Case report: Primary malignant melanoma of the uterine cervix

Owens, Owen; Pollard, K.; Khoury, Georgette; Dyson, J. E.; Jarvis, G. J.; Joslin, C. A.

doi:10.1016/s0009-9260(88)80565-8

Cited by 15 publications

(12 citation statements)

References 11 publications

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“…Three hypothesis have been proposed to try to understand the origin of melanocytes in the cervix: (a) melanocytic cells originating from Schwannian cells, (b) melanocyte migration from the neural crest, and (c) melanocytic differentiation from the epithelium of the endocervix wall [19, 20]. The most prevailing theory to explain the origin of blue nevi is that they arise from latent dendritic melanocytes from the embryologic migration of melanocytes from the neural crest [21].…”

Section: Discussionmentioning

confidence: 99%

Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination

Parada

Peña

Riu

2012

Case Reports in Pathology

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Malignant melanoma (MM) and blue nevi of the uterine cervix are an extremely rare neoplasm, probably derived from embryologic migration of melanocytes from the neural crest. MM displays aggressive behavior with a poor prognosis. We report the case of a 76-year-old postmenopausal woman abnormal vaginal bleeding. She underwent a hysterectomy and bilateral salpingo-oophorectomy with paraaortic-iliac lymphadenectomy. Histopathological and immunohistochemical studies were consistent with the diagnosis of MM and blue nevi in the uterine cervix. Although it is extremely rare, this case suggests that MM of the uterine cervix should be considered in the differential diagnosis of undifferentiated neoplasm. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.

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Section: Discussionmentioning

confidence: 99%

Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination

Parada

Peña

Riu

2012

Case Reports in Pathology

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“…in regional lymph nodes) are all demon strated [38]. Moreover, junctional change is not evi denced in many cases because superficial ulceration is a common finding [14,[24][25][26], Histochemical (FontanaMasson silver stain) and immunohistochemical (Vimentin, S-100 protein, HMB-45 antibody), procedures con firm the initial diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma of the Uterine Cervix: Case Report and Review of the Literature

Pinedo¹,

Ingelmo²,

Miranda³

et al. 1991

Gynecol Obstet Invest

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“…[1][2][3] The cervix is a rare site for primary malignant melanoma. [1][2][3] The cervix is a rare site for primary malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…12,18 Histologically the lesion may be composed of spindle cells showing intracytoplasmic melanin, or nests of large cells with scanty eosinophilic cytoplasm and large hyperchromatic nuclei with prominent nucleoli, or large pleomorphic cells with abundant cytoplasm, large vesicular bizarre nuclei, and prominent abnormal mitoses. 1,5,6,8,[21][22][23] Junctional change was not found by Owens et al, 1 who reported a case based on circumstantial evidence suggesting malignant transformation of preexisting melanosis to melanoma in the absence of primary melanoma elsewhere. The stroma may be desmoplastic.…”

Section: Discussionmentioning

confidence: 99%

“…7,9 The basal cells of the cervical epithelium are replaced by cells with a clear cytoplasm, and resemble cells seen in extramammary Paget's disease. 1,27,31 These melanocytes may have migrated from the neural crest 31 or may be the result of local differentiation of preexisting cells. The cervix is not a common site for metastatic malignancies, because it has a limited blood supply and the cervical fibrous stroma provides a poor site for the growth of tumors.…”

Section: Discussionmentioning

confidence: 99%

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Primary malignant melanoma of the uterine cervix: Report of a case diagnosed by cervical scrape cytology and review of the literature

Deshpande

Munshi

2001

Diagnostic Cytopathology

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Cervical melanoma is a rare neoplasm and is seldom diagnosed by cervical scrape cytology. The possibility of metastatic melanoma should be excluded before making a diagnosis of primary cervical melanoma. We present a case of primary cervical melanoma diagnosed by cervical scrape cytology and a review of literature. The patient presented with vaginal bleeding of 3 mo duration and an ulcerated cervical growth. Cervical smear showed bizarre and abnormal cells containing pigment.

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Case report: Primary malignant melanoma of the uterine cervix

Cited by 15 publications

References 11 publications

Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination

Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination

Primary Malignant Melanoma of the Uterine Cervix: Case Report and Review of the Literature

Primary malignant melanoma of the uterine cervix: Report of a case diagnosed by cervical scrape cytology and review of the literature

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