Case Report of Refractory Psoriatic Arthritis Achieving Remission Using <i>Nigella sativa</i> (Black Seed Oil) Extract

Rida, Mohamad Ali; Gladman, Dafna D.

doi:10.3899/jrheum.191292

Cited by 3 publications

(1 citation statement)

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“…Extract from N. sativa has been found to have antiproliferative, antiosteoporotic, effects in many studies. The major active ingredient, thymoquinone, has been demonstrated to have comparable results with topical hydrocortisone 2.5% when applied topically on carrageenaninduced paw edema, manifested by a notable decrease in leukocyte count and tumor necrosis factor-α concentration in inflamed area (Rida and Gladman 2020). Brain pathology associated with Parkinson disease: TQ extracted from N. sativa protects against alpha synuclein (αSN)-induced synapse damage, impairment observed in the brains of patients with Parkinson's disease and dementia with Lewy bodies (Alhebshi et al 2014).…”

Section: Traditional Disease Prevention and Controlmentioning

confidence: 99%

Thymoquinone: Biosynthesis, Biological Activities and Therapeutic Potential from Natural and Synthetic Sources

Aftab¹

2021

IJAB

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Thymoquinone (TQ; 2-isopropyl-5-methyl-1,4-benzoquinone) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L. and Satureja montana L. It is found in crystalline triclinic form in a range of organs in these plants. TQ has been synthetically prepared from thymol (2-isopropyl-5-methylphenol); commercially it is synthesized by modification of thymol and carvacrol (5-isopropyl-2-methylphenol). TQ has substantial therapeutic potential because of its anti-cancer, hepato-protective, anti-inflammatory, antioxidant, antimicrobial and cardio-protective activities in cell culture systems and animal models. In this article, we have reviewed recent studies on the natural and synthetic sources of TQ, its biosynthetic pathway and its modes of action in human and experimental models, as well as its commercial preparation. We also compiled the medicinal effects of TQ. The biological activities of TQ support the potential of this plant secondary metabolite as a drug with a wide range of therapeutic applications. To substantiate the benefits and pharmaceutical properties of TQ, further well-designed clinical research is required. © 2021 Friends Science Publishers

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Section: Traditional Disease Prevention and Controlmentioning

confidence: 99%