Caspofungin treatment in severely ill, immunocompromised patients: a case-documentation study of 118 patients

Glasmacher, Axel; Cornely, Oliver A.; Orlopp, K.; Reuter, Stefan; Blaschke, Sarah; Eichel, Margaret; Silling, Gerda; Simons, Benjamin D.; Egerer, Gerlinde; Siemann, Maria Eugênia; Florek, Marzena; Schnitzler, Robert N.; Ebeling, Peter R.; Ritter, J.; Reinel, H.; Schütt, Philipp; Fischer, Harald E.; Hahn, Christian; Just-Nuebling, Gudrun

doi:10.1093/jac/dki410

Cited by 37 publications

(29 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both surveys show that the common species-C. albicans, C. glabrata, and C. tropicalis-are highly susceptible to all three agents, whereas elevated MICs (1 g/ml to 4 g/ml) are seen for C. parapsilosis and C. guilliermondii. The available clinical data indicate that these species respond similarly to treatment with each of these agents (29,41,87,114,119,163,184,219,274); however, it should be noted that persistent fungemia with C. parapsilosis has been observed in the face of caspofungin therapy (163). In light of these findings, it is also important to know that caspofungin has been shown to lack fungicidal activity against C. parapsilosis (and C. guilliermondii) (17a).…”

Section: Trends In Antifungal Susceptibility In Relation To Time Geomentioning

confidence: 99%

“…As the first of the echinocandins to be approved for the treatment of IC, caspofungin has been used extensively for the treatment of all forms of serious candidal infections over the past 4 years (87,114,134,171,261). Thus far, clinical experience with caspofungin and IC has been good (41,87,114,163,171).…”

Section: Trends In Antifungal Susceptibility In Relation To Time Geomentioning

confidence: 99%

“…Thus far, clinical experience with caspofungin and IC has been good (41,87,114,163,171). However, recent reports describing the emergence of caspofungin resistance during treatment of esophagitis (102), candidemia (63,120), and endocarditis (167) raise concerns about the emergence of caspofungin-resistant Candida spp.…”

Section: Trends In Antifungal Susceptibility In Relation To Time Geomentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

2007

View full text Add to dashboard Cite

SUMMARY Invasive candidiasis (IC) is a leading cause of mycosis-associated mortality in the United States. We examined data from the National Center for Health Statistics and reviewed recent literature in order to update the epidemiology of IC. IC-associated mortality has remained stable, at approximately 0.4 deaths per 100,000 population, since 1997, while mortality associated with invasive aspergillosis has continued to decline. Candida albicans remains the predominant cause of IC, accounting for over half of all cases, but Candida glabrata has emerged as the second most common cause of IC in the United States, and several less common Candida species may be emerging, some of which can exhibit resistance to triazoles and/or amphotericin B. Crude and attributable rates of mortality due to IC remain unacceptably high and unchanged for the past 2 decades. Nonpharmacologic preventive strategies should be emphasized, including hand hygiene; appropriate use, placement, and care of central venous catheters; and prudent use of antimicrobial therapy. Given that delays in appropriate antifungal therapy are associated with increased mortality, improved use of early empirical, preemptive, and prophylactic therapies should also help reduce IC-associated mortality. Several studies have now identified important variables that can be used to predict risk of IC and to help guide preventive strategies such as antifungal prophylaxis and early empirical therapy. However, improved non-culture-based diagnostics are needed to expand the potential for preemptive (or early directed) therapy. Further research to improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC.

show abstract

Section: Trends In Antifungal Susceptibility In Relation To Time Geomentioning

confidence: 99%

Section: Trends In Antifungal Susceptibility In Relation To Time Geomentioning

confidence: 99%

Section: Trends In Antifungal Susceptibility In Relation To Time Geomentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

2007

View full text Add to dashboard Cite

show abstract

“…Outcome is better if patients have well-controlled underlying disease and granulocyte count greater than 1000 [13] Amphotericin B, fluconazole, itraconazole and variconazole have been used with success in several cases of pulmonary or invasive aspergillosis [2] with different effective rates. In 2006, Glasmacher et al reported the efficacy and safety of Caspofungin (CF) in a large unselected population of patients with fungal infections in Germany [14]. CF, which is the first-in-echinocandin class, is an antifungal drug with a broad spectrum of activity and excellent tolerbility.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary aspergillosis in a patient with COPD due to PEG-interferon and ribavirin therapy for chronic hepatitis C

Ersoy¹,

Eser²,

Seyhmus³

et al. 2013

CRCM

View full text Add to dashboard Cite

This is a case of 52 years old male patient with chronic obstructive pulmonary disease (COPD) who developed semi-invasive pulmonary aspergillosis while on pegylated-interferon alpha-2a and for chronic hepatitis C infection. This complication is very rarely seen during interferon therapy for other any purposes. Pulmonary aspergillosis in particular group of chronic hepatitis C patients under immunosupressive therapy should also be in mind and interdisciplinary medical cooperation might be needed during the treatment for immune-suppressed patients. Pulmonary aspergillosis is also discussed from many aspects in the light of the literature.

show abstract

“…The alternatives include high-dose liposomal amphotericin B, echinocandins, or the newer azole drugs, such as itraconazole or voriconazole [11] . Caspofungin has been shown to be efficacious during empirical antifungal therapy for neutropenic patients or severely ill patients with refractory invasive Aspergillus infections and invasive candidiasis [12] .…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Fatal Disseminated Invasive Aspergillosis and Pyoderma Gangrenosum: A Case Report

Yang¹,

Hsu²,

Cheng³

et al. 2011

Med Princ Pract

View full text Add to dashboard Cite

Objective: To report an unusual case of disseminated aspergillosis involving the lymph nodes, lungs, and skin in a patient with pyoderma gangrenosum (PG) and myelodysplastic syndrome (MDS). Case Presentation and Intervention: A 46-year-old man presented with productive cough of 2 weeks’ duration. Besides, several painless, fixed lymph nodes were palpated at his left neck. He had PG and MDS diagnosed in June 2004 with regular use of oral dapsone and prednisolone. His skin lesions healed with scar formation and no purulent discharge. A computed tomography scan of the head, neck and chest showed bilateral lung consolidation and abscesses at the left neck, right upper lung and right pleura. The neck abscess culture grew Aspergillus species. Dark reddish macules developed over the right arm, chest and abdominal wall, and the left lower limb 2 weeks after initiation of amphotericin B. The histology of the right arm skin biopsy showed invasive aspergillosis. Caspofungin was started then for suspicion of poor response to amphotericin B. He expired despite 35 days of antifungal therapy. Conclusion: This report highlights the rarity of coexistence of disseminated aspergillosis and PG, and should alert physicians to the possibility of invasive fungal infection superimposed on a chronic skin lesion.

show abstract

Caspofungin treatment in severely ill, immunocompromised patients: a case-documentation study of 118 patients

Abstract: This open case study of severely ill patients with invasive fungal infections demonstrates both excellent efficacy and very low toxicity of caspofungin.

Cited by 37 publications

References 18 publications

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

Pulmonary aspergillosis in a patient with COPD due to PEG-interferon and ribavirin therapy for chronic hepatitis C

Coexistence of Fatal Disseminated Invasive Aspergillosis and Pyoderma Gangrenosum: A Case Report

Contact Info

Product

Resources

About