Case report: first report of a prosthetic joint infection caused by Facklamia hominis

Corona, Pablo S.; Haddad, Sleiman; Andrés, J.R. Fortuño; González-López, Juan José; Amat, Carles; Flores, Xavier

doi:10.1016/j.diagmicrobio.2014.08.008

Cited by 14 publications

(16 citation statements)

References 19 publications

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“…have been isolated from human clinical specimens with the exception of F. tabacinasalis and F. miroungae , which were isolated from tobacco powder and from an elephant seal nasal swab, respectively (Corona et al. 2014 ). Our data first show that Facklamia ignava exists in the gut of rodents.…”

Section: Discussionmentioning

confidence: 99%

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Wang

Guan

Zhao

et al. 2018

Pharmaceutical Biology

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Context: Alcoholic liver fibrosis (ALF) is treatable and reversible consequence of liver disease. Intestinal microflora plays an important role in the progression of liver disease. Garlic (Allium sativum L. [Amaryllidaceae]) has been consumed as a traditional medicine to treat liver injury.Objective: To investigate the effects of garlic polysaccharide (GP) on ALF and intestinal microflora in mice.Materials and methods: KM mice were orally administered with alcohol (56%, 6 mL/kg) for 30 d to establish ALF model, and divided into four groups together with control group (water only). Hugan tablet (60 mg/kg) or GP (250 and 150 mg/kg) were given 5 h after each dose of alcohol. Biochemical markers in serum and liver homogenate were determined with kits. Alteration of intestinal microflora, and protein expressions of TGF-β1, TNF-α and decorin were detected.Results: In GP-H group, ALT and AST decreased to 18.85 ± 4.71 U/L and 40.84 ± 7.89 U/L. MDA, TC, TG and LDL-C decreased to 2.32 ± 0.86 mmol/mg, 0.21 ± 0.12 mmol/L, 0.96 ± 0.31 mmol/L and 0.084 ± 0.027 mmol/L. SOD, GSH-Px and GSH increased to 118.32 ± 16.32 U/mg, 523.72 ± 64.20 U/mg and 0.56 ± 0.05 mg/g. Ratios of TGF-β1 and TNF-α decreased to 0.608 ± 0.170 and 1.057 ± 0.058, decorin increased to 2.182 ± 0.129. Lachnospiraceae and Lactobacillus increased, Facklamia and Firmicutes decreased with GP pretreatment.Discussion and conclusions: Intestinal microflora provides novel insight into the mechanisms of GP that may be used to treat ALF and intestinal microflora dysbiosis.

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Section: Discussionmentioning

confidence: 99%

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Wang

Guan

Zhao

et al. 2018

Pharmaceutical Biology

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“…ignava, and F. languida), of which F. hominis appears the most common (4, 6, 8). Here, Facklamia hominis was isolated from the urinary tract of a 75-year-old male who presented to the emergency department (ED) with fever and hematuria and was admitted for sepsis.…”

Section: Announcementmentioning

confidence: 99%

Genome Sequence of a Facklamia hominis Isolate from a Patient with Urosepsis

Mostafa

Taffner

Wang

et al. 2019

Microbiol Resour Announc

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“…Importantly, our study has identified some bacteria genera not previously isolated from ticks,including Facklamia,Vagococcus,Ruminococcus,Lachnospira,Bradyrhizobium,Peptostreptococcus,Jeotgalicoccus,Roseburia,Brachybacterium,Sporosarcina,u114, Megamonas and Dechloromonas. Facklamia species have previously been isolated from various human clinical specimens (Collins et al, 1997;Corona et al, 2014;Healy, Beukenholt, Tuthill, & Ribeiro, 2005), and some diseases are believed to be caused by this species (LaClaire & Facklam, 2000). For example, F. hominis is now considered an emerging pathogen responsible for infective endocarditis and even fatal myocardial infarctions (Ananthakrishna et al, 2012;Safavi, Tufnell, & Bhalla, 2010).…”

Section: Profile Of Bacteria Distribution In Each Samplementioning

confidence: 99%

Tick saliva microbiomes isolated from engorged and partially fed adults of Haemaphysalis flava tick females

Cheng

2017

J Applied Entomology

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The tick Haemaphysalis flava is one of the most significant blood-feeding arthropod parasites and is a vector for numerous human and animal pathogens. However, a comprehensive investigation of the microbial communities found in the saliva of this tick species is lacking. This study used 16S rRNA Illumina sequencing to characterize the compositions of microbiomes present in saliva and whole tick samples isolated from engorged and partially fed adult H. flava females. This revealed that the bacterial diversity present in tick saliva increased after a prolonged blood meal, and that the species diversity found in saliva was significantly higher than that of whole ticks. Three bacteria phyla, in particular, made up more than 80% of the microbial community across all samples-Proteobacteria, Firmicutes and Actinobacteria. Furthermore, some of the genera identified in this study had not previously been reported in ticks before, such as Facklamia, Vagococcus, Ruminococcus, Lachnospira, Bradyrhizobium, Peptostreptococcus, Jeotgalicoccus, Roseburia, Brachybacterium, Sporosarcina, u114, Megamonas and Dechloromonas. Finally, we found that many of the isolated bacteria were opportunistic pathogens, indicating a potential risk to humans and livestock exposed to H. flava.These results will contribute to fully understanding the transmission of tick-borne pathogens. K E Y W O R D Sbacteria, Haemaphysalis flava, microbiome, saliva | INTRODUCTIONHaemaphysalis flava (Acari: Ixodidae) is a prevalent hard tick species found in many countries that feeds on a wide variety of hosts, including hares, dogs, cows, horses, wild boar, deer, bears, pigs, cattle, sheep, goats, hedgehogs, pandas, cats, squirrels and golden pheasants (He, Tang, & Cheng, 2016). As a vector for numerous pathogens, including encephalitis virus (Ko et al., 2010), Borrelia burgdorferi (Moon et al., 2013), Rickettsia (Someya, Ito, Maeda, & Ikenaga, 2015), Francisella tularensis (Kim et al., 2005), Bartonella (Ozawa et al., 1982), Anaplasma and Ehrlichia (Rar et al., 2010), H. flava has emerged as a significant threat to public health.Tick saliva plays a pivotal role in pathogen transmission (Nuttall & Labuda, 2004) and studying the microbes that inhabit it can contribute to both conventional disease discovery (in which a pathogen is discovered in a host and then identified in the tick population) and reverse discovery (in which a potential pathogen is characterized in ticks and then is subsequently shown to cause disease) (Tijsse-Klasen, Koopmans, & Sprong, 2014). However, information on the microbial populations present in tick saliva remains scarce. To date, the saliva microbiomes of Amblyomma maculatum (Budachetri et al., 2014) and Rhipicephalus microplus (Xiang, Poźniak, & Cheng, 2017) are the only two that have been surveyed. The microflora of saliva isolated from H. flava has been partially analysed using PCR-denaturing gradient gel electrophoresis (PCR-DGGE), but this system is unable to reveal in detail the microbial communities of saliva (He et al...

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Case report: first report of a prosthetic joint infection caused by Facklamia hominis

Cited by 14 publications

References 19 publications

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Genome Sequence of a Facklamia hominis Isolate from a Patient with Urosepsis

Tick saliva microbiomes isolated from engorged and partially fed adults of Haemaphysalis flava tick females

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