Cashing in on ferroptosis against tumor cells: Usher in the next chapter

Valashedi, Mehdi Rabiee; Najafi-Ghalehlou, Nima; Nikoo, Amirsadegh; Bamshad, Chia; Tomita, Kazuo; Kuwahara, Yoshikazu; Sato, Tomoaki; Roushandeh, Amaneh Mohammadi; Roudkenar, Mehryar Habibi

doi:10.1016/j.lfs.2021.119958

Cited by 18 publications

(7 citation statements)

References 176 publications

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“…The external pathway is initiated by inhibiting cell membrane transporters such as cystine/glutamate transporters (also known as the XC-system) or by activating serum and milk transferrin. The internal pathway is activated by blocking intracellular antioxidant enzymes such as GPX4 [ 47 ]. GPX4 uses glutathione (GSH) as a reduction cofactor to reduce lipid hydroperoxides to lipid alcohols.…”

Section: Discussionmentioning

confidence: 99%

Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis

Zhou

Liu

Zhang

et al. 2023

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis

Zhou

Liu

Zhang

et al. 2023

Bioactive Materials

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“…Although the combination of ferroptosis and PDTinduced immunotherapy holds promise for long-term tumor control, several issues remain to be resolved. The inflammatory response of phagocytes may inhibit antitumor immunity and stimulate tumor growth [53]. Thus, further research is required to elucidate the distinct roles of both in tumor immunity.…”

Section: Rsl3 Rsl3 Is a Ferroptosis Activator That Induces Ferroptosi...mentioning

confidence: 99%

Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy

Zeping

Zheng

Kamei

et al. 2022

Acta Materia Medica

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Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate reactive oxygen species and aggravate oxidative stress in tumor cells. Combining ferroptosis with PDT cooperatively regulates intracellular redox homeostasis, thus increasing cancer cell susceptibility to oxidative stress and yielding synergistic anticancer effects. In this review, various strategies for combining ferroptosis with PDT are comprehensively summarized and discussed, including mono-PDT and PDT-induced ferroptosis, combining PDT with small-molecule ferroptosis inducers, and combining PDT with metal-ion-induced ferroptosis. Additionally, the possibility of combining ferroptosis and PDT with other anti-tumor therapies is discussed. Finally, the prospects and challenges of combining ferroptosis with PDT in clinical cancer treatment are addressed. With increased understanding of the superiority of combination PDT with ferroptosis for cancer treatment, we hope that drug delivery systems based on this strategy will be further developed to increase anticancer efficiency and achieve successful clinical translation.

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“…Selective induction of cancer cell death is one of the most effective treatment methods for tumors. One such method is ferroptosis, which is closely related to various diseases, especially cancer, and plays a key role in all aspects of cancer biology and drug resistance (6). Ferroptosis is a new type of non-apoptosis regulated cell death that inhibits or promotes tumor progression by releasing a variety of signaling molecules in the tumor microenvironment (7).…”

Section: Original Articlementioning

confidence: 99%

Analysis and prediction model of ferroptosis related genes in breast cancer

Wang¹,

Chen²,

Zhao³

et al. 2022

Transl Cancer Res TCR

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Background: The prognosis of patients with breast cancer (BRCA) is difficult to predict because of the high degree of heterogeneity and complex etiological factors. Ferroptosis, an iron-dependent, new form of cell death, plays an important role in regulation of tumor growth and progression. The aim of this study was to clarify the predictive value of ferroptosis-related genes in the overall survival of patients with BRCA. Methods:The messenger RNA expression profile and clinical information of patients with BRCA were collected from The Cancer Genome Atlas (TCGA) database. The differences between BRCA and adjacent normal tissues were analyzed, and candidates with differentially expressed ferroptosis-related genes were identified. Through Cox and LASSO analyses, the prognostic genetic characteristics of ferroptosis-related genes were established. Lastly, according to the median risk score, the patients were divided into high-risk and low-risk groups, a nomogram was constructed, and the prediction accuracy was tested.Results: It was determined that the four ferroptosis related genes had a significant difference in survival in BRCA (P<0.05); a prognostic model was constructed based on the four ferroptosis related genes, and the overall survival of patients in the high-risk group was significantly worse (P<0.05). The four-gene nomogram can quantify the contribution of each index to survival, and the calibration chart shows high prediction accuracy.Conclusions: This study constructed four ferroptosis related gene characteristics and nomogram, which can effectively predict the prognosis of BRCA patients and provide new insights for future anti-cancer treatments based on ferroptosis targets.

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Cashing in on ferroptosis against tumor cells: Usher in the next chapter

Cited by 18 publications

References 176 publications

Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis

Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis

Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy

Analysis and prediction model of ferroptosis related genes in breast cancer

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