Case of linear porokeratosis: Successful treatment with topical 5% imiquimod cream

Ahn, Soojin; Lee, Hyunju; Chang, Sung‐Eun; Lee, Mi-Woo; Choi, Jee‐Ho; Moon, Kee‐Chan; Koh, Jai‐Kyoung

doi:10.1111/j.1346-8138.2006.00236.x

Cited by 19 publications

(13 citation statements)

References 5 publications

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“…Lineer PK'nın tedavi seçenekleri arasında ayrıca kriyoterapi, elektrodesikasyon, dermabrazyon, karbondioksid lazer, topikal 5-fluorourasil ve oral retinoidler bulunmaktadır 2 . Literatürde son zamanlarda tüm olgularda başarılı olmamakla birlikte diklofenak jel ve imikimod krem kullanımına dair bildiriler mevcuttur [3][4][5][6][7][8][9][10][11][12] . PK tedavisinde topikal diklofenak kullanımı çok nadir bildirilmiştir.…”

Section: Discussionunclassified

“…Bizim olgumuzda diklojenak jel tedavisi iyi tolere edilmiş olmasına rağmen kısmi yanıt alınmış ve tedavinin kesilmesini takiben nüks izlenmiştir. Literatürdeki olgu bildirilerinde porokeratozis Mibelli, lineer PK, dissemine süperfisyel aktinik PK ve dissemine palmoplantar PK gibi çeşitli klinik formlarda 6-12 hafta süreyle ve haftada 3-5 kez olmak üzere oklüzyonlu veya oklüzyonsuz uygulanan imikimod kremin değişik oranlardaki etkinliği gösterilmiştir [6][7][8][9][10][11][12] . Bir olguda bacaktaki porokeratozis Mibelli lezyonuna oklüzyonsuz olarak uygulanan topikal imikimod ile 5-fluorourasil tedavileri birlikte kullanıldıklarında etkili bulunmuştur 12 .…”

Section: Discussionunclassified

“…Bu tabloda çeşitli tedavi seçenekleri kullanılmış olmakla birlikte güncel tedavi yaklaşımlarından hiçbiri tamamen etkili bulunmamış ve uygulanması mümkünse en etkin tedavinin cerrahi eksizyon olduğu bildirilmiştir 1 . Literatürde son zamanlarda PK'lı olgularda diklofenak jel ve imikimod krem tedavilerinin kullanıldığı görülmektedir [3][4][5][6][7][8][9][10][11][12] . Burada diklofenak sodyum jel ve imikimod krem tedavisi uygulanmış olan penil lineer PK'lı bir olgu sunulmaktadır.…”

Section: Introductionunclassified

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A case of linear porokeratosis with penile localization

İlknur¹,

Akarsu

Pabuçcuoğlu

et al. 2014

TURKDERM

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Porokeratosis (PK), a disorder of epidermal keratinization with a unique clinical appearance, is characterized histopathologically by the presence of cornoid lamella. Many different clinical forms of PK have been described i.e., classical plaque-type PK of Mibelli, disseminated superficial actinic PK, linear PK, PK palmaris et plantaris disseminata, and punctate PK. Linear PK is a rare variant of PK presenting with slightly scaly atrophic papules following Blaschko's lines. Additionally, PK confined to the genital area is also an uncommon condition. Both genital and linear PK are extremely rare and only one case of genital linear PK has been reported in the literature. Here, we report the case of a patient with penile linear PK who was treated with diclofenac sodium gel and imiquimod cream but did not recover. (Turkderm 2014; 48: 160-2)

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Section: Discussionunclassified

Section: Introductionunclassified

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A case of linear porokeratosis with penile localization

İlknur¹,

Akarsu

Pabuçcuoğlu

et al. 2014

TURKDERM

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“…It also upregulates the transcription factor NF-Kb 6 . There have been previous reports of imiquimod showing its efficacy for treating some benign epidermal lesions such as linear porokeratosis and scrotal acanthoma 7,8 . Those authors proposed that the cytokines induced by imiquimod might be involved in the regression of these conditions.…”

Section: Discussionmentioning

confidence: 99%

Imiquimod as an Adjuvant Treatment Measure for Desmoplastic Trichoepithelioma

2011

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“…1 Linear porokeratosis is a rare clinical variant that usually arises in childhood. 10 At present, it is primarily used to treat actinic keratosis and superficial nonmelanoma cancers. Lesions may coalesce into larger plaques with central atrophy and a raised border along the lines of Blaschko.…”

Section: Commentmentioning

confidence: 99%

Linear Porokeratosis

García-Navarro

Baselga²,

Alomar

2009

Arch Dermatol

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Linear porokeratosis is a skin condition that usually shows a poor response to different modalities of treatment. We describe a patient successfully treated with 2 sessions of photodynamic therapy (PDT). REPORT OF A CASEA 13-year-old boy presented with a 4-year history of reddish-brown hyperkeratotic papules and plaques on the back of his lower leg. The lesions were arranged in a linear pattern and had a raised peripheral ridge and atrophic center (Figure 1). There was no nail dystrophy or other associated abnormalities. His mother had disseminated superficial actinic porokeratosis (DSAP) in the lower extremities. The patient's skin lesions were asymptomatic but cosmetically distressful. Findings from a histopathologic examination showed epidermal hyperplasia with a vertical column of tightly packed parakeratotic cells,

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Case of linear porokeratosis: Successful treatment with topical 5% imiquimod cream

Cited by 19 publications

References 5 publications

A case of linear porokeratosis with penile localization

A case of linear porokeratosis with penile localization

Imiquimod as an Adjuvant Treatment Measure for Desmoplastic Trichoepithelioma

Linear Porokeratosis

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