Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population

Yu, Shuyong; Chen, Zhuang; Cheng, Jiajia; Shi, Xingang; Liu, Jiaqi; Zhong, Ping; Song, Jian

doi:10.1186/s12920-022-01367-w

Cited by 3 publications

(2 citation statements)

References 33 publications

(32 reference statements)

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“…Gene mutations are associated with protein expression levels, and gene polymorphisms may play a role in disease susceptibility by affecting gene expression and/or enzyme activity [ 18 , 19 ]. Previous studies have reported that CYP4B1 polymorphisms are significantly correlated with the risk of various cancers, such as gastric cancer [ 20 ], bladder cancer [ 21 ], and lung cancer [ 22 ]. Iscan et al have pointed out that CYP4B1 mRNA is expressed in both breast tumor and tumor-free tissues by reverse transcription-polymerase chain reaction (RT-PCR) [ 23 ].…”

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confidence: 99%

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Yin,

Tong,

Wan

et al. 2023

BMC Cancer

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Background Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene was abnormally expressed in BC and was associated with the prognosis of BC patients. This study aimed to explore the relationship between CYP4B1 single nucleotide polymorphisms (SNPs) and BC risk in Chinese women. Methods A case-control study of 1,143 women (571 patients and 572 healthy individuals) was conducted. Rs2297813 G/T, rs12142787 G/A, and rs3766197 C/T in CYP4B1 were selected and genotyped by MassARRAY system. The relationships between these SNPs and the risk of BC were assessed by logistic regression analysis. In addition, multi-factor dimensionality reduction (MDR) was used to analyze SNP-SNP interactions. Results CYP4B1 rs2297813 had a risk-increasing effect on BC in women with body mass index (BMI) ≤ 24 kg/m2 (OR = 1.72, p = 0.026). CYP4B1 rs12142787 was associated with an increased BC risk in smokers (AA: OR = 1.32, p = 0.045). Among non-drinkers, rs2297813 (OR = 1.69, p = 0.009) and rs12142787 (OR = 1.51, p = 0.020) were related to an increased incidence of BC. CYP4B1 rs3766197 (OR = 1.61p = 0.031) was associated with a higher risk of advanced stages (III/IV stage) of BC. Besides, the contributions of CYP4B1 rs2297813 (OR = 1.55, p = 0.021) and rs12142787 (OR = 1.53, p = 0.033) to BC risk might be associated with more than one birth in patients with BC. The three-locus model consisting of rs2297813, rs12142787, and rs3766197 was regarded as the best predictive model for BC risk. Conclusion CYP4B1 SNPs were associated with BC risk in Chinese women, especially in patients with BMI ≤ 24 kg/m2, smokers, non-drinkers, patients in advanced stages (III/IV stage), and patients who reproduced once. These findings shed light on the relationship between CYP4B1 SNPs and BC risk in Chinese women.

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Section: Introductionmentioning

confidence: 99%

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Yin,

Tong,

Wan

et al. 2023

BMC Cancer

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“…Currently, various factors have been reported that may correlate with the development of GC. In addition to inflammation ( 6 ), infection ( 7 ), environmental, immune, and genetic factors ( 8 ), lifestyle factors may also influence lifetime cancer risk ( 9 ). In observational studies, smoking ( 10 ), alcohol consumption ( 11 ), coffee ( 12 ), and tea intake ( 13 , 14 ) have been identified as factors associated with GC.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study

Tan,

Wei,

Liu

et al. 2023

Front. Oncol.

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BackgroundEpidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal connection between them.MethodsTwo-sample Mendelian randomization (MR) analysis was performed using the publicly available Genome Wide Association Study summary datasets using six methods: inverse variance weighting (IVW), weighted median, MR using a Robust Adjusted Profile Score (MR.Raps), MR using a Robust Adjusted Profile Score (MR-PRESSO), Radial regression of MR, and Causal Analysis Using Summary Effect Estimates (CAUSE). A sensitivity analysis was conducted to assess the robustness of the results.ResultsIn an East Asian population, we found that increased tea intake reduced the risk of GC [odds ratio (OR)= 0.90, 95% confidence interval (CI)= 0.82-0.99, P = 0.037] while there was a positive association between smoking and GC (OR = 1.58, 95% CI = 1.04-2.39, P = 0.032). No causal relationship between alcohol and coffee intake and GC. Sensitivity analyses demonstrated the robustness of these causal associations.ConclusionsOur study suggests that tea intake may reduce the risk of GC, for which smoking is a potential risk factor. Nevertheless, a larger and more diverse sample size is needed for further validation.

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Spotlight on CYP4B1

Röder

Hüsken

Hutter

et al. 2023

IJMS

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The mammalian cytochrome P450 monooxygenase CYP4B1 can bioactivate a wide range of xenobiotics, such as its defining/hallmark substrate 4-ipomeanol leading to tissue-specific toxicities. Similar to other members of the CYP4 family, CYP4B1 has the ability to hydroxylate fatty acids and fatty alcohols. Structural insights into the enigmatic role of CYP4B1 with functions in both, xenobiotic and endobiotic metabolism, as well as its unusual heme-binding characteristics are now possible by the recently solved crystal structures of native rabbit CYP4B1 and the p.E310A variant. Importantly, CYP4B1 does not play a major role in hepatic P450-catalyzed phase I drug metabolism due to its predominant extra-hepatic expression, mainly in the lung. In addition, no catalytic activity of human CYP4B1 has been observed owing to a unique substitution of an evolutionary strongly conserved proline 427 to serine. Nevertheless, association of CYP4B1 expression patterns with various cancers and potential roles in cancer development have been reported for the human enzyme. This review will summarize the current status of CYP4B1 research with a spotlight on its roles in the metabolism of endogenous and exogenous compounds, structural properties, and cancer association, as well as its potential application in suicide gene approaches for targeted cancer therapy.

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Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population

Cited by 3 publications

References 33 publications

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study

Spotlight on CYP4B1

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