Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity

Abstract

Experimental procedures, progress of the substrate conversion for heterocyclization reaction (Tables S1 and S2, Figure S18) and monitoring of the reaction mechanism (Figures S19−S22); biological data (Table S4) and assays details, copy of 1 H, 13 C NMR, FT-IR and ESI MS spectra (Figures S23−S88) and spectral assignments, X-ray structural details of 1a−11a (Figures S1−S17; Table S3). (PDF)Accession Codes CCDC 2155685−2155694 and 2245620 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk