopathologic analysis of the excisional biopsy specimen confirmed the diagnosis of Castleman disease. No further treatment was administered, and the patient recovered well; no recurrence was present at the 1-year follow-up. Castleman disease is a lymphoproliferative disease that rarely affects the parotid gland. Histopathologic examination is regarded as the gold standard for diagnosis of Castleman disease. The current treatment for patients with unicentric Castleman disease is surgical resection. For patients with multicentric Castleman disease, more complex therapies are required.

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Section: Discussionmentioning

confidence: 99%

“…32 After complete resection of the mass, the prognosis of UCD is always good and patients experience no recurrence. 24,27 However, failure to completely remove the lesion results in a significant increase in the mortality rate from UCD. 33 There are many options for treatment of MCD but no official guidelines thus far.…”

Section: E3mentioning

confidence: 99%

Castleman Disease of the Parotid Gland: A Case Report

Liu¹,

Wang²,

Wei-Xian³

2020

Journal of Oral and Maxillofacial Surgery

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“…The histopathologic evaluation is the only way to make a final diagnosis. Surgical resection is the primary treatment for the hyaline vascular type of CD in the head and neck and is curative in virtually all cases, 4, 5 The plasma cell type is frequently associated with systemic manifestations and is often refractory to systemic therapy with corticosteroid and chemotherapy, particularly in the multicentric form. At present, there is no consensus as to the optimal management strategy for MCD.…”

Section: Discussionmentioning

confidence: 99%

Castleman's Disease of the Neck: Report of 4 Cases With Unusual Presentations

Jiang

Zhao

Liu

et al. 2011

Journal of Oral and Maxillofacial Surgery

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Purpose-Most of the previously reported cases of Castleman's disease (CD) in the neck were of the hyaline vascular type and the most common sign was an asymptomatic neck mass. To achieve a more general recognition of CD in the neck, we present four cases of CD in the neck with unusual presentations.Patients and Methods-We describe four cases of CD in the neck with unusual clinical manifestations, different histopathologic subtypes and discuss the problems arising in their clinical findings.Results-Two cases were plasma cell type with multiple bilateral enlarged lymph nodes and systemic manifestations. Two cases presented as a solitary mass were hyaline vascular type. One case underwent twice local recurrence and evolved from the hyaline vascular CD to follicular dendritic cell sarcoma.Conclusions-Cervical plasma cell CD may have a tendency to present as multiple masses on the both sides with systemic manifestations. It is necessary to pay more attention on the overgrowth of follicular dendritic cells in the hyaline vascular CD, which might represent a precursor of follicular dendritic cell sarcoma. KeywordsCastleman's disease; Neck; POEMS syndrome; Follicular dendritic cell sarcoma; Clinical manifestation In 1956, Castleman and colleagues first described the clinicopathologic entity of mediastinal lymphnoid hyperplasia with hyalinization of follicles and interfollicular vascular formation. 1 Subsequent reports described additional sites of disease and different names were used for this entity, including Castleman's disease (CD), angiofollicular or giant lymph node hyperplasia. 2 CD represents a morphologically distinct form of lymph node hyperplasia rather than a neoplasm or hamartoma. The etiology and pathogenesis of CD are not Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. There is a tight concentric layering of lymphocytes at the periphery of the follicles (corresponding to the mantle zone), resulting in an onion-skin appearance. The second major morphologic category of CD is known as the plasma cell type. It is characterized by a diffuse plasma cell proliferation in the interfollicular tissue. The hyaline vascular changes in the follicles are inconspicuous or absent. CD is clinically heterogeneous with either solitary CD (SCD) or multicentric CD (MCD). Over 90% of the cases are of the hyaline vascular type, and the remainder are of the plasma cell type. 3 The former usually presents with asymptomatic solitary mass and can mostly be treated effectively with surgery, 4-6 whereas the plasma cell type often has a more aggressive course and tends to be MCD with sy...

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“…Usually, preoperative work-up such as fine-needle aspiration [12][13][14] or core-needle biopsies [7] are not helpful to diagnose CD, except for occasional case reports [15]. Even, a surgical specimen could be misdiagnosed as lymphoma in trans-operatory frozen section [16].…”

Section: Discussionmentioning

confidence: 99%

“…Even, a surgical specimen could be misdiagnosed as lymphoma in trans-operatory frozen section [16]. Consequently, only definitive histopathology study is the way for a correct diagnosis [14,17]. According to the available literature, pelvic CD is rare and only achieve 2% of all cases [5,18,19].…”

Section: Discussionmentioning

confidence: 99%

A Diagnostic Challenge: Pelvic Castleman’s Disease

Ortiz-Mendoza¹

2013

Int. J. Gynecol. Obst. Res.

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Background: A rare lymph node hyperplasia that resembles malignant tumors is unicentric Castleman's disease. Although, it may appear in any lymph-node basin, the pelvis is an uncommon site for this disease, leading to a challenging preoperative diagnosis. Case Report: A pelvic tumor was discovered during the infertility sort out of a 31-year-old female. Computed tomography scans showed a pelvic mass with prominent vascular-supply, centrally calcified compressing the urinary bladder. With a malignant pelvic neoplasm diagnosis, a laparotomy was scheduled. At surgery, an 11-cm tumor infiltrating right mayor rectus-abdominis muscle, ipsilateral fallopian tube, and a urinary bladder segment was resected en-bloc. The final histopathology diagnosis was a hyaline-vascular, unicentric Castleman´s disease. After seven years of follow-up, the patient is disease-free. Conclusion: Unicentric pelvic Castleman's disease resembles malignant tumors and surgery is mandatory for its treatment and diagnosis.

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Castleman’s disease of the head and neck

Cited by 24 publications

References 14 publications

Castleman Disease of the Parotid Gland: A Case Report

Castleman Disease of the Parotid Gland: A Case Report

Castleman's Disease of the Neck: Report of 4 Cases With Unusual Presentations

A Diagnostic Challenge: Pelvic Castleman’s Disease

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