Cartilage-like tribological performance of charged double network hydrogels

Bonyadi, Shabnam Z.; Demott, Connor J.; Grunlan, Melissa A.; Dunn, Alison C.

doi:10.1016/j.jmbbm.2020.104202

Cited by 19 publications

(16 citation statements)

References 57 publications

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“…Bonyadi et al expanded the characterization of these PAMPS/ P(NIPAAm-co-AAm) DN hydrogels by illustrating their articular cartilage-like tribological properties. 132 Tested in a synovial fluid simulant, the DN hydrogels exhibited similar lubrication responses to native articular cartilage specimens, including an elastohydrodynamic regime. Exemplifying the ability to serve as synthetic cartilage replacements, Demott et al developed a resurfacingregenerative bioprosthetic implant incorporating the PAMPS/ P(NIPAAm-co-AAm) DN hydrogel as an articulating surface.…”

Section: Multi-network Hydrogelsmentioning

confidence: 93%

“…While the highlighted DN hydrogel [131][132][133] has shown potential as an articular cartilage replacement, its modulus is below that of other cartilage tissues throughout the body. Thus, Demott et al modified this DN hydrogel through incorporation of a cationic 3rd network of poly((3-acrylamidopropyl)trimethylammonium chloride) (PAPTAC) (PAMPS/P(NIPAAm-co-AAm)/PAPTAC).…”

Section: Multi-network Hydrogelsmentioning

confidence: 99%

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Emerging polymeric material strategies for cartilage repair

Demott

Grunlan

2022

J. Mater. Chem. B

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Section: Multi-network Hydrogelsmentioning

confidence: 93%

Section: Multi-network Hydrogelsmentioning

confidence: 99%

Emerging polymeric material strategies for cartilage repair

Demott

Grunlan

2022

J. Mater. Chem. B

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“…For example, artificial cartilage-like implants should not only avoid FBR but also have excellent lubricity and mechanical strength to meet the requirements of daily activities. Bonyadi et al [ 130 ] prepared four double network hydrogels using poly(2-acrylamido-2- methyl propanesulfonic acid) (PAMPS) as the first network and P(NIPAM (90%)-co-different charged monomers (10%)) as the second network. Results showed that the introduction of only 10% zwitterionic copolymers decreased the surface friction of hydrogel significantly, and the FBS interacted with hydrogel and cartilage in a similar manner.…”

Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

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“…These PNIPAAm-based DN hydrogels also mimicked the tribological properties of articular cartilage. [42] While promising as a substitute for articular cartilage, their moduli did not extend into the higher range of other cartilaginous tissues (e.g., tracheal and temporomandibular joint disc [TMJ], E ≥ 2 MPa; IVD, E ≥ 3 MPa). [4,[43][44][45] Herein, toward achieving ultra-high moduli of numerous cartilage tissues found throughout the body, TN hydrogels leveraging a harmony of both electrostatic repulsive and attractive interactions as well as hydrophobic interactions were prepared (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…These PNIPAAm‐based DN hydrogels also mimicked the tribological properties of articular cartilage. [ 42 ] While promising as a substitute for articular cartilage, their moduli did not extend into the higher range of other cartilaginous tissues (e.g., tracheal and temporomandibular joint disc [TMJ], E ≥ 2 MPa; IVD, E ≥ 3 MPa). [ 4,43–45 ]…”

Section: Introductionmentioning

confidence: 99%

Ultra‐High Modulus Hydrogels Mimicking Cartilage of the Human Body

Demott

Jones

Chesney

et al. 2022

Macromolecular Bioscience

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The human body is comprised of numerous types of cartilage with a range of high moduli, despite their high hydration. Owing to the limitations of cartilage tissue healing and biological grafting procedures, synthetic replacements have emerged but are limited by poorly matched moduli. While conventional hydrogels can achieve similar hydration to cartilage tissues, their moduli are substantially inferior. Herein, triple network (TN) hydrogels are prepared to synergistically leverage intra-network electrostatic repulsive and hydrophobic interactions, as well as inter-network electrostatic attractive interactions. They are comprised of an anionic 1 st network, a neutral 2 nd network (capable of hydrophobic associations), and a cationic 3 rd network. Collectively, these interactions act synergistically as effective, yet dynamic crosslinks. By tuning the concentration of the cationic 3 rd network, these TN hydrogels achieve high moduli of ≈1.5 to ≈3.5 MPa without diminishing cartilage-like water contents (≈80%), strengths, or toughness values. This unprecedented combination of properties poises these TN hydrogels as cartilage substitutes in applications spanning articulating joints, intervertebral discs (IVDs), trachea, and temporomandibular joint disc (TMJ).

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Cartilage-like tribological performance of charged double network hydrogels

Cited by 19 publications

References 57 publications

Emerging polymeric material strategies for cartilage repair

Emerging polymeric material strategies for cartilage repair

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Ultra‐High Modulus Hydrogels Mimicking Cartilage of the Human Body

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