Casein Microgels as Benzydamine Hydrochloride Carriers for Prolonged Release

Milenkova, Sofia; Pilicheva, Bissera; Uzunova, Yordanka; Yovcheva, T.; Marudova, Maria

doi:10.3390/ma15041333

Cited by 5 publications

(4 citation statements)

References 41 publications

(42 reference statements)

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“…It demonstrated no burst effect of surface-adhered drug. This release profile was close to the results, obtained by us for Benz loaded in crosslinked casein particles [22], and completely different from the release profile from crosslinked chitosan particles [23].…”

Section: Formation and Characterization Of Cas/ch Nanocomplexessupporting

confidence: 78%

Formulation and characterization of Benzydamine loaded casein/chitosan nanocomplexes

Marudova

Milenkova

Zahariev

et al. 2023

J. Phys.: Conf. Ser.

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The objectives of the present study were to synthesize casein/chitosan nanocomplexes, which are able to immobilize and release Benzydamine in a controlled manner, and to investigate the influence of casein/chitosan ratio on their morphological, physico-chemical and drug carrier characteristics. The complexes were obtained by electrostatic interaction at pH 6, at which casein in negatively charged and chitosan is protonated. The yield of the complexation was the lowest for chitosan excess particles (18.4%) and increased to 83.5% for casein excess particles. The particle size varied in the range from 400 nm to several microns depending on the casein/chitosan ratio. Atomic force microscopy (AFM) was used to assess the morphological properties of the nanocomplexes. It was found that the Benzydamine loading was minimal (15%) in the stoichiometric complex and maximal (30%) in complexes with casein/chitosan ratio 5:1. The mechanism of Benzydamine release was defined as Fickian diffusion.

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Section: Formation and Characterization Of Cas/ch Nanocomplexessupporting

confidence: 78%

Formulation and characterization of Benzydamine loaded casein/chitosan nanocomplexes

Marudova

Milenkova

Zahariev

et al. 2023

J. Phys.: Conf. Ser.

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“…Casein proteins contain both hydrophobic and hydrophilic regions and have a porous structure with cavities and channels that allow them to entrap more polyphenols to form stable complexes or conjugates as compared to whey proteins [30]. These unique structural properties also make caseins appropriate for delivering other bioactive components and drugs, including vitamins, omega-3 fatty acids, and drug molecules, including benzydamine, celecoxib, doxorubicin, ibuprofen, metformin, paclitaxel, and ritonavir [31][32][33][34][35][36][37][38][39][40][41]. The order of protein affinity towards tea polyphenols was caseins > β-lactoglobulin, as reported by Chanphai et al [42].…”

Section: Preferential Binding and The Competition Of Polyphenols For ...mentioning

confidence: 99%

Preferential Binding of Polyphenols in Blackcurrant Extracts with Milk Proteins and the Effects on the Bioaccessibility and Antioxidant Activity of Polyphenols

Mao,

Akshit,

Matiwalage

et al. 2024

Foods

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Milk proteins are well-known delivery agents; however, there is no clear understanding of the competitive interactions of milk proteins with polyphenols in mixed complex systems. Here, we investigate the preferential competitive interactions of different polyphenols present in blackcurrant extract with milk proteins by quantifying the protein-bound polyphenols and comparing the factors affecting these interactions. In addition, bioaccessibility and antioxidant activity were studied after in vitro gastric digestion. Our results indicated that polyphenols from blackcurrant extracts were preferentially bound to caseins more than whey proteins, with noncovalent interactions causing secondary structural changes in the protein. The hydrophobicity and the charge of the polyphenols were negatively and positively related to the number of polyphenols bound to casein and whey proteins, respectively. Moreover, the bioaccessibility and antioxidant activity of polyphenols were enhanced in the presence of milk proteins in milk-based blackcurrant samples when compared to polyphenol and protein-alone samples in the in vitro gastric phase. These findings underscore the critical role of milk proteins in encapsulating or delivering polyphenols. This will pave the way for boosting the bioavailability of polyphenols by complexing them with milk proteins and formulating functional dairy foods, integrating the beneficial effects of these compounds.

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“…Due to its predominant local therapeutic activity, an appropriate mode and route of administration should be selected. Polymer-based structures such as planar films [ 4 ], multilayered films [ 5 ], wafers [ 2 ], and nano- and micro-particles [ 1 , 6 ] have been widely employed to achieve optimal local therapeutic effects with minimum side effects and local irritation.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the aim of the present study is to prepare chitosan-based gel particles with sizes below 30 µm and load them with benzydamine hydrochloride. In our previous studies [ 6 , 18 ], we have developed polymeric particles using spray drying and ionic gelation techniques on the base of casein. In the case of spray-dried particles, the thermal instability of the protein has led to the need to conduct the preparation process at relatively low temperatures.…”

Section: Introductionmentioning

confidence: 99%

Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride

Milenkova,

Ambrus,

Mukhtar

et al. 2024

Gels

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Chitosan, being a biocompatible and mucoadhesive polysaccharide, is one of the most preferred hydrogel-forming materials for drug delivery. The objectives of the present study are to obtain spray-dried microparticles based on low-molecular-weight chitosan and study their potential application as cargo systems for the orally active drug benzydamine hydrochloride. Three types of particles are obtained: raw chitosan particles (at three different concentrations), cross-linked with sodium tripolyphosphate (NaTPP) particles (at three different chitosan:NaTPP ratios), and particles coated with mannitol (at three different chitosan:mannitol ratios), all of them in the size range between 1 and 10 µm. Based on the loading efficiency and the yields of the formulated hydrogel particles, one model of each type is chosen for further investigation of the effect of the cross-linker or the excipient on the properties of the gel structures. The morphology of both empty and benzydamine hydrochloride-loaded chitosan particles was examined by scanning electron microscopy, and it was quite regular and spherical. Interactions and composition in the samples are investigated by Fourier-transformed infrared spectroscopy. The thermal stability and phase state of the drug and drug-containing polymer matrixes were tested by differential scanning calorimetry and X-ray powdered diffraction, revealing that the drug underwent a phase transition. A drug release kinetics study of the chosen gel-based structures in simulated saliva buffer (pH = 6.8) and mathematical modeling of the process were performed, indicating the Weibull model as the most appropriate one.

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Casein Microgels as Benzydamine Hydrochloride Carriers for Prolonged Release

Cited by 5 publications

References 41 publications

Formulation and characterization of Benzydamine loaded casein/chitosan nanocomplexes

Formulation and characterization of Benzydamine loaded casein/chitosan nanocomplexes

Preferential Binding of Polyphenols in Blackcurrant Extracts with Milk Proteins and the Effects on the Bioaccessibility and Antioxidant Activity of Polyphenols

Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride

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