Case Report: Retinitis Pigmentosa Following Cytotoxic Chemotherapy in Usher’s Syndrome

Blanchet, Paulette; Wellemeyer, Mark; Burton, Gary V.

doi:10.1097/00000441-199205000-00010

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…Retinitis pigmentosa, the most common hereditary retinal degeneration, typically begins with night blindness and may be associated with abnormal cilia and disrupted OS renewal (Young 1977;Arden and Fox 1979;Dryja and Berson 1995). The present study corroborates other recent research (Barrong et al 1992;Berson and Adamian 1992;Blanchet et al 1992;Weil et al 1995) supporting a ciliary pathology in some forms of retinitis pigmentosa: lower stability of the ciliary axoneme in rods than cones may contribute to the higher susceptibility of rods to degeneration.…”

Section: Resultssupporting

confidence: 92%

Renewal of the ciliary axoneme in cone outer segments of the retina of Xenopus laevis

Eckmiller

1996

Cell and Tissue Research

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The ciliary axoneme in photoreceptors from the retina of Xenopus laevis was examined by immunofluorescent staining of tubulin throughout the light/dark cycle. The immunofluorescent axoneme extended along only part of the length of rod outer segments but the entire length of cone outer segments. Both the cone axoneme and outer segment elongated during the day and shortened (presumably by shedding) during the night. Fragments of immunofluorescent axonemes were found within packets of outer segment material breaking off from cone tips. These findings show that the ciliary axoneme in the Xenopus retina is replaced during the renewal of outer segments in cones. No evidence has been found for renewal of the axoneme in rods, and thus the stability of the ciliary axoneme may differ in rod and cone photoreceptors.

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Section: Resultssupporting

confidence: 92%

Renewal of the ciliary axoneme in cone outer segments of the retina of Xenopus laevis

Eckmiller

1996

Cell and Tissue Research

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“…32 A case of apparent acceleration of retinitis pigmentosa with blindness following cytotoxic chemotherapy for non-Hodgkin's lymphoma has been reported. 33 The involved patient probably had Usher's syndrome (congenital sensorineural deafness).…”

Section: Posterior Segment Side Effectsmentioning

confidence: 99%

Toxicidad ocular de la quimioterapia sistémica anticancerosa

Omoti

2006

Pharmacy pract. (Granada Ed. impr.)

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*The increased use of chemotherapeutic agents has resulted in longer cancer patient survival. Consequently the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Ocular toxicity induced by cancer chemotherapy includes a broad spectrum of disorders, reflecting the unique anatomical, physiological and biochemical features of the eye. Understanding the ocular side effects will assist the ophthalmologist and oncologist to recognize them early and intervene before blindness occurs. Anticipation of various treatmentrelated toxicities may also provide the opportunity for pharmacists to develop intervention strategies that could minimize or eliminate an expected side effect. The ophthalmologist should examine patients on anticancer therapy at baseline and three monthly thereafter. The various ocular side effects of anticancer chemotherapeutic agents, tamoxifen, and interferon on the adnexia, anterior segment, posterior segment and neuro-ophthalmic structures were reviewed.

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“…Second is the possibility that RP may also have been a consequence of chemotherapy, even though we consider this explanation highly unlikely. We are not aware of any chemotherapeutical agents proven to be associated with the development of RP, there is only one case study reporting acceleration of RP after chemotherapy in a patient with non-Hodgkin’s lymphoma [ 15 ]. As we have no previous ophthalmological documentation of the patient, it is not known whether RP existed prior to the chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Bilateral cystoid macular edema following docetaxel chemotherapy in a patient with retinitis pigmentosa: a case report

et al. 2015

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BackgroundDocetaxel is a chemotherapeutic agent of the taxane class of drugs for the treatment of breast cancer. We present a female patient who noted decreased vision after docetaxel treatment.Case presentationA 45-year-old female patient received docetaxel treatment after resection of a breast carcinoma. Funduscopy and optical coherence tomography (OCT) showed cystoid macular edema on both eyes. Dilated funduscopy also showed bone spicule-like pigmented deposits, typical for retinitis pigmentosa. Besides the fundus appearance restricted peripheral vision and scotopic electroretinogram confirmed the diagnosis of retinitis pigmentosa. Chemotherapy was discontinued following a consulation with the oncologist of the patient. After five weeks, visual acuity improved significantly along with decrease of retinal thickness measured by OCT.ConclusionDocetaxel may cause ocular adverse effects such as cystoid macular edema. Ophthalmological examination is warranted for patients with visual complaints during docetaxel chemotherapy.

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Case Report: Retinitis Pigmentosa Following Cytotoxic Chemotherapy in Usher’s Syndrome

Cited by 8 publications

References 13 publications

Renewal of the ciliary axoneme in cone outer segments of the retina of Xenopus laevis

Renewal of the ciliary axoneme in cone outer segments of the retina of Xenopus laevis

Toxicidad ocular de la quimioterapia sistémica anticancerosa

Bilateral cystoid macular edema following docetaxel chemotherapy in a patient with retinitis pigmentosa: a case report

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