Case Series and Mini-Review on Elizabethkingia meningoseptica, A high
Alert Organism Causing Meningitis in Premature Neonates from A Tertiary
Care Hospital of Western Rajasthan

Abhishek, Kumar S; Kombade, Sarika P; Gupta, Neeraj; Tak, Vibhor; Nag, Vijaya Lakshmi; Singh, Kuldeep; Agarwal, Nidhima

doi:10.2174/1871526520666210104151430

Cited by 3 publications

(2 citation statements)

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“…The majority of these organisms are E. coli or Klebsiella isolates; however, other gram-negatives have emerged as multidrug-resistant threats. These multidrug-resistant GNB run the gamut from common pathogens such as Salmonella and Serratia all the way to Ewingella, Elizabethkingia, Pantoea, and Chryseobacterium spp [30][31][32][33][34][35][36][37][38][39][40]. Perhaps the most concerning trend in gram-negative neonatal infections has been the arrival of carbapenem-resistant organisms [41].…”

Section: Gram-negativementioning

confidence: 99%

Neonatal bloodstream infections

Hadfield¹,

Cantey²

2021

Current Opinion in Infectious Diseases

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Purpose of review Neonatal bloodstream infections (BSI) are a major contributor to morbidity and mortality within neonatal intensive care units. BSI, including central line-associated BSI, have decreased over the past 15 years but remain common in extremely preterm infants. The purpose of this review is to highlight recent advances in the causes, diagnosis, management, and prevention of neonatal BSI. Recent findings Continued quality improvement efforts and bundles have reduced BSI incidence, and novel approaches are highlighted. An update of emerging pathogens as well as traditional pathogens with novel antimicrobial resistance, which are an increasingly common cause of neonatal BSI, is included. Finally, current and future investigations into serum or noninvasive biomarkers for neonatal BSI are reviewed. Summary Neonatal BSIs continue to decrease due to enhanced infection control and prevention techniques. However, many challenges remain, including emerging bacterial and fungal resistance and the continued need for novel diagnostics that hasten time to pathogen identification and effective treatment. This review of the past 18 months highlights the rapid changes in this area. Ongoing efforts to reduce the morbidity and mortality caused by neonatal BSI must remain a priority.

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Section: Gram-negativementioning

confidence: 99%

Neonatal bloodstream infections

Hadfield¹,

Cantey²

2021

Current Opinion in Infectious Diseases

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“…Only a few reports of E. meningoseptica sepsis outbreaks have recently been described from neonatal intensive care settings, primarily as isolated cases. [5][6][7][8][9][10] To effectively control these outbreaks often, the involvement of all key stakeholders, including clinicians and the hospital infection control team, is essential. A collaborative plan needs to be devised, encompassing various measures for identification potential sources, implementation of broad-spectrum infection control measures as well as prompt treatment with appropriate antibiotics.…”

mentioning

confidence: 99%

Elizabethkingia meningoseptica Outbreak in NICU: An Observational Study on a Debilitating Neuroinfection in Neonates

Swami,

Mude,

Kar

et al. 2023

Pediatric Infectious Disease Journal

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Background: Elizabethkingia meningoseptica is an emerging nosocomial pathogen implicated in neonatal sepsis with high mortality and morbidities. However, there is very limited data regarding the characteristics as well as outcomes following this infection, particularly in developing countries. Methods: We conducted a retrospective observational study of all infants with culture-positive Elizabethkingia sepsis as part of an outbreak, to study their clinical and epidemiological characteristics, as well as their antimicrobial susceptibility patterns, using a structured proforma from the neonatal intensive care unit database. Analysis was done using descriptive statistics and predictors of mortality and hydrocephalus were also identified. Results: Of the 21 neonates enrolled, 9 (42.9%) were male, with a mean gestational age and birth weight of 31.7 ± 3.4 weeks and 1320 ± 364 g, respectively. The median (interquartile range) age of onset of illness was 7 (5–12) days. The overall mortality rate was 23.8%, and among survivors, 50% had neurologic complications requiring intervention. Vancomycin and ciprofloxacin were the most used antibiotics for treatment in our series, with a median duration of 26 (17–38) days. On univariate analysis, shock at presentation was significantly associated with increased mortality (P = 0.04) while, seizures (P = 0.04) and elevated cerebrospinal fluid protein levels (P = 0 .01) at onset of illness predicted progressive hydrocephalus in surviving neonates. Conclusion: E. meningoseptica sepsis is associated with high morbidity and mortality. Early diagnosis and prompt initiation of appropriate antibiotics are critical for improving survival and neurodevelopmental outcomes. Though isolation of the organism by environmental surveillance is always not possible, with proper infection control measures, the infection can be controlled.

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Neonatal Meningitis Outbreak by Elizabethkingia: A Case Series and Epidemiological Investigation Findings

Francis,

Balasundaran,

Kumar

et al. 2023

Journal of Neonatology

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This study is a case series ( n = 7) of neonatal meningitis caused by Elizabethkingia at a tertiary-level hospital in South India. All cases occurred in premature and low-birth-weight neonates over a short period of 4 months, constituting an outbreak. The bacterial pathogen was identified in cerebrospinal fluid (CSF) in all cases and was found to be sensitive to vancomycin and ciprofloxacin. All neonates survived, but one developed ventriculomegaly. The outbreak was investigated, but the source of contamination was not identified in the environment. However, new cases ceased to occur after revamping the feeding practices. Hence, it was assumed that the feeding utensils might have been the source of contamination. The study highlights the importance of source elimination and implementing appropriate infection control measures in neonatal intensive care units (NICU).

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Case Series and Mini-Review on Elizabethkingia meningoseptica, A high Alert Organism Causing Meningitis in Premature Neonates from A Tertiary Care Hospital of Western Rajasthan

Cited by 3 publications

References 0 publications

Neonatal bloodstream infections

Neonatal bloodstream infections

Elizabethkingia meningoseptica Outbreak in NICU: An Observational Study on a Debilitating Neuroinfection in Neonates

Neonatal Meningitis Outbreak by Elizabethkingia: A Case Series and Epidemiological Investigation Findings

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