2021
DOI: 10.1016/j.jmbbm.2020.104202
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Cartilage-like tribological performance of charged double network hydrogels

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Cited by 19 publications
(16 citation statements)
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References 57 publications
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“…Bonyadi et al expanded the characterization of these PAMPS/ P(NIPAAm-co-AAm) DN hydrogels by illustrating their articular cartilage-like tribological properties. 132 Tested in a synovial fluid simulant, the DN hydrogels exhibited similar lubrication responses to native articular cartilage specimens, including an elastohydrodynamic regime. Exemplifying the ability to serve as synthetic cartilage replacements, Demott et al developed a resurfacingregenerative bioprosthetic implant incorporating the PAMPS/ P(NIPAAm-co-AAm) DN hydrogel as an articulating surface.…”
Section: Multi-network Hydrogelsmentioning
confidence: 93%
See 1 more Smart Citation
“…Bonyadi et al expanded the characterization of these PAMPS/ P(NIPAAm-co-AAm) DN hydrogels by illustrating their articular cartilage-like tribological properties. 132 Tested in a synovial fluid simulant, the DN hydrogels exhibited similar lubrication responses to native articular cartilage specimens, including an elastohydrodynamic regime. Exemplifying the ability to serve as synthetic cartilage replacements, Demott et al developed a resurfacingregenerative bioprosthetic implant incorporating the PAMPS/ P(NIPAAm-co-AAm) DN hydrogel as an articulating surface.…”
Section: Multi-network Hydrogelsmentioning
confidence: 93%
“…While the highlighted DN hydrogel [131][132][133] has shown potential as an articular cartilage replacement, its modulus is below that of other cartilage tissues throughout the body. Thus, Demott et al modified this DN hydrogel through incorporation of a cationic 3rd network of poly((3-acrylamidopropyl)trimethylammonium chloride) (PAPTAC) (PAMPS/P(NIPAAm-co-AAm)/PAPTAC).…”
Section: Multi-network Hydrogelsmentioning
confidence: 99%
“…For example, artificial cartilage-like implants should not only avoid FBR but also have excellent lubricity and mechanical strength to meet the requirements of daily activities. Bonyadi et al [ 130 ] prepared four double network hydrogels using poly(2-acrylamido-2- methyl propanesulfonic acid) (PAMPS) as the first network and P(NIPAM (90%)-co-different charged monomers (10%)) as the second network. Results showed that the introduction of only 10% zwitterionic copolymers decreased the surface friction of hydrogel significantly, and the FBS interacted with hydrogel and cartilage in a similar manner.…”
Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning
confidence: 99%
“…These PNIPAAm-based DN hydrogels also mimicked the tribological properties of articular cartilage. [42] While promising as a substitute for articular cartilage, their moduli did not extend into the higher range of other cartilaginous tissues (e.g., tracheal and temporomandibular joint disc [TMJ], E ≥ 2 MPa; IVD, E ≥ 3 MPa). [4,[43][44][45] Herein, toward achieving ultra-high moduli of numerous cartilage tissues found throughout the body, TN hydrogels leveraging a harmony of both electrostatic repulsive and attractive interactions as well as hydrophobic interactions were prepared (Figure 1).…”
Section: Introductionmentioning
confidence: 99%
“…These PNIPAAm‐based DN hydrogels also mimicked the tribological properties of articular cartilage. [ 42 ] While promising as a substitute for articular cartilage, their moduli did not extend into the higher range of other cartilaginous tissues (e.g., tracheal and temporomandibular joint disc [TMJ], E ≥ 2 MPa; IVD, E ≥ 3 MPa). [ 4,43–45 ]…”
Section: Introductionmentioning
confidence: 99%