Case Study for Selected Heavy Elements in Blood and Plasma from Six Female Patients with Systemic Sclerosis (Scleroderma, SSc). The Concentrations of Mercury, Lead, Antimony, Cobalt, Copper, and Zinc

Tamasi, Gabriella; Bellini, Marta; Lorenzini, Sauro; Chindamo, Daniela; Marcolongo, R; Baroni, Fabio; Riccobono, Francesco; Netti, R; Cini, Renzo

doi:10.2174/1874065000802010055

Cited by 2 publications

(1 citation statement)

References 23 publications

(22 reference statements)

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“…Suva materija je na nivou oko 57% (oko 12 kg). Prema kalkulaciji dnevni unos selena iznosi 0,2 mg/kg suve materije (a preporuka prema NRC-u 0,3), a dnevni unos cinka iznosi oko 30 mg/kg suve materije (a preporuka prema NRC-u je [40][41][42][43][44][45][46][47][48][49][50]. Dakle u obroku su postojale suboptimalne vrednosti selena i cinka.…”

Section: žIvotinje / Animalsunclassified

The influence of selenium and zinc addition in food on concentration of these elements in blood and milk, on somatic cells number and histological characteristics of cows udders

Davidov¹,

Cincović²,

Radinović³

et al. 2014

VET GLASNIK

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The experiment included 30 cows of Holstein-Friesian breed, out of which 15 were receiving selenium and zinc in optimal doses before calving, while the others had never been supplemented with these micronutrients. There was analysed the concentration of selenium and zinc in blood and milk serum as well as the average number of somatic cells in corresponding lactation. After the cows exclusion from production, histological characteristics of cows udders were examined. The results of the investigation have shown that addition of selenium and zinc before calving has a positive effect on the values of these microelements in the blood and milk during the period of early lactation, that is, the concentration of these elements was significantly higher in the blood and milk of the cows that obtained selenium and zinc supplements. Also, in these cows there was significantly lower number of somatic cells during the following lacation period. In the parenchyma of the udder there was found less pronounced infiltration of leukocytes, notably thicker keratin layer of ductus papillaris and less expressed repairing processes that indicate a chronic inflammation of the udder in the samples after exclusion of the cows from production. There was a significant positive correlation between selenium in blood and milk, while there was not observed such a correlation for zinc. On the other hand, there was a significant negative correlation between the concentration of selenium in the blood and milk with the average number of somatic cells and the degree of infiltration of leukocytes, while its influence on the keratin layer of ductus papillarus was not shown. Zinc from blood and udder had a negative correlation with the number of somatic cells, had a positive correlation with the thickness of ductus papillaris keratin layer and had no influence on the level of leukocyte infiltration of udder parenchyma. Zinc demonstrates a positive influence on the formation of ductus papillaris keratin layer and protects the udder from pathogens penetration, while selenium stimulates the immunological response of the udder. Their positive impact can be defined as additive, because athough they have effect on two morphologically separate udder parts, adding both of them significantly decreases the number of somatic cells in milk. [Projekat Ministarstva nauke Republike Srbije, br. TR31062]

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Section: žIvotinje / Animalsunclassified

The influence of selenium and zinc addition in food on concentration of these elements in blood and milk, on somatic cells number and histological characteristics of cows udders

Davidov¹,

Cincović²,

Radinović³

et al. 2014

VET GLASNIK

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Association Between Exposure to Heavy Metals and Systemic Sclerosis: the Levels of Al, Cd, Hg, and Pb in Blood and Urine of Patients

Forte¹,

Bocca³

et al. 2018

Biol Trace Elem Res

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Systemic sclerosis (SSc) is a multisystem connective tissue disease; exogenous factors-including heavy metals-may have a role in the disease pathogenesis. In this context, a study on the quantification of Al, Cd, Hg, and Pb in blood and urine of 27 SSc patients and 30 controls was carried out. Main findings were that Al was significantly depleted in blood and increased in urine of SSc patients respect to controls; and Pb was found slightly increased in blood and significantly decreased in SSc group. In addition, higher Hg levels in urine were found in SSc subjects with the higher severity of the disease. Females showed the most marked differences in the levels of blood Al, blood Pb, and urine Cd between patients and controls. Smoking, hobby, ingestion of contaminated food, job exposure may contribute to the bodily levels of Al, Hg, Pb in SSc patients. The results indicated that low, chronic, and multiple exposures to heavy metals-also through habits, diet, and environment-may influence the risk for SSc.

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Case Study for Selected Heavy Elements in Blood and Plasma from Six Female Patients with Systemic Sclerosis (Scleroderma, SSc). The Concentrations of Mercury, Lead, Antimony, Cobalt, Copper, and Zinc

Cited by 2 publications

References 23 publications

The influence of selenium and zinc addition in food on concentration of these elements in blood and milk, on somatic cells number and histological characteristics of cows udders

The influence of selenium and zinc addition in food on concentration of these elements in blood and milk, on somatic cells number and histological characteristics of cows udders

Association Between Exposure to Heavy Metals and Systemic Sclerosis: the Levels of Al, Cd, Hg, and Pb in Blood and Urine of Patients

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