Cartilage tissue engineering using resorbable scaffolds

Rotter, Nicole; Bücheler, M.; Haisch, Andreas; Wollenberg, Barbara; Lang, Stephan

doi:10.1002/term.52

Cited by 36 publications

(31 citation statements)

References 44 publications

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“…The literature on the construction of collagenbased 3D-scaffolds in cartilage tissue engineering is vast and cannot possibly be covered in this article (for reviews, see Chajra et al 2008;Rotter et al 2007). Furthermore, growth factors, cytokines, and other bioactive molecules have been included in collagen scaffolds thereby significantly enhancing the differentiation of cells in the repair tissue (Stoddart et al 2009;Tortelli and Cancedda 2009).…”

Section: Biopolymersmentioning

confidence: 98%

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

et al. 2009

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The ultimate goal in the design of biomimetic materials for use in tissue engineering as permanent or resorbable tissue implants is to generate biocompatible scaffolds with appropriate biomechanical and chemical properties to allow the adhesion, ingrowth, and survival of cells. Recent efforts have therefore focused on the construction and modification of biomimetic surfaces targeted to support tissue-specific cell functions including adhesion, growth, differentiation, motility, and the expression of tissue-specific genes. Four decades of extensive research on the structure and biological influence of the extracellular matrix (ECM) on cell behavior and cell fate have shown that three types of information from the ECM are relevant for the design of biomimetic surfaces: (1) physical properties (elasticity, stiffness, resilience of the cellular environment), (2) specific chemical signals from peptide epitopes contained in a wide variety of extracellular matrix molecules, and (3) the nanoscale topography of microenvironmental adhesive sites. Initial physical and chemical approaches aimed at improving the adhesiveness of biomaterial surfaces by sandblasting, particle coating, or etching have been supplemented by attempts to increase the bioactivity of biomaterials by coating them with ECM macromolecules, such as fibronectin, elastin, laminin, and collagens, or their integrin-binding epitopes including RGD, YIGSR, and GFOGER. Recently, the development of new nanotechnologies such as photo- or electron-beam nanolithography, polymer demixing, nano-imprinting, compression molding, or the generation of TiO(2) nanotubes of defined diameters (15-200 nm), has opened up the possibility of constructing biomimetic surfaces with a defined nanopattern, eliciting tissue-specific cellular responses by stimulating integrin clustering. This development has provided new input into the design of novel biomaterials. The new technologies allowing the construction of a geometrically defined microenvironment for cells at the nanoscale should facilitate the investigation of nanotopography-dependent mechanisms of integrin-mediated cell signaling.

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Section: Biopolymersmentioning

confidence: 98%

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

et al. 2009

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“…An important goal in this field is to improve the success rate of tissue engineering strategies by creating more sophisticated materials which can mimic the extra-cellular matrix (ECM), so that the body regenerates "neo-native" functional tissues [2]. One of the major challenges in tissue engineering is articular cartilage regeneration as current regeneration therapies fail producing functional hyaline cartilage and the regenerated tissue has the characteristics of fibrocartilage [3].…”

Section: Introductionmentioning

confidence: 99%

Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(l-lactide) electrospun mats

et al. 2012

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Royal Society of ChemistryAreias, A.; Ribeiro, C.; Sencadas, V.; Garcia Giralt, N.; Diez Perez, A.; Gómez Ribelles, JL.; Lanceros Mendez, S. (2012). Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(L-lactide) electrospun mats. Soft Matter. 8 (21) AbstractPoly(L-lactide) electrospun mates have been produced with random and aligned fiber orientation and degrees of crystallinity from 0 up to nearly 50%. These two factors, fiber alignment and degree of crystallinity strongly affect the hydrophobicity of the samples, being this larger for the aligned fiber mats and for the fibers with higher degree of crystallinity. Whereas the first effect can be associated to a decrease in the degree of porosity the second should be related to variations in the fiber roughness at nanometric scale and an increase in fiber stiffness. Proliferation of human chondrocytes cultured in monolayer on these substrates is similar in both aligned and non-aligned amorphous mats. Crystallization of the aligned mats, on the other hand, nearly suppresses proliferation and the cells produce higher amounts of aggrecan, characteristic of the extracellular matrix of hyaline cartilage.

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“…Nowadays, several modern technologies, such as growth-factor delivery (Lee and Shin 2007 ;Chung and Burdick 2008 ), cartilage tissue engineering (Rotter et al 2007 ;Greene and Watson 2010 ;Ehrlich et al 2010 ), and stem cell therapy, have been proposed and partially applied for regeneration and repair of articular cartilage defects. For these cases, autologous cartilage transplantation is one of the most promising treatment options (see for review Fan et al 2012 ).…”

Section: Marine Cartilage: Tissue Engineeringmentioning

confidence: 99%

Cartilage of Marine Vertebrates

Ehrlich

2014

Biological Materials of Marine Origin

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Cartilage is primarily composed of a specialised extracellular matrix synthesised by chondrocytes and contains of the numerous molecules (collagens, polysaccharides, low molecular peptides). This biological material represents unique avascular tissue. This chapter considers the current state-of-the-art biomaterial characterisation of both non-mineralized and mineralized (calcifi ed) cartilages, with respect to the future tissues in biomimetical and biomedical applications.

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Cartilage tissue engineering using resorbable scaffolds

Cited by 36 publications

References 44 publications

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(l-lactide) electrospun mats

Cartilage of Marine Vertebrates

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