Carvacrol/clay hybrids loaded into in situ gelling films

Tenci, Marika; Rossi, Silvia; Aguzzi, Carola; Carazo, E.; Sandri, Giuseppina; Bonferoni, Maria Cristina; Grisoli, Pietro; Viseras, César; Caramella, Carla; Ferrari, Franca

doi:10.1016/j.ijpharm.2017.06.024

Cited by 49 publications

(32 citation statements)

References 43 publications

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“…showed the power of the thyme oil against S. aureus, E. coli, P. aeruginosa and Klebsiella pneumoniae . Carvacrol also has antimicrobial properties inhibiting the growth of S. aureus and E. coli , antifungal and antiviral agents, corroborating with Süntar et al ., who show the effect on the growth of P. aeruginosa and S. aureus .…”

Section: Discussionsupporting

confidence: 84%

“…This phase is characterized by an intense increase in fibroblasts and vascular neoformation . The presence of mature hair follicles, which highlights the remodelling phase, results in the formation of the epithelium and contraction of the wound due to cell proliferation …”

Section: Discussionmentioning

confidence: 99%

“…[73] The presence of mature hair follicles, [12,17] which highlights the remodelling phase, results in the formation of the epithelium and contraction of the wound due to cell proliferation. [74] These isomers also present high antimicrobial potential. Thymol may inhibit the growth of Staphylococcus aureus, Escherichia coli, [20] S. aureus, E. coli and Pseudomonas aeruginosa, [22] S. aureus, Enterococcus faecalis, E. coli and Candida albicans.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

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et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Methods This review was performed at PubMed, SCOPUS, Web of Science databases using keywords as wound healing, thymol/carvacrol and essential oils. Thirteen studies were selected for discussion. Key findings Thymol/carvacrol was able to act in the three phases of wound healing. In the first phase, they showed modulatory effect of the inflammatory cytokines, oxidative stress and antimicrobial power. In the second phase, they promoted re‐epithelialization, angiogenesis and development of granulation tissue. Finally, in the third phase, they improve the collagen deposition and modulated the growth of fibroblasts and keratinocytes. Conclusions These compounds present a high potential for the development of new therapeutic for wound repair. However, dose, efficacy and safety of these compounds for the treatment of wounds, as well as the mechanisms by which those effects can be observed, are challenges for future studies.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2018

Journal of Pharmacy and Pharmacology

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“…In vitro biocompatibility of clay minerals has been widely studied [ 15 , 96 , 97 , 98 , 99 ]. Some clay minerals have already been shown to have proliferating activity in cellular cultures, such as montmorillonite and halloysite [ 100 , 101 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

et al. 2020

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Inorganic hydrogels formulated with spring waters and clay minerals are used to treat musculoskeletal disorders and skin affections. Their underlying mechanism of action for skin disorders is not clear, although it is usually ascribed to the chemical composition of the formulation. The aim of this study was to assess the composition and in vitro release of elements with potential wound healing effects from hydrogels prepared with two nanoclays and natural spring water. In vitro Franz cell studies were used and the element concentration was measured by inductively coupled plasma techniques. Biocompatibility studies were used to evaluate the potential toxicity of the formulation against fibroblasts. The studied hydrogels released elements with known therapeutic interest in wound healing. The released ratios of some elements, such as Mg:Ca or Zn:Ca, played a significant role in the final therapeutic activity of the formulation. In particular, the proliferative activity of fibroblasts was ascribed to the release of Mn and the Zn:Ca ratio. Moreover, the importance of formulative studies is highlighted, since it is the optimal combination of the correct ingredients that makes a formulation effective.

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“…Antibacterial tests highlighted that the gentamicin release could inhibit the bacterial growth of Escherichia coli and Staphylococcus aureus. Up to now different chemically and biologically active molecules with a negative electron density have been successfully loaded on HNTs including insulin [ 76 ], vancomycin [ 77 ], bovine serum albumin [ 78 ], isoniazid [ 78 ], carvacrol [ 79 ], etc. [ 80 , 81 , 82 ].…”

Section: Supramolecular Functionalizationmentioning

confidence: 99%

Past, Present and Future Perspectives on Halloysite Clay Minerals

2020

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Halloysite nanotubes (HNTs), clay minerals belonging to the kaolin groups, are emerging nanomaterials which have attracted the attention of the scientific community due to their interesting features, such as low-cost, availability and biocompatibility. In addition, their large surface area and tubular structure have led to HNTs’ application in different industrial purposes. This review reports a comprehensive overview of the historical background of HNT utilization in the last 20 years. In particular it will focus on the functionalization of the surfaces, both supramolecular and covalent, following applications in several fields, including biomedicine, environmental science and catalysis.

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Carvacrol/clay hybrids loaded into in situ gelling films

Cited by 49 publications

References 43 publications

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

Past, Present and Future Perspectives on Halloysite Clay Minerals

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