Cassia occidentalis: effect on healing skin wounds induced by Bothrops moojeni in mice

Abstract

Objective:To evaluate the healing activity of an extract from the leaves of Cassia occidentalis on skin wounds induced by the venom of Bothrops moojeni in mice. Methods:A total of 24 Swiss albino mice were divided into 4 groups: Group 1 animals were treated for 7 days with lanette cream; Group 2 animals were treated for 7 days with 10% leaf extract of Cassia occidentalis in lanette cream; Group 3 animals were treated for 14 days with lanette cream; and Group 4 animals were treated for 14 days with 10% leaf extract of Cassia occidentalis in lanette cream. To induce wounds, the animals were anesthetised intramuscularly after the dorsum cervical region was shaved and inoculated intradermally with 4 μg Bothrops moojeni venom. The gross and histological evaluations were assessed 7 and 14 days after inoculation of the poison. Results:Extract from the leaves of Cassia occidentalis decreased inflammation and epidermal hyperplasia and increased the vascular proliferation and reepithelialisation of wounds induced by Bothrops moojeni venom. Conclusions:These data suggest that the leaves of Cassia occidentalis stimulated the healing of wounds induced by the dermal venom of Bothrops moojeni in mice, and they can be considered an alternative product to treat wounds caused by this snakebites.

Myeloprotective activity of crude methanolic leaf extract of Cassia occidentalis in cyclophosphamide-induced bone marrow suppression in Wistar rats

“…[6] Leaf extracts of C. occidentalis can reduce the inflammatory effects of Bothrops snake ( Bothrops moojeni ) poison and accelerate the healing process. [7]…”

Phytoconstituent Isolation and Cytotoxicity Evaluation of the Egyptian Cassia occidentalis L. Possessing Selective Activity against Lung Carcinoma

“…Complete assignment of the 1 H-and 13 C-NMR signals was confrmed from their 1 H-1 H COSY, HSQC, and HMBC (Figures S37-S39) spectra analysis. Te spectral data and their comparison with similar compounds in the literature [29][30][31] could assign compound 9 as (E)-3-[4- (1-(benzol) [d] [1,3] dioxol-6-yl)-1, 3dihydroxy propan-2) phenyl] propanoic acid, which can loosely be called occidentalignan I (9). Tis represents a new compound and the frst report of its isolation from C. occidentalis [32].…”

“…C. occidentalis L. leaves have been used topically as a paste for the treatment of wounds, cutaneous diseases, sores, bone fractures, ringworms, fever, and throat infections, while their extracts have also been shown to pharmacologically possess antibacterial, antimalarial, antimutagenic [8][9][10], immunosuppressive [11], anticarcinogenic, and hepatoprotective activities [10,12,13]. Other uses, such as anti-infammatory, antidermatophyte, antibacterial, antiplasmodial, antifertility, antimalarial, and antidiabetic activities, as well as its capacity to repair, protect, and normalize liver functions have been reported [10,14].…”

GC-MS profile and antimicrobial activities of extracts from root of Senna occidentalis Linn.

“…The crude extracts of the various plant parts of S. occidentalis: leaves, seeds and pods have manifested antifungal activity against Candida albicans, Aspergillus clavatus and A. niger [9][10][11]. Chrysophanol which was isolated from methanol extract of S. occidentalis and its anthraquinone derivative upon application promoted wound healing activity in excision, incision, and dead space models in rats [12].…”