Cassia artemisiodes attenuates nociceptive and diabetes-induced neuropathic pain modalities apropos antioxidant and anti-inflammatory mechanisms

Ullah, Rahim; Badshah, Waseem; Ali, Gowhar; Ullah, Aman; Khan, Saleem Ullah; Ahmad, Nisar; Shahid, Muhammad; Naveed, Muhammad; Ullah, Sami; Bangash, Sudhair Abbas; Althobaiti, Yusuf S.

doi:10.1016/j.biopha.2022.112834

Cited by 11 publications

(3 citation statements)

References 51 publications

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“…These outcomes were consistent with the outcomes reported by [ 51 ], showing that the administration of plant extract reduces neuropathic pain in the CCl rat model. These findings are similar to those explained by [ 52 ] using plant extract Cassia artimisiodes for diabetes-induced neuropathic pain.…”

Section: Resultssupporting

confidence: 92%

“…These outcomes were consistent with the outcomes reported b [51], showing that the administration of plant extract reduces neuropathic pain in the CC rat model. These findings are similar to those explained by [52] using plant extract Cass artimisiodes for diabetes-induced neuropathic pain. The rats' groups of CCI developed significant hypersensitivity to mechano-stimuli (pin prick response) and dynamic stimuli (cotton bud and paint brush response) (Figure 10).…”

Section: Effect Of Different Pregabalin and Withania Coagulans Combin...supporting

confidence: 90%

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Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

Asghar

Aamir

Sheikh³

et al. 2022

Molecules

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The current study reports the fabrication of co-combination gel using Pregabalin and Withania coagulans fruit extract to validate its effectiveness for neuropathic pain in chronic constriction injury (CCI) rat models. Three topical gels were prepared using Carbopol 934 through a pseudo-ternary phase diagram incorporating the Pregabalin (2.5%), Withania coagulans extract (2%), and co-combination of both Pregabalin (2.5%) and Withania coagulans extract (2%). Gels were characterized. FTIR showed a successful polymeric network of the gel without any interaction. The drug distribution at the molecular level was confirmed by XRD. The AFM images topographically indicated the rough surface of gels with a size range from 0.25 to 330 nm. DSC showed the disappearance of sharp peaks of the drug and extract, showing successful incorporation into the polymeric network of gels. The in vitro drug release of co-combination gel was 73% over 48 h. The mechanism of drug release by combination gel was Higuchi+ fickian with values of n (0.282) and R2 (0.947). An in vivo study for pain assessment via four methods: (i) heat hyperalgesia, (ii) cold allodynia, (iii) mechano-hyperalgesia, and (iv) dynamic mechano-allodynia, confirmed that topical treatment with co-combination gel reduced the pain significantly as indicated by the p value: R1 (p < 0.001), R2 (p < 0.001), R3 (p < 0.015), and R4 (p < 0.0344). The significance order was R2 (****) > R1 (***) > R3 (**) > R4 (*) > R5 (ns).

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Section: Resultssupporting

confidence: 92%

Section: Effect Of Different Pregabalin and Withania Coagulans Combin...supporting

confidence: 90%

Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

Asghar

Aamir

Sheikh³

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…To uncover the main curative agent, it is necessary to identify the biologically active constituents of medicinal plants. 39,40 Several acetylcholinesterase inhibitors such as donepezil, galantamine, piracetam, and rivastigmine have been used for AD management. However, because they offer only symptomatic relief and/or due to their side effects, no agreeable treatment is currently available for AD.…”

Section: Discussionmentioning

confidence: 99%

The Neuroprotective Propensity of Organic Extracts of Acacia stenophylla Bark and Their Effectiveness Against Scopolamine-/Diazepam-Induced Amnesia in Mice

Shah¹,

Iqbal²,

Alshehri³

et al. 2022

JIR

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Background: Alzheimer's disease (AD) is a neurodegenerative disorder that is more prevalent in the elderly. There is extensive literature on using Acacia species against central nervous system disorders, although Acacia stenophylla has not been investigated for any neuroprotective potential. The purpose of the study was to elucidate the ameliorative effect of ethyl acetate (ASEE) and butanol (ASB) extracts from the bark of A. stenophylla on memory deficits and cognitive dysfunction in scopolamine-or diazepam-induced amnesia in mice. Methods: The phytochemical constituents of the extracts of A. stenophylla were determined by GC-MS and the in vitro anticholinesterase plus antioxidant activities were also evaluated. Anti-amnesic effects were determined employing the open field test, elevated plus maze (EPM), Morris water maze (MWM), and Y-maze paradigms. Results: The in vitro cholinesterase assays disclosed a concentration-dependent inhibition of both AChE and BuChE with IC 50 values of 28.48 and 44.86 µg/mL for the ASEE extract and 32.04 and 50.26 µg/mL for the ASB extract against AChE and BuChE respectively. DPPH and H 2 O 2 antioxidant assays revealed respective IC 50 values for the ASEE extract of 28.04 and 59.84 µg/mL, plus 32.77 and 64.65 µg/mL for ASB extract. The findings revealed that both extracts possessed substantial antioxidant properties. Furthermore, these fractions restored scopolamine-and diazepam-induced memory deficits in a dose-dependent manner, as observed by a significant decrease in the transfer latency in EPM, reduction in escape latency, added time spent in the target quadrant in the MWM, and elevated spontaneous alternation behavior (SAB) in the Y-maze test. Conclusion:The ameliorative effect of A. stenophylla on scopolamine-and diazepam-induced amnesia can be attributed to antioxidant and anticholinesterase activity. Consequently, the use of A. stenophylla might be exploited in the alleviation of oxidative stress and the management of AD.

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6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression

Shahid,

Subhan,

Ahmad

et al. 2024

Biochemical and Biophysical Research Communications

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Cassia artemisiodes attenuates nociceptive and diabetes-induced neuropathic pain modalities apropos antioxidant and anti-inflammatory mechanisms

Cited by 11 publications

References 51 publications

Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

The Neuroprotective Propensity of Organic Extracts of Acacia stenophylla Bark and Their Effectiveness Against Scopolamine-/Diazepam-Induced Amnesia in Mice

6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression

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