Case Report: Complex Treatment Using Vibroacoustic Therapy in a Patient With Co-Infection and COVID-19

Abstract

The present report highlights a case of successful treatment of a 59-year-old patient who experienced pain, swelling, hyperemia, the presence of a wound of the right knee joint, impaired function of the right lower limb, weakness, fatigue, and labored breathing. Sepsis was detected in the patient as a result of periprosthetic infection with concomitant severe COVID-19. The patient was admitted to the hospital for 59 days, with 57 days of treatment of the patient at the intensive care unit. A therapy of multiple organ failure involved complex treatment using antiviral and combined antibiotic therapy, taking into account the sensitivity of the pathogen to antibiotics; glucocorticoid therapy; anticoagulant therapy; the concept of non-invasive ventilation; and vibroacoustic pulmonary therapy as a method of physiotherapy as well. An integrated approach using a vibroacoustic device in the therapy of the patient with sepsis due to periprosthetic infection with concomitant coronavirus infection had a positive effect despite the lack of etiological treatment against the COVID-19.

Applying vibroacoustic therapy in the treatment of patients with COVID-associated pneumonia

“…Results. Against the background of complex therapy in combination with the course of VALT, patients in the study group showed a statistically significant decrease in the duration of hospitalization to 19 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) days, as opposed to 27 (24-34) days (p = 0.003) in the control group. When comparing the changes in the indicators of the surviving patients of the study group, a positive dynamics of the main indicators against the background of VALT was obtained: ∆VAS -2 (-3; -1), р = 0.000; ∆SpO2-6 (2; 7), р = 0.002; ∆PaO2-13 (2; 19), р= 0.001 in comparison with the dynamics of similar indicators of the control group.…”

“…Сравнение длительности госпитализации исследуемой группы и группы контроля показывает статистически значимое уменьшение показателя на фоне применения ВАЛТ (в исследуемой группе -19 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) дней, в группе контроля -27 (24-34) дней (p = 0,003)).…”

“…Сравнительный анализ продемонстрировал, что у выживших больных длительность госпитализации пациентов на фоне применения ВАЛТ статистически значимо меньше по сравнению с контрольной группой (в исследуемой группе -20 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) дней, в группе контроля -28,5 (24-34,3) дня (p = 0,008)) (рис. 1).…”

“…Также положительная динамика от лечения была отмечена по данным периферической оксиметрии, газовому составу крови, индексу оксигенации и рентгенографии органов грудной клетки в динамике. Проведение виброакустической терапии при комплексном лечении пациента способствовало более быстрой реабилитации и активизации, и, как следствие, продолжительность пребывания в отделении интенсивной терапии была значительно сокращена у больных, получавших ВАЛТ [18].…”

Non-Invasive Pulsatile Shear Stress Modifies Endothelial Activation; A Narrative Review

“…Sound-distributed stimulation to the endothelial cell matrix can trigger mechanosensors in cells affected by PSS and has been shown to increase eNO, can induce the expression of the mechanosensory protein Syndecan-4 (Syn4) and VEGF, as well as increase blood flow and clot dissolution [ 196 , 197 , 198 , 199 , 200 ]. This method may also be a plausible therapeutic strategy for MI [ 201 , 202 ] and sepsis [ 203 ].…”