Case report-baboon syndrome with paracetamol

Abstract

Adverse drug reaction (ADR) is defined as “any response to drug which is noxious or unintended and occurs at a dose normally used in man for prophylaxis, diagnosis or treatment of diseases or for modification of physiological function”. Among the ADRs reported, cutaneous drug reactions are most common. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), also known as baboon syndrome (BS), is included in the spectrum of systemically induced allergic contact dermatitis. Characteristics of SDRIFE include a sharply defined symmetric erythema in the gluteal area and in the flexural or intertriginous folds without any systemic symptoms or signs. We present a case of 30-year-old female with baboon syndrome after taking the combination of paracetamol and diclofenac. Awareness of SDRIFE (BS) as an unusual drug reaction is especially important since the connection between skin eruption and drug exposure may easily be overlooked or misdiagnosed.

Symmetrical drug-related intertriginous and flexural exanthema: a rare and unusual drug eruption

“…Betalactams are the most commonly described cause of SDRIFE, with many other medications reported 2. It is a type IV allergic reaction involving a T cell-mediated response 3. These are delayed reactions, typically occurring more than 12 hours following exposure to the allergen.…”