Case report of renal pelvis squamous cell carcinoma with tumor embolus in autosomal dominant polycystic kidney disease

Abstract

Introduction:Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem hereditary disease characterized by formation of cysts in the ductal organs. Renal pelvis malignancy in ADPKD is very rare and sporadically reported in the previous literature. Here, we report the first case of renal pelvis squamous cell carcinoma with tumor embolus in a 35-year-old ADPKD patient. The patient presented with 3 months of persistent backache and intermittent fever, and was initially diagnosed as intracystic hemorrhage with inferior vena cava thrombosis formation. As a result, he received anticoagulation therapy in a local hospital. However, his backache got worsened during the therapy, and he lost 10 kg of his body weight from the onset of illness. In our hospital, computed tomography demonstrated a heterogeneous right renal mass as well as emboli in the inferior vena cava and bilateral renal veins. Positron emission tomography computed tomography and biopsy were also performed, but the results were equivocal. Considering the patient's willingness and the potential malignancy, we performed thoracoabdominal nephrectomy and embolectomy, and histological examination made the diagnosis of renal pelvis squamous cell carcinoma. After adjuvant chemotherapy including paclitaxel and carboplatin, the patient obtained improved physical status and was disease free at the 6-month follow-up. Although rare, renal pelvis squamous cell carcinoma should be considered in the differential diagnosis of renal mass in ADPKD patients.Conclusion:Our case suggested surgery combined with adjuvant chemotherapy might be effective treatments in such a condition.

Renal Squamous Cell Carcinoma-related Polymyositis in a Patient with Autosomal Dominant Polycystic Kidney Disease

“…Interestingly, renal pelvis squamous cell carcinoma remains rare among ADPKD patients, as squamous cell carcinoma does not occur in renal tissue without squamous metaplasia. The coexistence of renal pelvis SCC in ADPKD patient has only been described in one case report by Xie et al They reported a 35-year-old man with ADPKD who had the thrombosis formation of SCC in the inferior vena cava; however, in that case, no renal stone was observed ( 8 ). Patients with ADPKD are known to be more predisposed to stone formation than non-ADPKD patients ( 9 ).…”

Renal pyelocalyceal squamous cell carcinoma in a patient with an ectopic kidney presenting with chronic pyelonephritis: a case report

“…Xie et al . reported a case of renal pelvis SCC with tumor embolus in a 35-year-old patient with autosomal dominant polycystic kidney disease [5].…”

“…Early metastatic spread is common, and the prognosis is poor, with few patients surviving longer than 5 years. Until now, SCC cases have been reported in the kidneys with various anomalies such as horseshoe kidney, polycystic kidney disease, and renal calyceal diverticulum [3–5]. To our knowledge, this is the first reported case of SCC in a pelvic ectopic kidney.…”

Case report of primary renal pelvis squamous cell carcinoma coexisting with long-standing calculi in left kidney on 18F-FDG PET/CT

“…[7–9] In 1 case, an autosomal-dominant polycystic kidney disease patient of concurrent renal pelvis squamous cell carcinoma and tumor embolus was reported. 18 F-FDG PET/CT showed increased radioactivity uptake in the tumor emboli in the inferior vena cava, but not in the primary tumor.…”

“…18 F-FDG PET/CT showed increased radioactivity uptake in the tumor emboli in the inferior vena cava, but not in the primary tumor. [7] Recently, a case of primary kidney parenchyma SCC was introduced. PET/CT showed valid 18 F-FDG was taken up by cystic-solid mixed masses in the right kidney.…”