Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and Early Rehabilitation Exercise on Articular Cartilage Repair

Chang, Nai-Jen; Erdenekhuyag, Yanjmaa; Chou, Pei-Hsi; Chu, Chih-Jou; Lin, Chih‐Chan; Shie, Ming‐You

doi:10.1177/0363546518780955

Cited by 25 publications

(37 citation statements)

References 57 publications

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“…However, PRP alone (with or without PLGA implants) is limited to osteochondral defect repair without significant regeneration. [8] Preliminary results in survivorship of patients with early stages of osteonecrosis of the femoral head treated with core decompression in association with mesenchymal stem cells implantation, PRP injection, and synthetic bone graft were good. [9] Platelet-rich plasma injection may have a positive role in the treatment of early stages of steroidassociated osteonecrosis of femoral head in a rabbit model.…”

mentioning

confidence: 99%

Every new technique either conservative or surgical is good?

Atik¹

2019

Eklem Hastalik Cerrahisi

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mentioning

confidence: 99%

Every new technique either conservative or surgical is good?

Atik¹

2019

Eklem Hastalik Cerrahisi

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“…[35][36][37][38] PRP is a carrier of multiple cytokines, PDGF, IGF-1, and FGF among them promoting the regeneration of chondrocytes and VEGF, TGF-1 and PDGF-BB promoting angiogenesis. 39,40 Additionally, PRP forms a 3D porous fibrin structure, allowing diffusion of the surrounding components and supporting the differentiation of chondrocytes. 38 By using PRP as a scaffold, Yanaga et al produced clinically applicable cartilage blocks.…”

Section: Discussionmentioning

confidence: 99%

Creating Cartilage in Tissue-Engineered Chamber Using Platelet-Rich Plasma Without Cell Culture

Wang

Chen

et al. 2020

Tissue Engineering Part C: Methods

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Background: Clinically available cartilage, such as large-volume tissue-engineered cartilage, is urgently required for various clinical applications. Tissue engineering chamber (TEC) models are a promising organlevel strategy for efficient enlargement of cells or tissues within the chamber. The conventional TEC technology is not suitable for cartilage culture, because it lacks the necessary chondrogenic growth factor, which is present in platelet-rich plasma (PRP). In this study, we added autogenous auricular cartilage fragments mixed with PRP in a TEC to obtain a large amount of engineered cartilage. Experiment: To prove the efficacy of this method, 48 New Zealand white rabbits were randomly divided into 4 groups: PRP, vascularized (Ves), PRP, PRP+Ves, and control. Auricular cartilage was harvested from the rabbits, cut into fragments (2 mm), and then injected into TECs. Cartilage constructs were harvested at week 8, and construct volumes were measured. Histological morphology, immunochemical staining, and mechanical strength were evaluated. Results: At week 8, PRP+Ves constructs developed a white, cartilage-like appearance. The volume of cartilage increased by 600% the original volume from 0.30 to 1.8-0.1789 mL. Histological staining showed proliferation of edge chondrocytes in the embedded cartilage in the PRP and PRP+Ves groups. Furthermore, the cartilage constructs in the PRP+Ves group show mechanical characteristics similar to those of normal cartilage. Conclusions: Auricular cartilage fragments mixed with PRP and vascularization of the TEC showed a significantly increased cartilage tissue volume after 8 weeks of incubation in rabbits.

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“…However, PRP alone (with or without PLGA implants) is limited to osteochondral defect repair without significant regeneration. [ 4 ]…”

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confidence: 99%