Case report of primary renal pelvis squamous cell carcinoma coexisting with long-standing calculi in left kidney on 18F-FDG PET/CT

Deng, Shengming; Zhang, Bin; Huang, Ying; Li, Jihui; Sang, Shibiao; Zhang, Wei

doi:10.1097/md.0000000000006341

Cited by 6 publications

(5 citation statements)

References 9 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent MRI led to the diagnosis of a malignant mass. MRI and 18 F-fluorodeoxyglucose positron emission tomography (PET)/CT may be a useful diagnostic tool to evaluate primary renal pelvic SCC [ 11 ]. More radiological examinations are suggested for a suspected renal mass, especially in patients with hydronephrosis, chronic pyelonephritis, stones, and/or renal anomalies.…”

Section: Discussionmentioning

confidence: 99%

“…More radiological examinations are suggested for a suspected renal mass, especially in patients with hydronephrosis, chronic pyelonephritis, stones, and/or renal anomalies. As mentioned above, PET/CT is usually a reliable radiological examination for such soft masses [ 11 ]. Percutaneous biopsy also contributes to the diagnosis of renal SCC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report

Sun

2020

J Med Case Reports

View full text Add to dashboard Cite

Introduction Squamous cell carcinoma of the renal pelvis is a rare neoplasm, accounting for less than 0.8% of malignant renal tumors. Chronic irritation is believed to be the primary pathogenic cause for squamous cell carcinoma of the renal pelvis. The most frequently reported cases of squamous cell carcinoma of the renal pelvis generally present with hydronephrosis, pyelonephritis, or nephrolithiasis. The skin of the flank is a very uncommon site of clinical presentation. Here, we report an exceedingly rare case of squamous cell carcinoma of the renal pelvis presenting as skin invasion of the flank. Case presentation A 66-year-old Han Chinese man consulted our hospital because of a right lumbar skin lesion lasting more than 3 months. His physical examination revealed that he had a palpable mass about 6.0 cm × 5.0 cm in size at the posterior axillary line in the right low back with skin ulceration 3 mm in diameter and exudation on it. Magnetic resonance imaging showed hydronephrosis of the right kidney and plaque-like abnormal signal in the middle portion of the kidney. The patient underwent a right nephrectomy. The sinus tract formation between the ulcerative skin in the right low back and the middle portion of the right kidney could be found. The distended kidney could not be excised entirely for tight adhesion. Pathological examination showed moderately differentiated renal squamous cell carcinoma with invasion of the renal parenchyma and perirenal adipose tissue. Conclusion It is extremely rare for renal squamous cell carcinoma to present as skin invasion. Recurrent percutaneous nephrolithotomy may be a risk factor for squamous cell carcinoma of the renal pelvis. The possibility of renal squamous cell carcinoma should be kept in mind in patients who have hydronephrosis, nephrolithiasis, or chronic pyelonephritis for a long time or with renal anomalies. More radiological examinations are suggested for such patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report

Sun

2020

J Med Case Reports

View full text Add to dashboard Cite

show abstract

“…SCCs of the kidney are frequently associated with renal stones, hydronephrosis and chronic infection, all of which contribute to chronic irritation and subsequent development of squamous metaplasia in the neighboring epithelium 5 . Renal SCC usually presents at an advanced stage with extensive local infiltration and has a poor prognosis 6 . Primary SCC has a slight female preponderance occurring most commonly in the age group of 50-70 years 7 .…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Kidney in a Patient of Renal Calculi: Rare and Aggressive Variant of Renal Cancer

Hasan

Zehra

Parween

et al. 2020

Ann Jinnah Sindh Med Uni

View full text Add to dashboard Cite

Squamous Cell Carcinoma (SCC) of kidney is a rare presentation. It behaves aggressively in case of kidney. It is usually diagnosed at an advance stage and has a poor prognosis. Renal squamous cell carcinoma is usually associated with stones. Chronic irritation due to stone causes metaplasia of lining epithelium resulting in transformation of squamous cell carcinoma which is rare but the most fatal complication. Here we are presenting a case of renal squamous cell carcinoma associated with stones.

show abstract

“…SCC of urothelial tract is thought to arise through a process of squamous metaplasia of urothelium (7). It may be triggered by chronic irritation and infection such as polycystic kidney disease (7), prolonged use of immunosuppressants (8,9), chronic inflammation (10)(11)(12)(13)(14)(15)(16)(17)(18), kidney stones (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), and horseshoe kidney (25,(30)(31)(32)(33)(34). Early symptoms are atypical including recurrent urinary infections, ongoing pyuria, hematuria or backache.…”

Section: Introductionmentioning

confidence: 99%

A case report of complete pathological remission after chemotherapy in a patient with primary renal squamous cell carcinoma

Yu¹,

Lan²,

Li³

et al. 2021

Transl Androl Urol

View full text Add to dashboard Cite

This is the first case report of the outcomes of systemic chemotherapy in a patient with locally advanced renal squamous cell carcinoma, a rare tumor, as well as the first next generation sequencing study of this rare tumor. The patient's main symptoms were fever and low back pain. Initial positron emission tomography and computed tomography (PET-CT) suggested a malignant renal tumor at onset, but biopsy confirmed renal squamous cell carcinoma. Next generation sequencing showed a low level of microsatellite instability (MSI-L), a high tumor mutational burden (TMB-H), a high neoantigen burden (TNB-H), and a strong loss of heterozygosity (LOH) for human leukocyte antigen (HLA), with 67 deleterious mutations.The patient achieved partial radiological remission after a cycle of systemic chemotherapy with albuminbound paclitaxel combined with nedaplatin. After radical resection of the left renal tumor, postoperative pathology confirmed complete tumor remission and tumor-like xanthogranulomatous pyelonephritis.Conclusion: This renal squamous cell carcinoma patient responded to systemic chemotherapy with paclitaxel combined with platinum, providing a reference for the future treatment of similar cases. Pathology and gene sequencing indicated that renal squamous cell carcinoma occurred in a background of active inflammation and that the tumor evolved immune escape mechanisms such as loss of HLA heterozygosity, with gene repair defects and TMB-H.

show abstract

Case report of primary renal pelvis squamous cell carcinoma coexisting with long-standing calculi in left kidney on 18F-FDG PET/CT

Cited by 6 publications

References 9 publications

Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report

Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report

Squamous Cell Carcinoma Kidney in a Patient of Renal Calculi: Rare and Aggressive Variant of Renal Cancer

A case report of complete pathological remission after chemotherapy in a patient with primary renal squamous cell carcinoma

Contact Info

Product

Resources

About