Case‐control study on prognostic factors in oral squamous cell carcinoma in young patients

Kaminagakura, Estela; Vartanian, José Guilherme; Silva, Sabrina Daniela da; Santos, Carlos Roberto dos; Kowalski, Luiz Paulo

doi:10.1002/hed.21347

Cited by 33 publications

(53 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for sample size, the number of participants ranged from 10 to 2,223 young subjects, as described in Table 1. Age distribution of patients varied: individuals considered young were those aged 18-39 years (7,8,10,11) (23.5%), < 30 years (13,20) (3,6,8,9,(11)(12)(13)(14)(16)(17)(18)(19)(20)(21) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the relationship with harmful habits, nine investigations demonstrated association between tobacco and/or alcohol use and OSCC, of which six presented positive association (7,10,11,16,18,19) . The other eight did not assess the parameter related to harmful habits ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Five of the 10 papers about the tumor-node-metastasis (TNM) Staging System indicated that a large amount of patients were diagnosed as T1 and/or T2 (8,(13)(14)(15)20) , being stages T3 and T4 (extensive tumors) predominant in other works (7,(10)(11)(12)18) .…”

Section: Resultsmentioning

confidence: 99%

“…Nonetheless, there are accounts in which such differences are not considered significant (10,11) . Recent studies have revealed similarities in OSCC rates of clinical evolution and survival of young and old patients (2,6) .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

The oral squamous cell carcinoma (OSCC) very often affects subjects above the sixth decade of life. However an increasing incidence has been observed in younger individuals, below 40 years. We conducted a systematized review of the current clinical, histopathological and therapeutic aspects of OSCC in young patients. Our work included studies that addressed OSCC involving young patients in the period 2007-2012, and which were indexed in PubMed. Initially, 499 articles were obtained; after refinement, 340 articles had their titles and abstracts evaluated, with 17 included in the sample. The majority of studies reported male predominance (87.5%), association with tobacco and/ or alcohol use (66.6%), advanced clinical stages at diagnosis (77.7%) and, at histopathology, moderately differentiated tumors (72.7%). Based on the results, we believe there are differences in the factors associated with pathogenesis, biological behavior and prognosis in young patients, since most studies show more rapid and aggressive tumor progression in this age group. We suggest the conduction of research focusing on the pathogenesis and carcinogenesis of OSCC in young patients, thereby searching for better scientific evidence.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

show abstract

“…The incidence rate of HNSCC has reached 0.4-3.6% in patients younger than 40 years which has drawn physicians' attention to the changing face of the disease (Llewellyn et al, 2001). On the other hand, recent studies have revealed differences of the risk factors and prognosis of HNSCC, in patients younger than 40 and the older patients, although controversy still exists regarding disease outcomes in young and old patients: some authors report a worse prognosis of the disease in the young compared to the old (Mallet et al, 2009;Kaminagakura et al, 2010;Soudry et al, 2010;Bachar et al, 2011;Kostrzewska-Poczekaj et al, 2012) while other studies have not found a significant clinical difference, or even a more favorable prognosis in younger patients (Luna-Ortiz et al, 2011). In fact, even if the tumors are histologically more mature and less malignant in younger patients compared to older ones, they are usually more advanced clinically at the time of diagnosis due to late referral of young patients to physicians (Shiboski et al, 2005;Sink et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Head and Neck Squamous Cell Carcinoma in Iranian Patients and Risk Factors in Young Adults: a Fifteen-Year Study

Mafi

Kadivar²,

Hosseini³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Head and neck squamous cell carcinoma (HNSCC) is the 8th most common cancer worldwide. Although older age, male gender, smoking and alcohol consumption are known risk factors, an increasing number of HNSCC patients are without typical risk factors. Our aim was to define demographics of HNSCC in Iran and the potential risk factors related to Iranian ethnicity and lifestyle. Methods: We conducted a crosssectional analytical study on 262 patients with primary SCC of the larynx, hypopharynx or tongue referred to our pathology department during 1995-2010. Patients' demographics, tumor characteristics and risk factors such as smoking, alcohol consumption and anemia were analyzed and compared in two groups of patients: over 40 years (older group) and 40 years or less (young group); Chi-square and Mann-Whitney analytical tests were employed. Results: 5.7% of patients were young adults. The male to female ratio was 1.5 in the younger group and 5.6 in the older group. In young adults, 40% of tumors were located in larynx and 40% in the tongue. Age >40 was significantly associated with laryngeal location (P<0.001). History of smoking and drinking was significantly associated with age >40 and SCC of larynx in both age groups. Cervical lymph node involvement was significantly correlated with SCC of tongue (P<0.001), however, considering young adults only, SCC of hypopharynx was most frequently accompanied by lymph node involvement (60%). The most prevalent tumor among men was SCC of larynx whereas SCC of hypopharynx was the most prevalent tumor among women (61%), of whom 18.2% were ≤40. Conclusions: The incidence of HNSCC among young adults seems to be higher in Iran compared to other countries. Reduction in exposure to known risk factors, especially tobacco smoking in forms of cigarettes and bubble pipes, and search for other causative agents of HNSCC in young population is recommended.

show abstract

CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Case‐control study on prognostic factors in oral squamous cell carcinoma in young patients

Abstract: This study emphasizes the importance of early diagnosis and aggressive treatment of oral squamous cell carcinoma.

Cited by 33 publications

References 26 publications

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Head and Neck Squamous Cell Carcinoma in Iranian Patients and Risk Factors in Young Adults: a Fifteen-Year Study

CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients

Contact Info

Product

Resources

About