Case Report of Idiopathic Pulmonary Haemosiderosis in a Child with recurrent chest infections

Ibrahem, Renan E.; Arasaretnam, Anita; Ordidge, Katherine; Vedelago, John; Toy, Rosemary

doi:10.3941/jrcr.v5i9.669

Cited by 6 publications

(12 citation statements)

References 9 publications

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“…IPH is a rare disease with the incidence of 0.24-1.23 cases per million in selected population [2,[13][14][15]. IPH is life threatening condition and the early diagnosis is essential for early treatment in order to improve the prognosis and to avoid complications of recurrent alveolar hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Successful Liposteroid Therapy for a Recurrent Idiopathic Pulmonary Hemosiderosis with Down Syndrome

Tobai

Yano

Sato

et al. 2020

Case Reports in Pediatrics

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Idiopathic pulmonary hemosiderosis (IPH) is a rare and life-threatening disorder. Early diagnosis and appropriate management are essential for their better prognosis and patients’ quality of life (QOL). It is considered that Down syndrome patients with IPH have a worse prognosis compared to other IPH cases. A 2-year-old girl with Down syndrome received the diagnosis of IPH after two episodes of massive pulmonary hemorrhage requiring assist ventilation, who suffered from recurrent IPH during tapering period of oral corticosteroid, started liposteroid therapy. We report here a case of successful control of recurrent IPH and improved QOL enormously with tapering dose of corticosteroid after starting liposteroid therapy.

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Section: Discussionmentioning

confidence: 99%

Successful Liposteroid Therapy for a Recurrent Idiopathic Pulmonary Hemosiderosis with Down Syndrome

Tobai

Yano

Sato

et al. 2020

Case Reports in Pediatrics

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“…Çocukluk döneminde cinsiyet farkı görülmez. Erişkin dönemde erkeklerde daha sık görülür (6). İPH genellikle on yaş altında, yaygın olarak da 1-7 yaşta görülür (3).…”

Section: Discussionunclassified

“…gibi nedenlerin dışlanması ile konur (3,5,6). İPH bazı olgularda çölyak hastalığı ile ilişkili bulunmuştur (5,6).…”

Section: Discussionunclassified

A Rare Cause of Hemoptysis in a 16-Year-Old Patient: Idiopathic Pulmonary Hemosiderosis

Şimşek¹,

Ekşioğlu²,

Cinel³

et al. 2014

Turkish J Pediatr Dis

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Hemoptizi; trakeobronşiyal ağaç ya da akciğer parankiminden kaynaklanan kanamanın ekspektorasyonudur. Balgamda çizgi şeklinde kan görülmesinden masif hemoptizi olarak isimlendirilen ve çoğunlukla ölümcül olabilen kanamaya kadar değişebilmektedir. Nedenleri; sistemik hastalıklar (Goodpasture Sendromu, Wegener granülomatozisi, sistemik lupus eritematozus), kardiyak (mitral stenoz, triküspit endokarditi), pulmoner (bronşektazi, pulmoner emboli, kistik fibrozis) neoplastik (bronşiyal adenom, bronkojenik karsinom, metastatik tümör) travmatik (künt ya da penetre göğüs travması), enfeksiyöz (akciğer apsesi, tüberküloz), vasküler (pulmoner hipertansiyon, A-V malformasyon, aort anevrizması), hematolojik (Dissemine intravaskuler koagülasyon, trombositopeni) hastalıklar olabileceği gibi ilaç (aspirin, kokain) ya da toksik nedenlerle ve iyatrojenik (bronkoskopi, transtrakeal aspirasyon) de olabilir (1). ÖZETHemoptizi; trakeobronşiyal ağaç ya da akciğer parankiminden kaynaklanan kanamanın ekspektorasyonudur. Kardiak, pulmoner, hematolojik, enfeksiyoz nedenler, bazı sistemik hastalıklar ve idiyopatik pulmoner hemosideroz hemoptiziye yol açabilir. İdiyopatik pulmoner hemosiderozis; akciğerlerde anormal hemosiderin depolanmasıyla giden, difüz alveolar hemorajiye bağlı hemoptizi yapan nadir bir pulmoner hastalıktır. İdiyopatik pulmoner hemosiderozis genellikle on yaş altında, yaygın olarak da 1-7 yaşta görülür. Çocukluk çağında cinsiyet dağılımı eşit iken, erişkin dönemde erkeklerde daha sık görülmektedir. Tanısı fiberoptik bronkoskopi ile alınan bronkoalveoler lavaj sıvısında hemosiderin yüklü makrofajların görülmesiyle ve intrapulmoner, ekstrapulmoner kanama yapabilen nedenler ekarte edilerek konulur.Burada, hemoptizi ile gelen ve İdiyopatik pulmoner hemosiderozis tanısı alan kız olguyu, hastalığın nadir görülmesi nedeniyle tekrar hatırlatmak ve ilk kez adölesan dönemde bulgu vermesini vurgulamak amacıyla sunduk. Çocukluk ve adelosan dönemde solunumsal semptomlar, özellikle de hemoptizi ile başvuran; göğüs görüntülemede yamalı, yaygın buzlu cam görünümü saptanan olgularda, ayırıcı tanıda İdiyopatik pulmoner hemosiderozis yer almalıdır.

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“…Long-term IPH may lead to interstitial fibrosis. By definition, IPH does not present renal involvement, immune complexes, and antineutrophil cytoplasmic antibody (ANCAS) (1,3,4,8,10,11,17,18,21) . IPH diagnosis is made on the basis of clinical, radiologic, laboratorial and histopathological findings.…”

Section: Discussionmentioning

confidence: 99%

“…The patients present recurrent episodes of pulmonary hemorrhage, which may occasionally determine ventilatory restriction. The clinical presentation is extremely variable, and the most common symptoms include iron deficiency anemia, diffuse pulmonary infiltrates, and hemoptysis (3,8,10,11,25) .…”

mentioning

confidence: 99%

Idiopathic pulmonary hemorrhage: morphology and differential diagnosis. Case report

Cambruzzi¹,

Pêgas²,

Vedana³

2013

J. Bras. Patol. Med. Lab.

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Idiopathic pulmonary hemorrhage (IPH) is a rare cause of alveolar hemorrhage (AH) with unknown etiology that primarily affects children. The process has a variable clinical progression, and its diagnosis is established after excluding all causes of AH. Herein, the authors report a case of IPH in an adult male patient referring cough and hemoptysis. The conventional radiography computed tomography imaging identified zones of consolidation and areas of ground-glass attenuation in the lower lobes and lingula. Forced spirometry, bronchoscopy, and laboratorial tests yielded normal results. Several alveolar hemosiderin-laden macrophages were identified on bronchoalveolar lavage and lung biopsy. Thus, the histopathological findings associated with clinical data were compatible with IPH.

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Case Report of Idiopathic Pulmonary Haemosiderosis in a Child with recurrent chest infections

Cited by 6 publications

References 9 publications

Successful Liposteroid Therapy for a Recurrent Idiopathic Pulmonary Hemosiderosis with Down Syndrome

Successful Liposteroid Therapy for a Recurrent Idiopathic Pulmonary Hemosiderosis with Down Syndrome

A Rare Cause of Hemoptysis in a 16-Year-Old Patient: Idiopathic Pulmonary Hemosiderosis

Idiopathic pulmonary hemorrhage: morphology and differential diagnosis. Case report

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