Cartilage stem cells identified, but can they heal?

Chagin, Andrei S.; Medvedeva, Ekaterina V.

doi:10.1038/nrrheum.2017.127

Cited by 18 publications

(15 citation statements)

References 7 publications

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“…In addition to the immune system, chondrocytes and articular MSC populations are major contributors to the healing response. Joint resident MSCs and progenitor cells, contrary to longstanding historical beliefs, are actually relatively abundant in vivo even in adults and occupy several articular niches, including the superficial cartilage zone, synovium and synovial fluid [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. Interestingly, several cell tracing studies showed that MSCs found in experimental cartilage defects in vivo predominantly originate in the synovial membrane rather than in the superficial zone [ 86 , 89 , 92 ].…”

Section: Discussionmentioning

confidence: 99%

“…Joint resident MSCs and progenitor cells, contrary to longstanding historical beliefs, are actually relatively abundant in vivo even in adults and occupy several articular niches, including the superficial cartilage zone, synovium and synovial fluid [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. Interestingly, several cell tracing studies showed that MSCs found in experimental cartilage defects in vivo predominantly originate in the synovial membrane rather than in the superficial zone [ 86 , 89 , 92 ]. MSC senescence and an associated loss of potency could be an important facet of OA pathophysiology [ 93 , 94 , 95 ].…”

Section: Discussionmentioning

confidence: 99%

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Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?

Ribitsch

Bileck

Egerbacher

et al. 2021

IJMS

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Fetal cartilage fully regenerates following injury, while in adult mammals cartilage injury leads to osteoarthritis (OA). Thus, in this study, we compared the in vivo injury response of fetal and adult ovine articular cartilage histologically and proteomically to identify key factors of fetal regeneration. In addition, we compared the secretome of fetal ovine mesenchymal stem cells (MSCs) in vitro with injured fetal cartilage to identify potential MSC-derived therapeutic factors. Cartilage injury caused massive cellular changes in the synovial membrane, with macrophages dominating the fetal, and neutrophils the adult, synovial cellular infiltrate. Correspondingly, proteomics revealed differential regulation of pro- and anti-inflammatory mediators and growth-factors between adult and fetal joints. Neutrophil-related proteins and acute phase proteins were the two major upregulated protein groups in adult compared to fetal cartilage following injury. In contrast, several immunomodulating proteins and growth factors were expressed significantly higher in the fetus than the adult. Comparison of the in vitro MSCs proteome with the in vivo fetal regenerative signature revealed shared upregulation of 17 proteins, suggesting their therapeutic potential. Biomimicry of the fetal paracrine signature to reprogram macrophages and modulate inflammation could be an important future research direction for developing novel therapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?

Ribitsch

Bileck

Egerbacher

et al. 2021

IJMS

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“…The porous PLGA scaffold provides a mechanical carrier and an architectural support. This enables mesenchymal stem cells 29,52,56 and cartilage stem/progenitor cells 7 to migrate into the inner construct and move toward chondrogenesis and osteogenesis differentiation to promote cartilaginous tissue regeneration and subchondral repair, thereby preventing stress at the edges of defects. Furthermore, the PLGA composition can support PRP activation.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and Early Rehabilitation Exercise on Articular Cartilage Repair

et al. 2018

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“…Comparably, Prg4GFPCreERt2 was expressed by superficial chondrocytes in young mice, and expanded into deeper regions with ageing [103]. Similar studies were performed on two other mouse strains and on juvenile animals, observing that the progeny of PRG4+ cells facilitated both appositional and interstitial growth of articular cartilage and could entirely reconstitute adult tissue [104,105,106]. Further research in mouse highlighted that Prg4+ cells are likely to be descendants of growth/differentiation factor 5 positive (GDF5+) cells.…”

Section: Future Perspectivesmentioning

confidence: 94%

Articular Cartilage Regeneration in Osteoarthritis

Roseti

Desando

Cavallo

et al. 2019

Cells

146

103

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There has been considerable advancement over the last few years in the treatment of osteoarthritis, common chronic disease and a major cause of disability in older adults. In this pathology, the entire joint is involved and the regeneration of articular cartilage still remains one of the main challenges, particularly in an actively inflammatory environment. The recent strategies for osteoarthritis treatment are based on the use of different therapeutic solutions such as cell and gene therapies and tissue engineering. In this review, we provide an overview of current regenerative strategies highlighting the pros and cons, challenges and opportunities, and we try to identify areas where future work should be focused in order to advance this field.

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Cartilage stem cells identified, but can they heal?

Cited by 18 publications

References 7 publications

Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?

Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?

Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and Early Rehabilitation Exercise on Articular Cartilage Repair

Articular Cartilage Regeneration in Osteoarthritis

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