Case–control study of oropharyngeal cancer

Vlajinac, Hristina; Marinković, Jelena; Šipetić, Sandra; Andrejic, Dragoslava; Adanja, B; Stošić-Divjak, Svetlana

doi:10.1016/j.cdp.2006.02.001

Cited by 21 publications

(17 citation statements)

References 24 publications

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“…The findings show the age range between 30 to 79 years; this is consistent with some other studies in the western world and Africa (Abiose et al, 1991). Also, males are commoner than females and also consistent with other report (Vlajinac et al, 2006;Alabi et al, 2010;Conway et al, 2007). Table 2 shows squamous cell carcinoma, which is the commonest histologic type; this is consistent with other studies in the industrialized world but varies with a previous study in Jos, Nigeria (same centre as this report) which reported non Hodgkins lymphoma as the commonest histologic type.…”

Section: Discussionsupporting

confidence: 92%

Histopathologic patterns of malignant tumours of the oropharynx of the Jos University Teaching Hospital

Silas¹

2012

J. Clin. Pathol. Forensic Med.

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Malignant tumours of the oropharynx are usually insidious and potentially life threatening. With increased association with risk factors in our environment, its incidence is gradually increasing. This study aim to describe the histopathologic patterns of malignant Oropharygeal tumours as seen in our institution. This is a descriptive retrospective study of all histhologically diagnosed malignant orpharyngeal tumours gotten from the Histopathology Department of the Jos University TeachingHospital (J.U.T.H.), Jos within the period of study (January 2000 to December 2010). 62 oropharyngeal surgical biopsies were analysed out of which 22 were malignant lesions. Out of the 62 oropharygeal surgical biopsies, 22 (35.5%) were malignant; Males were commonest with 72.7% and females 27.3%. Age range was between 30 to 49 years and highest frequency in age range 50 to 59 years. Squamous cell carcinoma accounted for the highest histologic type (63.6%). Followed by non Hogkins lymphomas (22.7%) and adenoid cystic carcinoma (1.6%), respectively. Commonest histologic pattern is the squamous cell carcinoma (well differentiated). It is said to have a good prognosis thus early detection should be encouraged to reduce mobidity and mortality. Avoidance of risk factors should also be emphasized.

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Section: Discussionsupporting

confidence: 92%

Histopathologic patterns of malignant tumours of the oropharynx of the Jos University Teaching Hospital

Silas¹

2012

J. Clin. Pathol. Forensic Med.

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“…These two cancer sites have the strongest and most consistent associations with human papillomavirus (HPV) 16 infection of all the oral cancer sites (12). Although tobacco and alcohol are known to be important risk factors for head and neck malignancies (13, 14), historical trends indicate that these exposures are not diverging between the sexes (15)6,7. This suggests that other risk factors, including oral HPV infection, could be driving the increases in male-to-female IRRs of these sites.…”

Section: Discussionmentioning

confidence: 99%

Sex Disparities in Cancer Incidence by Period and Age

Cook

Dawsey

Freedman

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

358

319

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Background: Cancer epidemiology articles often point out that cancer rates tend to be higher among males than females yet rarely is this theme the subject of investigation. Methods: We used the Surveillance, Epidemiology and End Results program data to compute age-adjusted (2000 U.S. standard population) sex-specific incidence rates and male-to-female incidence rate ratios (IRR) for specific cancer sites and histologies for the period 1975 to 2004. Results: The 10 cancers with the largest male-to-female IRR were Kaposi sarcoma (28.73), lip (7.16), larynx (5.17), mesothelioma (4.88), hypopharynx (4.13), urinary bladder (3.92), esophagus (3.49), tonsil (3.07), oropharynx (3.06), and other urinary organs (2.92). Only 5 cancers had a higher incidence in females compared with males: breast (0.01), peritoneum, omentum, and mesentery (0.18), thyroid (0.39), gall-

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“…With reference to other studies investigating the relation of coffee drinking and HN cancer risk, of the at least eleven case-control studies not included in the INHANCE consortium (8, 9, 13–16, 18, 20, 21, 51), one study from the USA (13), one from Brazil (14) and one from Montenegro (20) considering OP cancer, and six studies considering oral or hypopharyngeal cancer (9, 15, 16, 18, 21, 51) found no significant association with coffee drinking, but the point estimates were below unity in several of them. Each study, however, was not large enough to have adequate statistical power to detect a relatively weak association and often did not focus on coffee or had no adjustment for tobacco smoking and alcohol drinking.…”

Section: Discussionmentioning

confidence: 99%

Coffee and Tea Intake and Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Galeone

Tavani

Pelucchi

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Only a few studies have explored the relation between coffee and tea intake and head and neck cancers, with inconsistent results.Methods: We pooled individual-level data from nine case-control studies of head and neck cancers, including 5,139 cases and 9,028 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for potential confounders.Results: Caffeinated coffee intake was inversely related with the risk of cancer of the oral cavity and pharynx: the ORs were 0.96 (95% CI, 0.94-0.98) for an increment of 1 cup per day and 0.61 (95% CI, 0.47-0.80) in drinkers of >4 cups per day versus nondrinkers. This latter estimate was consistent for different anatomic sites (OR, 0.46; 95% CI, 0.30-0.71 for oral cavity; OR, 0.58; 95% CI, 0.41-0.82 for oropharynx/hypopharynx; and OR, 0.61; 95% CI, 0.37-1.01 for oral cavity/pharynx not otherwise specified) and across strata of selected covariates. No association of caffeinated coffee drinking was found with laryngeal cancer (OR, 0.96; 95% CI, 0.64-1.45 in drinkers of >4 cups per day versus nondrinkers). Data on decaffeinated coffee were too sparse for detailed analysis, but indicated no increased risk. Tea intake was not associated with head and neck cancer risk (OR, 0.99; 95% CI, 0.89-1.11 for drinkers versus nondrinkers).Conclusions: This pooled analysis of case-control studies supports the hypothesis of an inverse association between caffeinated coffee drinking and risk of cancer of the oral cavity and pharynx.Impact: Given widespread use of coffee and the relatively high incidence and low survival of head and neck cancers, the observed inverse association may have appreciable public health relevance. Cancer Epidemiol

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Case–control study of oropharyngeal cancer

Cited by 21 publications

References 24 publications

Histopathologic patterns of malignant tumours of the oropharynx of the Jos University Teaching Hospital

Histopathologic patterns of malignant tumours of the oropharynx of the Jos University Teaching Hospital

Sex Disparities in Cancer Incidence by Period and Age

Coffee and Tea Intake and Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

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