Case report of diffusely metastatic rectal GIST

Puckett, Yana; Aryaie, Amir

doi:10.1016/j.ijscr.2017.05.033

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Rectal GISTs account for approximately 2% of all gist tumors and 0.1% of all colorectal tumors [1] . The majority of GISTs have a benign course, in some rare cases, it can exhibit an aggressive course, such as the case in our patient.…”

Section: Discussionmentioning

confidence: 99%

Metastatic rectal gastrointestinal stromal tumor with intestinal obstruction: A rare case report

Kassimi

Amal

Guerroum

et al. 2022

Radiology Case Reports

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Gastrointestinal stromal tumors (GISTs) arising from the rectum are rare. We report the case of an aggressive rectal gastrointestinal stromal tumor (GIST) in a 60-year-old female that presented for symptoms of constipation and lower gastrointestinal bleeding. Upon rectal examination, a hard mass was found at 6cm from the anal marge. An MRI was indicated that shows a well-demarcated lesion originates from the distal rectum with exophytic growth and central necrosis. The diagnosis of rectal gist was confirmed by colonoscopy with biopsy and immunohistochemical analyses of bioptic material. Liver metastases were seen on computerized tomography (CT). She was referred for palliative chemotherapy. The patient had suffered from intestinal obstruction three weeks after his initial presentation and passed away shortly thereafter. We aimed to report this case as an aggressive and rare GIST localization.

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Section: Discussionmentioning

confidence: 99%

Metastatic rectal gastrointestinal stromal tumor with intestinal obstruction: A rare case report

Kassimi

Amal

Guerroum

et al. 2022

Radiology Case Reports

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“…4,21 Puckett et al reported a rectal GIST with diffuse liver metastases. 23 The case revealed multiple lesions in the liver.…”

Section: Discussionmentioning

confidence: 95%

Diagnostic challenges of gastrointestinal stromal tumour during transurethral resection of the prostate: A case report

Putriyuni,

Zulfiqar,

Saberko

et al. 2023

JKKI

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Mesenchymal prostate tumours are relatively rare compared to epithelial tumours. To diagnose mesenchymal tumours on transurethral resection of the prostate (TURP) specimen, doctors have to consider a few differential diagnoses, including gastrointestinal stromal tumour (GISTs). We reported a 63 years-old male patient, presented with urinary retention in one week. Based on an initial scan of the abdomen, a large lobulated mass in the pelvic cavity from the prostate pushed up the urinary bladder. Histopathologic examination demonstrated cellular spindle cell neoplastic proliferation, a moderate degree of atypia, and a mitotic count of >5 per 50 high-power fields (HPFs) with a fascicular growth pattern. Immunohistochemically, the tumour had positive expression for CD117 (c-KIT), CD34, and discovered on Gist-1 (DOG-1), while smooth muscle actin (SMA) and S-100 were negative. The pathological report was consistent with a high-risk group of GISTs in the prostate. Subsequent imaging revealed that the tumour mass was centrally located between the rectum and prostate, infiltrating bladder and liver metastases. Comprehensive differential diagnoses of mesenchymal tumours involving the prostate are necessary because of the inadequacy of specific clinical signs, symptoms, and unexpected location. Diagnoses of GISTs was performed based on spindle cell pattern and the positive immunohistochemistry expression for CD117, CD34, and DOG-1. The tumour mass involved in the prostate with spindled morphology should be considered as a GIST, assisted with appropriate immunohistochemistry marker panel. It is a challenge to diagnose the GIST particularly involving the prostate.

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“…Local tumour resection (LTR) or sphincter-preserving procedures can be performed for small or low-grade tumours [ 26 ]. Different conservative approaches such as transsacral (Kraske) for posterior low-rectal GIST and transvaginal or transperineal approach in women with smaller tumours on the anterior rectal wall have been described [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Low anterior resection or an abdominoperineal resection are still indicated for rectal tumours located below 5 cm from the anal verge with a high risk of positive CRM [ 28 ]. Some authors always recommended both surgical approaches depending on the tumour size (>2 cm) and the distance from the dentate line [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumour of the rectum and intestinal obstruction: case report

Rivera¹,

Jabiles²,

Passiuri³

et al. 2020

ecancer

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We report the case of a 75-year-old female patient with a big tumour in the lower rectum with intestinal obstruction and lower gastrointestinal bleeding history who underwent a tumour biopsy under laparotomy and end colostomy at another hospital in Peru. She came to our institution for clinical evaluation with a pathology result of a rectal gastrointestinal stromal tumour. An extra elevator abdominoperineal resection was performed with tumour-free margins. The histology confirmed a high-grade (G2) rectal gastrointestinal stromal tumour with a mitotic index of 27/50. DOC-1 (+) and CD117 (+) in immunohistochemistry. Genomic DNA was extracted from the paraffin-fixed tumour sample, and c.1504_1509dupGCCTAT (p.Ala502_Tyr503dup) mutation was detected in exon 9 of the KIT gene. Imatinib 400 mg per day for 3 years was indicated as adjuvant treatment. Currently, she has a disease-free survival of 12 months.

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Case report of diffusely metastatic rectal GIST

Cited by 3 publications

References 11 publications

Metastatic rectal gastrointestinal stromal tumor with intestinal obstruction: A rare case report

Metastatic rectal gastrointestinal stromal tumor with intestinal obstruction: A rare case report

Diagnostic challenges of gastrointestinal stromal tumour during transurethral resection of the prostate: A case report

Gastrointestinal stromal tumour of the rectum and intestinal obstruction: case report

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