Case series of patients with chronic foot ulcers treated with autologous platelet‐rich plasma

Yotsu, Rie Roselyne; Hagiwara, Shotaro; Okochi, Hitoshi; Tamaki, Takeshi

doi:10.1111/1346-8138.12777

Cited by 20 publications

(24 citation statements)

References 43 publications

(76 reference statements)

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“…57 PRP has shown to be effective at propagating new healthy tissue growth in a wide range of medical conditions, such as venous ulcers, diabetic foot ulcers, and tendinopathy. [58][59][60][61][62] Outside of one-patient case reports, there have been few studies investigating the use of PRP in patients with biopsy-proven LS. [63][64][65] A 2010 study examined injections of a combination of PRP and fat-derived mesenchymal cells in 15 women with vulvar LS.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

<p>Vulvar Lichen Sclerosus: Current Perspectives</p>

Krapf

Mitchell

Holton

et al. 2020

IJWH

105

145

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Vulvar lichen sclerosus (LS) is a chronic, inflammatory dermatosis that may lead to scarring of the vulva and sexual dysfunction. LS affects women of all ages and often goes unrecognized and underreported. Uncertainty continues to exist around its pathogenesis, histologic diagnosis, and treatment. However, there have been great advances in our understanding of autoimmunogenic targets in disease formation and progression. In addition, there has been recent investigation of potential non-steroid-based treatments, including plateletrich plasma therapy and energy-based modalities such as the fractional CO 2 laser, photodynamic therapy, and high intensity focused ultrasound. Refinement of surgical techniques for restoring vulvar anatomy and treating clitoral phimosis, introital stenosis, and vulvar granuloma fissuratum is leading to improved patient outcomes. This review summarizes current perspectives on the pathogenesis, symptomatology, diagnosis, and treatment for vulvar lichen sclerosus.

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Section: Platelet-rich Plasmamentioning

confidence: 99%

<p>Vulvar Lichen Sclerosus: Current Perspectives</p>

Krapf

Mitchell

Holton

et al. 2020

IJWH

105

145

View full text Add to dashboard Cite

show abstract

“…77 Topical applications of autologous PRP have rendered unique advantages, especially for refractory wounds. 78 The advantages of PRP may originate mainly from the release of highly concentrated cytokines, growth factors, and antibacterial proteins. 79 Cytokines and growth factors are helpful for cellular proliferation, migration, and the differentiation of fibroblasts, endothelial cells, and keratinocytes.…”

Section: Treatment For Chronic Ulcersmentioning

confidence: 99%

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Zhang

Guo

Kuss

et al. 2019

Tissue Engineering Part B: Reviews

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The management and treatment of tissue infection, especially chronic infection, represents a significant challenge. Application of autologous platelet-rich plasma (PRP) has emerged as a promising adjunct therapy for facilitating the healing of surgical wounds and tissue injuries. PRP is extracted from whole blood using a sequential centrifugation technique and when activated, can release a vast array of antimicrobial proteins, cytokines, and growth factors. These bioactive molecules are responsible for the ability of PRP to kill pathogens, resolve necrotic tissue, and promote wound healing. PRP is emerging as a useful supplement to prevent postoperative infection and treat chronic wound or bone infections. PRP displays a synergistic effect with antibiotics, which provides unique advantages when treating antibiotic-resistant bacteria. This review will describe the method for PRP preparation and its antibacterial properties, as well as discuss both preclinical in vivo results and evidence from clinical practice of PRP use for the treatment of wound and bone infections.

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“…For several decades, PRP has provided a promising alternative to traditional methods by promoting safe and natural healing [12]. The combination of autologous PRP, subcutaneously and topically, and the optimized diet opens a new therapeutic window for treatment of the chronic wounds.…”

Section: Resultsmentioning

confidence: 99%

A Holistic Approach and Successful Treatment of Chronic Wound in Diabetes Mellitus by Platelet-Rich Plasma (PRP) Combined with Optimized Diet

Bolouri¹,

Hajimirsadeghi²

2017

Dermatol Case Rep

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The underlying pathomechanisms of delayed wound healing in patients with diabetes mellitus is still a frequent and very severe problem. From a holistic point of view however, contemporary management of chronic wounds attempts to improve natural healing and individualization of treatment. Herein, we report an effective usage of platelet-rich plasma (PRP), both subcutaneously and topically, in combination with an optimized glycemic control diet in a chronic and nonhealing wound. Over 26 weeks, a patient diagnosed with diabetes mellitus had received multiple therapies in attempt to heal a severe leg wound. The introduction to PRP therapy and the daily usage of the PRP gel topically led to an approximately 30% reduction in wound size over 12 days. Optimization of the patient's diet was eventually added to the treatment protocol after seeing the first improvement in wound healing. A weight loss was observed during the treatment period from 105 kg pre-treatment to 88 kg post-treatment, respectively. The prompt and promising outcome of this protocol indicates hope for the patients with chronic wounds and the urge of the further studies with holistic approaches.

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Case series of patients with chronic foot ulcers treated with autologous platelet‐rich plasma

Cited by 20 publications

References 43 publications

<p>Vulvar Lichen Sclerosus: Current Perspectives</p>

<p>Vulvar Lichen Sclerosus: Current Perspectives</p>

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

A Holistic Approach and Successful Treatment of Chronic Wound in Diabetes Mellitus by Platelet-Rich Plasma (PRP) Combined with Optimized Diet

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