Cartilage regeneration using biodegradable oxidized alginate/hyaluronate hydrogels

Park, Honghyun; Lee, Kuen Yong

doi:10.1002/jbm.a.35126

Cited by 38 publications

(37 citation statements)

References 49 publications

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“…Furthermore, owing to its lack of cell adhesion ability, alginate is usually blended with other polymers. 143,144 An injectable, biodegradable, oxidized alginate/hyaluronic acid hydrogel has been prepared by Park and Lee. 143 At 6 weeks after injection of the hydrogel with primary chondrocytes into mice, effective cartilage regeneration has been observed.…”

Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

“…143,144 An injectable, biodegradable, oxidized alginate/hyaluronic acid hydrogel has been prepared by Park and Lee. 143 At 6 weeks after injection of the hydrogel with primary chondrocytes into mice, effective cartilage regeneration has been observed. In another study, a class of biocompatible and biodegradable alginate-based hydrogel blend has been synthesized by using alginate and O -carboxymethyl chitosan with the addition of fibrin nanoparticles.…”

Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

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Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

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Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

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Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

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“…The physiological environment of articular cartilage is typically avascular and aneural . Moreover, it is well established that the microenvironment of cartilage is hypoxic, with oxygen (O 2 ) tension ranging from <10% at the surface to <1% in the deepest layer …”

Section: Introductionmentioning

confidence: 99%

“…The physiological environment of articular cartilage is typically avascular and aneural. 1 Moreover, it is well established that the microenvironment of cartilage is hypoxic, with oxygen (O 2 ) tension ranging from <10% at the surface to <1% in the deepest layer. 2 However, although cartilage naturally resides in this specific low oxygen tension microenvironment, articular chondrocytes are customarily cultured at normal atmospheric oxygen tension (19-21%).…”

Section: Introductionmentioning

confidence: 99%

Chondroprotective effect of zinc oxide nanoparticles in conjunction with hypoxia on bovine cartilage‐matrix synthesis

Mirza

Chong

Ibrahim

et al. 2015

J Biomedical Materials Res

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Articular cartilage is a tissue specifically adapted to a specific niche with a low oxygen tension (hypoxia), and the presence of such conditions is a key factor in regulating growth and survival of chondrocytes. Zinc deficiency has been linked to cartilage-related disease, and presence of Zinc is known to provide antibacterial benefits, which makes its inclusion attractive in an in vitro system to reduce infection. Inclusion of 1% zinc oxide nanoparticles (ZnONP) in poly octanediol citrate (POC) polymer cultured in hypoxia has not been well determined. In this study we investigated the effects of ZnONP on chondrocyte proliferation and matrix synthesis cultured under normoxia (21% O2 ) and hypoxia (5% O2 ). We report an upregulation of chondrocyte proliferation and sulfated glycosaminoglycan (S-GAG) in hypoxic culture. Results demonstrate a synergistic effect of oxygen concentration and 1% ZnONP in up-regulation of anabolic gene expression (Type II collagen and aggrecan), and a down regulation of catabolic (MMP-13) gene expression. Furthermore, production of transcription factor hypoxia-inducible factor 1A (HIF-1A) in response to hypoxic condition to regulate chondrocyte survival under hypoxia is not affected by the presence of 1% ZnONP. Presence of 1% ZnONP appears to act to preserve homeostasis of cartilage in its hypoxic environment.

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“…A limitation of alginate is that it frequently does not interact with cells and proteins. As stated above, it is necessary for alginate to be combined in a scaffold with another compound that increases its cell attachment capabilities to optimize regeneration of the tissue . Although hydrogels, like alginate, generally promote regeneration, they are not suitable for load‐bearing applications .…”

Section: Materials Used For 3d Bioprintingmentioning

confidence: 99%

Three‐Dimensional Bioprinting Materials with Potential Application in Preprosthetic Surgery

Fahmy

Jazayeri

Razavi

et al. 2016

Journal of Prosthodontics

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Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon's skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom‐designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient‐specific design, but also may be able to prevent micromobility, make tension free soft tissue closure, and improve vascularity. In this manuscript, a review of materials employed in 3D bioprinting including bioceramics, biopolymers, composites, and metals is conducted. A discussion of the relevance of 3D bioprinting using these materials for craniofacial interventions is included as well as their potential to create analogs to craniofacial tissues, their benefits, limitations, and their application.

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Cartilage regeneration using biodegradable oxidized alginate/hyaluronate hydrogels

Cited by 38 publications

References 49 publications

Injectable hydrogels for cartilage and bone tissue engineering

Injectable hydrogels for cartilage and bone tissue engineering

Chondroprotective effect of zinc oxide nanoparticles in conjunction with hypoxia on bovine cartilage‐matrix synthesis

Three‐Dimensional Bioprinting Materials with Potential Application in Preprosthetic Surgery

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