2002
DOI: 10.1192/bjp.180.4.320
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Case–control study of neurocognitive function in euthymic patients with bipolar disorder: An association with mania

Abstract: Impaired verbal learning and memory may be a trait variable in bipolar disease. There are implications for adherence to medication and relapse and for the role of early treatment interventions. Prospective designs and targeting first-episode groups may help to differentiate trait v. disease process effects.

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Cited by 222 publications
(242 citation statements)
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“…A substantial number of studies have now confirmed that many patients with BD have cognitive impairment that persists into the euthymic state. [154][155][156][157][158][159] Impairment has been demonstrated in sustained attention, 160 working memory and executive function, 155 global cognitive functioning, 154 visuospatial recognition memory, 161 problem-solving strategies, 156 declarative memory, 157 and cognitive processing speed. 162 The fact that such impairment is detectable independent of clinical state is suggestive of a trait marker, but factors such as the neuropsychological deterioration secondary to acute episodes of illness, medication treatment, and/or withdrawal effects, long-term effects of comorbid conditions such as substance abuse, or the effect of unrecognized neurobiological changes such as dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis could all contribute to performance deficits in the euthymic state.…”
Section: Cognitive Endophenotypesmentioning
confidence: 99%
“…A substantial number of studies have now confirmed that many patients with BD have cognitive impairment that persists into the euthymic state. [154][155][156][157][158][159] Impairment has been demonstrated in sustained attention, 160 working memory and executive function, 155 global cognitive functioning, 154 visuospatial recognition memory, 161 problem-solving strategies, 156 declarative memory, 157 and cognitive processing speed. 162 The fact that such impairment is detectable independent of clinical state is suggestive of a trait marker, but factors such as the neuropsychological deterioration secondary to acute episodes of illness, medication treatment, and/or withdrawal effects, long-term effects of comorbid conditions such as substance abuse, or the effect of unrecognized neurobiological changes such as dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis could all contribute to performance deficits in the euthymic state.…”
Section: Cognitive Endophenotypesmentioning
confidence: 99%
“…Yazında, hastalık süresi uzadıkça yürütücü işlevler, görsel mekansal bellek ve sözel bellekte bozulmanın arttığı bildirilmiştir. En tutarlı ortak bulgu sözel bellekteki bozulmalarla ilişkilidir (1,11,40,41,(45)(46)(47) .…”
Section: Discussionunclassified
“…Yazında manik dönem sayısı ile bilişsel işlevler arasında negatif ilişki rapor eden çalışmalarda manik dönemlerin tutarlı bir şekilde sözel bellek ve yürütücü işlev testlerinde bozulma ile bağlantılı olduğu gösterilmiştir (11,15,45,46). Bizim çalışmamızda da bu çalışmalarla benzer sonuçlara ulaşılmıştır.…”
Section: Discussionunclassified
“…Some research on bipolar showed negative correlations between number of depressive episodes and executive functions [16,41,42]. Verbal learning was correlated with number of depressive episodes [63] or not [42,52]. Number of manic episodes was connected with worse results in verbal tests and worsening in executive functions tests [16,41,52,54,62,63] and visual memory [88].…”
Section: Factors Associated With Cognitive Deficitsmentioning
confidence: 98%
“…Cognitive impairments result not only from affective disturbances (manic, depression phases) -they are also detectable during the phase free of affective symptoms (remission) Factors associated with cognitive dysfunction in bipolars might be the number of episodes [1,38,54], mainly the number of manic episodes [16,41,52,54,69,70], chronicity [53,54], residual affective symptoms, especially depressive ones [27,38]. Clinical factors associated with cognitive impairment in bipolar patients are medicines such as mood stabilizers, antidepressants and neuroleptics.…”
Section: Factors Associated With Cognitive Deficitsmentioning
confidence: 99%