Case Report: Multivisceral Transplantation for an Extensive Cystic Lymphangioma of the Mesenteric Root

Moulin, L.; Rumbo, Carolina; Romero, P.; Pedraza, N.; Hervá, D. Garcia; Orce, Guillermo; Trentadue, Julio; Ramisch, Diego; Gondolesi, Gabriel

doi:10.1016/j.transproceed.2015.12.067

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…Reports of multivisceral transplantation in the treatment of children with unresectable abdominal tumors are limited. Of the original 11 articles included in our literature review, four specifically chronicled outcomes of pediatric patients . Review of these reports identified six patients, three males and three females, with a median age of 6 years (range 5 months to 14 years).…”

Section: Literature Reviewmentioning

confidence: 99%

Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature

Lee

Hodgkinson

Fawaz

et al. 2017

Pediatric Transplantation

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Standard management of intra-abdominal pediatric solid tumors requires complete resection. However, tumors with multiple organ and vascular involvement present a unique surgical challenge. We conducted a retrospective chart review of four patients, aged 2-14 years, undergoing MVT for intra-abdominal tumors with significant involvement of the visceral arteries and/or portomesenteric venous system at our institution. Indications for MVT included hepatocellular carcinoma, inflammatory myofibroblastic tumor, and two cases of hepatoblastoma. Grafts included liver, stomach, small bowel, and pancreas in all patients, with two patients also receiving spleens, and one, a partial esophageal transplant. Median hospital stay was 80 days. Postoperative complications included reoperation for abdominal hematoma and bowel obstruction, steroid responsive intestinal rejection, wound dehiscence, fungemia, seizures, and chyle leak with pleural effusion. One patient developed Epstein-Barr virus-associated complications which responded well to treatment. On follow-up (range 2.8-7.8 years), all patients have satisfactory graft function and no evidence of recurrent disease. MVT is an effective means of achieving complete gross resection of intra-abdominal malignancies in patients with multiple organ and vascular involvement.

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Section: Literature Reviewmentioning

confidence: 99%

Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature

Lee

Hodgkinson

Fawaz

et al. 2017

Pediatric Transplantation

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“…The patient ultimately succumbed to a systemic infection three months postoperatively. 2 By contrast, another case report noted antenatal discovery of two mesenteric root CLs. They reported that the masses spontaneously resolved on follow up imaging within one to two years.…”

mentioning

confidence: 95%

“…1 Only 1 per cent of CLs are located around the mesenteric root. 2 One case report involved an unresectable mesenteric root lymphangioma, which ultimately required a multivisceral transplantation. The patient ultimately succumbed to a systemic infection three months postoperatively.…”

mentioning

confidence: 99%

Cystic Lymphangioma of the Mesenteric Root in an Adolescent, an Operative Challenge

Muncie

Morris

Blewett

2017

The American Surgeon

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“…It may also be the sequelae of non-occlusive processes as is found in conditions causing low mesenteric blood flow like cardiac insufficiency and sepsis [3], [4]. However, important features of acute mesenteric ischaemia include bacterial translocation, systemic inflammatory response syndrome and reperfusion injury [5].…”

Section: Introductionmentioning

confidence: 99%

Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling

Omóbòwálé

Oyagbemi

Adejumobi

et al. 2016

Journal of Ayurveda and Integrative Medicine

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BackgroundAzadirachta indica is widely distributed in Africa, Asia and other tropical parts of the world. A. indica (AI) is traditionally used for the treatment of several conditions including cancer, hypertension, heart diseases and skin disorders. Intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction syndrome and death.ObjectiveIn this study, we investigated the ameliorative effects of AI on intestinal ischaemia-reperfusion injury-induced cardiorenal dysfunction.Materials and methodsSixty rats were divided into 6 groups; each containing 10. Corn oil was orally administered to group A (control) rats for 7 days without intestinal ischaemia-reperfusion injury. Group B underwent intestinal ischaemia-reperfusion injury (IIRI) without any pre-treatment. Groups C, D, E and F were pre-treated orally for 7 days with 100 mg/kg AI (100 and (200 mg/kg) vitamin C (100 and 200 mg/kg) respectively and thereafter underwent IIRI on the 8th day.ResultsThe cardiac and renal hydrogen peroxide increased significantly whereas serum xanthine oxidase and myeloperoxidase levels were significantly elevated (p < 0.05) in IIRI only when compared to the control. The cardiac and renal reduced glutathione, glutathione peroxidase, protein thiol, non-protein thiol and serum nitric oxide (NO) decreased (p < 0.05) significantly following IIRI. Immunohistochemical evaluation of cardiac and renal tissues showed reduced expressions of the extracellular signal regulated kinase (ERK1/2) in rats with IIRI only. However, pre-treatment with A. indica and vitamin C significantly reduced markers of oxidative stress and inflammation together with improvement in antioxidant status. Also, reduced serum NO level was normalised in rats pre-treated with A. indica and vitamin C with concomitant higher expressions of cardiac and renal ERK1/2.ConclusionsTogether, A. indica and vitamin C prevented IRI-induced cardiorenal dysfunction via reduction in oxidative stress, improvement in antioxidant defence system and increase in the ERK1/2 expressions. Therefore, A. indica can be a useful chemopreventive agent in the prevention and treatment of conditions associated with intestinal ischaemia-reperfusion injury.

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Case Report: Multivisceral Transplantation for an Extensive Cystic Lymphangioma of the Mesenteric Root

Cited by 9 publications

References 6 publications

Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature

Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature

Cystic Lymphangioma of the Mesenteric Root in an Adolescent, an Operative Challenge

Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling

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